Pattern of Blood Stream Infections and their antibiotic susceptibility profile in a Neonatal intensive care unit of a tertiary care hospital;
a Current perspective .

Sana, Fatima; Satti, Luqman; Zaman, Gohar; Gardezi, Adeel; Imtiaz, Anam; Khadim, Tahir

doi:10.5455/jpma.298528

Cited by 8 publications

(12 citation statements)

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“…Klebsiella, the second commonest pathogen isolated in the current study showed sensitivity to Ciprofloxacin, Levofloxacin, and Meropenem while resistance to Cefixime and Aztreonam followed by Amoxicillin and Ceftriaxone was observed. The efficacy of Meropenem for Klebsiella was also proved in another study in Rawalpindi 15 . Cultures with the growth of grampositive organisms including Staph aureus and Coagulase-negative Staphylococcus showed the best sensitivity to Teicoplanin, Linezolid, and Vancomycin.…”

Section: Discussionmentioning

confidence: 75%

Neonatal sepsis and resistance pattern of isolates in Tertiary level neonatal unit: Time to evaluate the empirical antibiotics selection

Ehtizaz¹,

Haider²,

Fayyaz³

et al. 2021

JRMC

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Objective: To find out the most common organisms involved in neonatal sepsis origination and observe the pattern of antibiotic sensitivity and resistance of bacterial isolates. Materials and Methods: This descriptive cross-sectional study was conducted at the Department of Paediatrics Izzat Ali Shah Hospital, Wah Cantt. Out of 420 patients admitted with sepsis in NICU, 19.5% of patients with positive blood cultures were included in the study. A consecutive, non-probability sampling technique was used. Results: Out of 82 positive blood cultures gram-positive bacteria were observed in 19 patients (23.2%) and gram-negative bacteria were seen in 63 patients (76.8%). The most common gram-negative pathogens isolated were Acinetobacter (29.3%) and Klebsiella (24.4%). Staphylococcus aureus (12.2%) was the commonest gram-positive organism isolated. Gram-negative organisms showed maximum sensitivity to Tigecycline and Colistin and were resistant to Cefixime, Aztreonam, Amoxicillin, and Ceftriaxone. Gram-positive bacteria were sensitive to Teicoplanin, Linezolid, and Vancomycin while resistance was shown to penicillin and amoxicillin.Conclusion: The current study showed that gram-negative bacteria were the major contributors to sepsis in the respective setup and showed resistance to first-line antibiotics such as Penicillins and Cephalosporins. Strict infection control measures need to be implemented to avoid the emergence of resistant strains of pathogens in NICUs. This will help to reduce the incidence of neonatal sepsis leading to mortality.

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Section: Discussionmentioning

confidence: 75%

Neonatal sepsis and resistance pattern of isolates in Tertiary level neonatal unit: Time to evaluate the empirical antibiotics selection

Ehtizaz¹,

Haider²,

Fayyaz³

et al. 2021

JRMC

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“…The positivity rate was 36% which is comparable to a study conducted at the Armed Forces Institute of Pathology, Rawalpindi (27%),. 17 Another study in Pakistan reported BSIs as the second most…”

Section: Discussionmentioning

confidence: 99%

“…This is higher than that reported in various regional studies. 22,23 The management of VRE infections poses a real challenge for the clinicians, as the therapeutic option is often limited to linezolid.…”

Section: P R O V I S I O N a L L Y A C C E P T E D F O R P U B L I C ...mentioning

confidence: 99%

Distribution of the invasive pathogenic isolates in blood culture with their antimicrobial susceptibility pattern in diagnostic lab in Karachi

Fatima

Gohar²,

Dawood³

et al. 2022

J Pak Med Assoc

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Objective: To determine the frequent bacterial pathogens causing blood stream infections in various age brackets, and to discover their antibiotic susceptibility pattern. Method: The retrospective, descriptive, observational, cross-sectional study was conducted at the microbiology laboratory of Patel Hospital, Karachi, and comprised positive blood culture bacterial isolates analysed between July 1, 2018, and June 30, 2019. Standard microbiological techniques were employed for the identification and antimicrobial susceptibility testing. Data was analysed using SPSS 20. Results: Of the 3450 specimen, 1243(36%) were positive; 668(53.7%) from male and 575(46.3%) from female subjects, and gram-positive 771(62%) and gram-negative 472(38%). Salmonella typhi was the most common pathogen 139(11.1) among gram-negative organisms, followed by acinetobacter species 103(8.2%), escherichia coli 96(7.7%) and klebsiella species 42(3.4%). Among gram-positive bacteria, the predominant isolates were staphylococcus epidermidis 650(52%), staphylococcus aureus 67(5.4%) and enterococci 28(2.3%). Linezolid (99.8%), vancomycin (99%) and chloramphenicol (69%) were found to be the most sensitive antibiotics among gram-positive cocci. Meropenem (60%), amikacin (46%) and gentamicin (40%) were the most sensitive antibiotics for multidrug resistant gram-negative bacteria. Conclusion: The identification of frequent bacterial pathogens in blood cultures of patients may guide clinicians in proper empirical selection of antibiotics in patients with bacteremia. Key Words: Blood stream infection, BSI, Antibiotic susceptibility, AST, Bacteriological profile, Multi-drug resistance, MDR.

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“…Early detection of bloodstream infections with prompt antimicrobial therapy could prevent implantation of microorganisms into vital organs such as brain, lungs, heart or kidneys and eventually improved clinical outcome. Additionally, empirical therapy guided by local susceptibility profile is also crucial for successful management of patients with BSIs [3,11]. There's a strong relationship between delay in initiation of effective therapy and mortality from blood stream infections.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility Pattern of Pathogens Causing Blood Stream Infections in a Tertiary Care Hospital: A Two-year Retrospective Study from Southern Nigeria

Ekeng

Emanghe

Monjol

et al. 2021

MRJI

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Aim: Bloodstream infections are a major cause of morbidity and mortality worldwide. The prevalence of causative microorganisms varies from one geographical region to another. This study was aimed at determining the etiological agents prevalent in our environment and their susceptibility profile. Study design: This is a retrospective study carried out at the University of Calabar Teaching Hospital, Calabar, Nigeria. Methodology: Blood culture results of patients documented over a two-year period were retrieved and analyzed. Blood culture positive isolates were detected using conventional method and Oxoid signal blood culture systems. Antimicrobial sensitivity tests were carried out by Kirby-Bauer disc diffusion method. Methicillin resistance in Staphylococcus aureus and coagulase negative Staphylococcus species (CoNS) was detected by disk diffusion method using 30 µg cefoxitin disk. ESBL production was detected by phenotypic confirmatory disc diffusion test (PCDDT) and the double disc synergy test (DDST). Results: A total of 413 blood culture antimicrobial susceptibility test results were analyzed, of which 116 (28.09%) were identified as culture positive. Sixty-nine (59%) of the positive isolates were from female patients. Out of 116 positive cultures, 58.62% (68/116) were Gram positive organisms, 40.52% (47/116) were Gram negative organisms, non albicans Candida accounted for 0.86% (1/116). Staphylococcus aureus (n=41, 35.3%) was the predominant isolate and showed high sensitivity to levofloxacin (100%), Linezolid (100%) and Amikacin (100%). Twelve isolates of S. aureus were methicillin resistant, while 1 isolate was inducible clindamycin resistant. Of the 116 isolates identified in this study, forty-three (43) were multidrug resistant with highest number of multidrug resistant isolates from Staphylococcus aureus (n=20). 21.28% (n=10) of the Gram-negative isolates were positive for extended spectrum beta lactamases. Conclusion: A high rate of antimicrobial resistance is observed among microorganisms causing blood stream infections. This emphasizes the need for antimicrobial sensitivity testing in the management of blood stream infections.

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Pattern of Blood Stream Infections and their antibiotic susceptibility profile in a Neonatal intensive care unit of a tertiary care hospital; a Current perspective .

Cited by 8 publications

References 0 publications

Neonatal sepsis and resistance pattern of isolates in Tertiary level neonatal unit: Time to evaluate the empirical antibiotics selection

Neonatal sepsis and resistance pattern of isolates in Tertiary level neonatal unit: Time to evaluate the empirical antibiotics selection

Distribution of the invasive pathogenic isolates in blood culture with their antimicrobial susceptibility pattern in diagnostic lab in Karachi

Susceptibility Pattern of Pathogens Causing Blood Stream Infections in a Tertiary Care Hospital: A Two-year Retrospective Study from Southern Nigeria

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