Pattern of acute glomerulonephritis in adult population in Dubai: A single-center experience

Alhadari, Amna; Alalawi, Fakhriya; Seddik, Ayman Aly; Zahra, Kaneez; Kumar, Dileep; Yousif, Hussain; Alnour, Hind; Jansen, Michael; Railey, Mohammad

doi:10.4103/1319-2442.206443

Cited by 4 publications

(6 citation statements)

References 2 publications

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“…MPGN and mesangial proliferative GN were each reported in 4.3% of our patients, and these were less prevalent in our cohort compared with that in earlier studies [ 8 – 10 ] owing to an improved infection control; similar results have been reported in recent data from Saudi Arabia [ 22 ] and Dubai [ 21 ].…”

Section: Methodssupporting

confidence: 89%

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Glomerulonephritis Pattern at a Jordanian Tertiary Care Center

Farah

2018

International Journal of Nephrology

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Aim To determine the prevalence and frequency of different pathological patterns of glomerulonephritis (GN) in adolescent (age ≥ 11 years) and adult Jordanian patients. Materials and Methods A retrospective analysis of all clinical and pathological reports of Jordanian patients who had native renal biopsies at the University of Jordan hospital between January 2007 and March 2018 to assess the prevalence and pathological pattern of GN. The data were analyzed statistically using descriptive statistics, the chi-squared test, and Fisher's exact tests. The level of significance was set at P < 0.05. Results Two hundred and nine patients (88 males and 121 females) had native kidney biopsies diagnosed as having GN; the mean age at the time of biopsy was 36.0 ± 14.9 years. Primary GN (51.2%) was more common than secondary GN (48.8%). The most common GN was lupus nephritis (LN) (33.5%), followed by membranous nephropathy (MGN) (15.3%), and diabetic nephropathy (DN) (11.0%). Furthermore, IgA nephropathy was noted in 8.1% of cases. LN was the most common among the secondary GN and occurred in 49.6% of females; MGN was the most common primary GN and occurred in 22.7% of males. There was a statistically significant difference between males and females in the prevalence of LN and MGN (P < .001 and P = .011, respectively). LN was also dominant in all age groups expect for the ≥60 years group, which tended to exhibit DN (40%). Conclusion LN is the most common GN type in Jordan, followed by MGN and DN. MGN is the predominant primary GN with a higher prevalence among males; LN is the predominant secondary GN and tends to occur in Jordanian females. The GN patterns in this study shifted from membranoproliferative GN to MGN in Jordan, which revealed a shift towards similar patterns exhibited in developed countries. Furthermore, DN is the most frequent GN in the elderly.

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Section: Methodssupporting

confidence: 89%

“…As noted in our study, the high-grade proteinuria with or without renal impairment was the clinical indication of kidney biopsy. Among the neighboring countries of Jordan, Qatar has a diabetic nephropathy prevalence of 50% of secondary GN [ 20 ], and Dubai has a diabetic nephropathy prevalence of 14% of secondary GN and 4.4% of GN [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Glomerulonephritis Pattern at a Jordanian Tertiary Care Center

Farah

2018

International Journal of Nephrology

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“…17–19 Interestingly, in one of these studies, LN had the highest incidence among all types of glomerular diseases, even the primary ones. 18…”

Section: The Demographics Of Ln and Ln Morbidity In The Uaementioning

confidence: 99%

“…16 In the UAE, several retrospective studies on the pattern of biopsy-proven renal disease in patients revealed a similar conclusion that LN is the major cause of secondary glomerular disease. [17][18][19] Interestingly, in one of these studies, LN had the highest incidence among all types of glomerular diseases, even the primary ones. 18 End-stage renal disease (ESRD) is the most serious consequence of LN.…”

Section: The Demographics Of Ln and Ln Morbidity In The Uaementioning

confidence: 99%

“…[17][18][19] Interestingly, in one of these studies, LN had the highest incidence among all types of glomerular diseases, even the primary ones. 18 End-stage renal disease (ESRD) is the most serious consequence of LN. Globally, it is estimated that around 5%-20% of SLE patients generally develop ESRD within 10 years of diagnosis, depending on various ethnic, genetic, environmental, and socioeconomic factors.…”

Section: The Demographics Of Ln and Ln Morbidity In The Uaementioning

confidence: 99%

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Lupus nephritis: A focus on the United Arab Emirates and the potential role of genetics

Tabouni

Ali

Aljaberi

et al. 2022

Lupus

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Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), characterized by chronic and progressive inflammation of the kidneys. As with many other autoimmune diseases, LN is a multifactorial disease caused by genetic and environmental factors. Globally, LN can affect around 60% of SLE patients, and it was observed to be less frequent and severe in Caucasian patients compared to other ethnic groups, including Arabs. Data on LN in the United Arab Emirates (UAE) are scattered and scarce in literature. Nevertheless, LN is common, occurring in around 43%–55% of SLE patients in the UAE. Anecdotally, the demographics and clinical features of SLE in the UAE have been distinct. However, the paucity of supporting literature makes it difficult to draw meaningful conclusions. Over the past two decades, there have been improvements in understanding the pathogenesis of LN; however, many cellular and molecular mechanisms which are implicated in the disease development and progression remain ambiguous. Investigating the clinical, pathological, and genetic characteristics of LN in different cohorts of patients is of importance for a better understanding of its pathogenesis, and thus improving its outcome. As a result, we acknowledge the need for large-scale epidemiological, clinical, and genetic investigation of LN cohorts in the UAE and surrounding regions.

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Role of detached podocytes in differentiating between minimal change disease and early focal segmental glomerulosclerosis, can we rely on routine light microscopy?

et al. 2022

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Background Detachment of podocytes represents a turning point in the development of glomerular sclerosis and consequently, of CKD progression. Furthermore, detachment may differentiate minimal change disease (MCD) cases—which have only podocyte effacement—from early focal segmental glomerulosclerosis (FSGS) in which effacement and detachment are observed by electron microscopy. Noteworthy, it is not uncommon for early FSGS to present with clinical presentation and light microscopy (LM) pictures identical to MCD. In our routine practice, we often find cells that lie freely in Bowman’s space by LM. In this study, we try to determine whether these cells are detached podocytes that are worth reporting or just an artifact that can be ignored. Methods To the best of our knowledge, no study has discussed the accuracy of LM in detecting detached podocytes by the routinely used stains. We retrospectively selected 118 cases that were diagnosed as MCD by LM, and searched for detached cells in Bowman’s space in their archived, routinely stained LM slides. After that, we tried to find any correlation between the clinical course, detached cells in LM picture and the EM reports. Results LM can significantly detect detached podocytes with a positive predictive value of 93%, specificity of 85%, and sensitivity of 46%. Significant correlations were found between detached cells and degree of proteinuria and late steroid resistance. Conclusion Detecting detached podocytes by LM is a specific finding that must be reported whenever detected, as it predicts response to steroids and may be able to differentiate MCD from early FSGS by identifying patients who could have podocytopenia.

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Pattern of acute glomerulonephritis in adult population in Dubai: A single-center experience

Cited by 4 publications

References 2 publications

Glomerulonephritis Pattern at a Jordanian Tertiary Care Center

Glomerulonephritis Pattern at a Jordanian Tertiary Care Center

Lupus nephritis: A focus on the United Arab Emirates and the potential role of genetics

Role of detached podocytes in differentiating between minimal change disease and early focal segmental glomerulosclerosis, can we rely on routine light microscopy?

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