Pattern of adverse drug reactions of antitubercular drugs in tuberculosis patients with comorbidities and risk factors in South Indian government health-care facilities

Jayapriya, B; Jafrin, Lourdu; Balamurugan, P.; A, Dinesh Raja

doi:10.5455/njppp.2021.11.07220202105072021

Natl J Physiol Pharm Pharmacol

2021

DOI: 10.5455/njppp.2021.11.07220202105072021

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Pattern of adverse drug reactions of antitubercular drugs in tuberculosis patients with comorbidities and risk factors in South Indian government health-care facilities

B Jayapriya¹,

Lourdu Jafrin²,

P. Balamurugan³

et al.

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Adverse Drug Events from First-Line Anti-tuberculosis Drugs in a Tertiary Medical Center

Jorge,

Esporlas,

Largoza

et al. 2024

EMJ

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Background: Tuberculosis (TB) has remained one of the top causes of morbidity and mortality in the Philippines since 2018. However, adverse drug reactions (ADR) from first-line anti-tuberculosis medications such as rifampicin, isoniazid, pyrazinamide, and ethambutol cause significant impact on treatment adherence. This study aimed to determine the incidence of ADRs among patients treated with first-line anti-tuberculosis medications at a Philippine Department of Health tertiary medical centre. Methods: In this retrospective cohort study, rifampicin-susceptible patients undergoing first-line anti-TB treatment enrolled in the Tuberculosis-Directly Observed Treatment Strategy at the East Avenue Medical Centre, Quezon City, Philippines, were included.Pertinent data obtained from chart review included sociodemographic factors, clinical characteristics, duration of treatment prior to the appearance of adverse drug reactions, type of ADRs, TB medication causing the ADR, and treatment outcomes. Results: A total of 524 patients treated with first-line anti-TB treatment were identified, with 46 (8.78%) noted to have ADRs to the treatment regimen. Most reaction types included mild or localised skin reactions (34.8%), severe skin rash secondary to hypersensitivity (32.6%), and jaundice due to hepatitis (21.7%). Reaction to more than one medication was seen in 89.1% of patients with ADRs, with rifampicin having the highest frequency of ADR (4.3%) among the anti-TB medications. Conclusion: The incidence of ADRs among patients treated with first-line anti-TB medications at East Avenue Medical Centre in the Tuberculosis-Directly Observed Treatment Strategy is frequent and comparable to other relevant study populations. A larger sample size and exploration of other methodological studies are recommended to further expand on this study.

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Adverse Drug Events from First-Line Anti-tuberculosis Drugs in a Tertiary Medical Center

Jorge,

Esporlas,

Largoza

et al. 2024

EMJ

View full text Add to dashboard Cite

show abstract

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Pattern of adverse drug reactions of antitubercular drugs in tuberculosis patients with comorbidities and risk factors in South Indian government health-care facilities

Cited by 1 publication

References 0 publications

Adverse Drug Events from First-Line Anti-tuberculosis Drugs in a Tertiary Medical Center

Adverse Drug Events from First-Line Anti-tuberculosis Drugs in a Tertiary Medical Center

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