Pattern of acquired heart diseases among children seen in Sokoto, North‑Western Nigeria

Sani, Usman Muhammad; Ahmed, H; Nm, Jiya

doi:10.4103/1119-3077.163284

Cited by 19 publications

(20 citation statements)

References 20 publications

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“…A recent report from Australia similarly documented the highest number of cases of RHD to be in children aged 10–14 years . This is comparable to observations from other studies on children where prevalence of RHD increased with advancing age . Recurrent attacks of ARF and resultant cumulative damage to the heart were contributory factors.…”

Section: Discussionsupporting

confidence: 70%

“…Notably, hospital‐based studies on RHD have reported contrasting prevalence rates of RHD with the northern region of the country having a significantly higher rate . Related studies in recent times have shown no change in the disparity of RHD prevalence across the two regions . Therefore, our estimates may not be generalizable to other parts of the country.…”

Section: Discussionmentioning

confidence: 61%

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Echocardiographic screening of 4107 Nigerian school children for rheumatic heart disease

Ekure

Amadi

Sokunbi

et al. 2019

Tropical Med Int Health

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 61%

Echocardiographic screening of 4107 Nigerian school children for rheumatic heart disease

Ekure

Amadi

Sokunbi

et al. 2019

Tropical Med Int Health

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“…Most of the subjects were female (20 subjects), and a majority of the subjects belong to the >5 years age group. Sani et al found that rheumatic heart disease was the most common heart disease in children >5 years of age (42.7%) [11]. In this study, we found that the most prevalent heart disease was congenital heart disease, which made up for 75% of all cases.…”

Section: Discussionsupporting

confidence: 51%

Correlation between Serum Level of Matrix Metalloproteinase-2 with Left Ventricular End-diastolic Volume in Children with Heart Failure

Mahakrishna¹,

Gunawijaya²,

Artana³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Left ventricular end-diastolic volume (LVEDV) on echocardiography is one of the tests performed on heart failure. This refers to the volume of the left ventricle at the end of the diastolic phase, which would be increased when there is a disturbance in preload, afterload, and contractility factors. Matrix metalloproteinase-2 (MMP2) is a marker of congestive heart failure that can be examined through laboratory examinations. AIM: The objective of the study was to provide evidence of the association between MMP and inflammatory process as well as its correlation with LVEDV in children with heart failure. METHODS: This was a cross-sectional study conducted on children aged 3 months–12 years old with heart failure, who visited Sanglah Hospital, Denpasar, Indonesia from May 2017 to March 2018. Echocardiographic examination (LVEDV) and blood samples were taken to measure the serum level of MMP2 on day 1 after the subjects were diagnosed with heart failure. RESULTS: A total of 32 subjects with heart failure were analyzed in this study. Acyanotic congenital heart defect (CHD) was the most common cause of heart failure, as observed in 23 subjects (71.9%). Characteristics data revealed that 24 subjects (75%) were underweight, 23 (71.9%) had cardiomegaly, and 22 (68.8%) had mild heart failure. Data analysis showed a moderate positive correlation between MMP2 levels with LVEDV after controlling for the influence of age (p = 0.02; r = 0.425). CONCLUSION: There was a moderate positive correlation between MMP2 level and LVEDV after controlling for the age factor.

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“…This has some similarities to an event in Nigeria; an 11-year-old woman who collapsed after her third dose of BPG with symptoms considered anaphylactic by treating doctors. She was resuscitated with epinephrine and other medical therapy 24. We were unable to contact the medical staff involved in this case for inclusion in this case series.…”

Section: Discussionmentioning

confidence: 99%

Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

et al. 2019

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ObjectiveSecondary prophylaxis through long-term antibiotic administration is essential to prevent the progression of acute rheumatic fever to rheumatic heart disease (RHD). Benzathine penicillin G (BPG) has been shown to be the most efficacious antibiotic for this purpose; however, adverse events associated with BPG administration have been anecdotally reported. This study therefore aimed to collate case reports of adverse events associated with BPG administration for RHD prophylaxis.Study designA literature review was used to explore reported adverse reactions to BPG and inform development of a case report questionnaire. This questionnaire was circulated through professional networks to solicit retrospective reports of adverse events from treating physicians. Returned surveys were tabulated and thematically analysed. Reactions were assessed using the Brighton Collaboration case definition to identity potential anaphylaxis.ResultsWe obtained 10 case reports from various locations, with patients ranging in age from early-teens to adults. All patients had clinical or echocardiogram-obtained evidence of valvular disease. The majority of patients (80%) had received BPG prior to the event with no previous adverse reaction. In eight cases, the reaction was fatal; in one case resuscitation was successful and in one case treatment was not required. Only three cases met Level 1 Brighton criteria consistent with anaphylaxis.ConclusionThese results indicate that anaphylaxis is not a major cause of adverse reactions to BPG. An alternative mechanism for sudden death following BPG administration in people with severe RHD is proposed.

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Pattern of acquired heart diseases among children seen in Sokoto, North‑Western Nigeria

Abstract: The pattern of AHD is similar to other studies in developing countries, with RHD being the most prevalent. There is a need for increased emphasis on primary prevention to reduce the burden of these diseases in the study area.

Cited by 19 publications

References 20 publications

Echocardiographic screening of 4107 Nigerian school children for rheumatic heart disease

Echocardiographic screening of 4107 Nigerian school children for rheumatic heart disease

Correlation between Serum Level of Matrix Metalloproteinase-2 with Left Ventricular End-diastolic Volume in Children with Heart Failure

Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

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