Pattern formation by receptor tyrosine kinases: analysis of the Gurken gradient in Drosophila oogenesis

Cheung, Lily S.; Schüpbach, Trudi; Shvartsman, Stanislav Y.

doi:10.1016/j.gde.2011.07.009

Cited by 30 publications

(21 citation statements)

References 32 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The control of dorsal appendage formation in D. melanogaster eggshells has been extensively studied, with a major focus on patterning by morphogen gradients and the downstream cascades of signaling and transcription (Berg, 2005;Cheung et al, 2011;Wu et al, 2008). Several studies have also examined patterning of the follicular epithelium in other drosophilid species (James and Berg, 2003;Kagesawa et al, 2008;Marmion et al, 2013;Nakamura et al, 2007;Nakamura and Matsuno, 2003;Niepielko et al, 2011Niepielko et al, , 2012Peri et al, 1999;Vreede et al, 2013;Zartman et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

et al. 2015

Self Cite

View full text Add to dashboard Cite

The eggshells of drosophilid species provide a powerful model for studying the origins of morphological diversity. The dorsal appendages, or respiratory filaments, of these eggshells display a remarkable interspecies variation in number and shape, and the epithelial patterning underlying the formation of these structures is an area of active research. To extend the analysis of dorsal appendage formation to include morphogenesis, we developed an improved 3D image reconstruction approach. This approach revealed considerable interspecies variation in the cell shape changes and neighbor exchanges underlying appendage formation. Specifically, although the appendage floor in Drosophila melanogaster is formed through spatially ordered neighbor exchanges, the same structure in Scaptodrosophila pattersoni is formed through extreme changes in cell shape, whereas Drosophila funebris appears to display a combination of both cellular mechanisms. Furthermore, localization patterns of Par3/Bazooka suggest a self-organized, cell polaritybased origin for the variability of appendage number in S. pattersoni. Our results suggest that species deploy different combinations of apically and basally driven mechanisms to convert a two-dimensional primordium into a three-dimensional structure, and provide new directions for exploring the molecular origins of interspecies morphological variation.

show abstract

Section: Introductionmentioning

confidence: 99%

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Drosophila oogenesis is one of the most extensively studied models of EGFR signaling in development. In this case, a gradient of EGFR activation is established by Gurken (GRK), a ligand that is secreted from the oocyte and signals through receptors in the follicular epithelium (5). Acting in concert with other pathways, EGFR controls region-specific expression of multiple genes involved in patterning of the Drosophila eggshell, a complex structure that holds inductive cues necessary for body axes specification during embryogenesis (6).…”

mentioning

confidence: 99%

Transcriptional interpretation of the EGF receptor signaling gradient

Fuchs

Cheung

Charbonnier

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Epidermal growth factor receptor (EGFR) controls a wide range of developmental events, from body axes specification in insects to cardiac development in humans. During Drosophila oogenesis, a gradient of EGFR activation patterns the follicular epithelium. Multiple transcriptional targets of EGFR in this tissue have been identified, but their regulatory elements are essentially unknown. We report the regulatory elements of broad ( br ) and pipe ( pip ), two important targets of EGFR signaling in Drosophila oogenesis. br is expressed in a complex pattern that prefigures the formation of respiratory eggshell appendages. We found that this pattern is generated by dynamic activities of two regulatory elements, which display different responses to Pointed, Capicua, and Mirror, transcription factors involved in the EGFR-mediated gene expression. One of these elements is active in a pattern similar to pip , a gene repressed by EGFR and essential for establishing the dorsoventral polarity of the embryo. We demonstrate that this similarity of expression depends on a common sequence motif that binds Mirror in vitro and is essential for transcriptional repression in vivo.

show abstract

“…miR-318 is uniformly expressed in somatically derived follicle cells during late oogenesis. It has been shown that spatial gene expression patterns in the follicle cells follow a simple combinatorial code based on six basic shapes, including the uniform pattern (Yakoby et al 2008;Cheung et al 2011). The uniform expression pattern of miR-318 in the follicle cells may reflect its function as a uniform repressor.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA

Deng

Guo

et al. 2015

Genetics

View full text Add to dashboard Cite

Pattern formation during epithelial development requires the coordination of multiple signaling pathways. Here, we investigate the functions of an ovary-enriched miRNA, miR-318, in epithelial development during Drosophila oogenesis. mir-318 maternal loss-of-function mutants were female-sterile and laid eggs with abnormal morphology. Removal of mir-318 disrupted the dorsal-anterior follicle cell patterning, resulting in abnormal dorsal appendages. mir-318 mutant females also produced thin and fragile eggshells due to impaired chorion gene amplification. We provide evidence that the ecdysone signaling pathway activates expression of miR-318 and that miR-318 cooperates with Tramtrack69 to control the switch from endocycling to chorion gene amplification during differentiation of the follicular epithelium. The multiple functions of miR-318 in oogenesis illustrate the importance of miRNAs in maintaining cell fate and in promoting the developmental transition in the female follicular epithelium.

show abstract

Pattern formation by receptor tyrosine kinases: analysis of the Gurken gradient in Drosophila oogenesis

Cited by 30 publications

References 32 publications

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

Transcriptional interpretation of the EGF receptor signaling gradient

Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA

Contact Info

Product

Resources

About