Pattern Formation in a Spatially Extended Model of Pacemaker Dynamics in Smooth Muscle Cells

Fatoyinbo, Hammed Olawale; Brown, Richard G.; Simpson, David J. W.; Brunt, Bruce van

doi:10.1007/s11538-022-01043-1

Cited by 3 publications

(1 citation statement)

References 98 publications

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“…One of the striking features exhibited by an ensemble of neurons is the phenomenon of synchronization. Synchronization is a universal concept in dynamical systems that have been studied in fields ranging from biology to physics, to neuroscience, to economics [9][10][11][12][13][14]. Relevant to our study in neurodynamics, a synchronized state can both pertain to a normal or abnormal cognitive state [15].…”

Section: Introductionmentioning

confidence: 99%

On the analysis of a heterogeneous coupled network of memristive Chialvo neurons.

Ghosh

Muni

Fatoyinbo

2023

Preprint

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We perform a numerical study on the application of electromagnetic flux on a heterogeneous network of Chialvo neurons represented by a ring-star topology. Heterogeneities are realized by introducing additive noise modulations on both the central-peripheral and the peripheral-peripheral coupling links in the topology not only varying in space but also in time. The variation in time is understood by two coupling probabilities, one for the central-peripheral connections and the other for the peripheral-peripheral connections respectively, that update the network topology with each iteration in time. We have further reported the rich spatiotemporal patterns like two-cluster states, chimera states, coherent, and asynchronized states that arise throughout the network dynamics. We have also investigated the appearance of a special kind of asynchronization behavior called "solitary nodes" that have a wide range of applications pertaining to real-world nervous systems. In order to characterize the behavior of the nodes under the influence of these heterogeneities, we have studied two different metrics called the "cross-correlation coefficient" and the "synchronization error". Additionally, to capture the statistical property of the network, for example, how complex the system behaves, we have also studied a measure called "sample entropy". Various two-dimensional color-coded plots are presented in the study to exhibit how these metrics/measures behave with the variation of parameters.

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Section: Introductionmentioning

confidence: 99%

On the analysis of a heterogeneous coupled network of memristive Chialvo neurons.

Ghosh

Muni

Fatoyinbo

2023

Preprint

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Pattern Formation in Electrically Coupled Pacemaker Cells

Fatoyinbo

2022

Bull. Aust. Math. Soc.

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Changes in the rat urinary bladder after the relief of outflow obstruction – tracing targets for treatment of persistent symptoms in patients

Andersson

Uvelius²

2022

Front. Urol.

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Studies on patients with bladder outflow obstruction who have undergone surgery for benign prostatic hyperplasia, successfully relieving the obstruction, have revealed a persistence of storage symptoms associated with detrusor overactivity (DO) in 20% to 40% of patients. To study the underlying mechanisms, we have used a common rat model of obstruction/de-obstruction, assuming that non-voiding contractions can be used as a surrogate parameter for DO in humans. Using microarray analysis and electron microscopic images from obstructed and de-obstructed bladder tissue we have tried to identify changes that could serve as a basis for the search of new targets for drugs. Even if voiding function is rapidly normalized after release of outflow obstruction and many of the morphological changes are reversed, the microarray analysis revealed that the de-obstructed rat bladder has gene expressions, structural, and functional properties that make it distinctly different from both control and obstructed bladders. We suggest that whole bladder arrays can be used for identifying cellular mechanisms that could be targets for drugs meant for treatment of persistent DO and LUTS after de-obstruction. Based on available array information for some membrane receptors and morphologic structures with corresponding changes in bladder function, it seems worthwhile to re-assess the development potential for e.g., endothelin receptor antagonists, purinergic receptor antagonists and Rho-kinase inhibitors.

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Pattern Formation in a Spatially Extended Model of Pacemaker Dynamics in Smooth Muscle Cells

Cited by 3 publications

References 98 publications

On the analysis of a heterogeneous coupled network of memristive Chialvo neurons.

On the analysis of a heterogeneous coupled network of memristive Chialvo neurons.

Pattern Formation in Electrically Coupled Pacemaker Cells

Changes in the rat urinary bladder after the relief of outflow obstruction – tracing targets for treatment of persistent symptoms in patients

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