Pattern of congenital heart diseases in Rwandan children with genetic defects

Teteli, Raissa; Uwineza, Annette; Butera, Yvan; Hitayezu, Janvier; Murorunkwere, Seraphine; Umurerwa, L.; Ndinkabandi, Janvier; Hellin, Anne-Cécile; Jamar, Mauricette; Caberg, Jean‐Hubert; Muganga, Narcisse; Mucumbitsi, Joseph; Rusingiza, Emmanuel; Mutesa, Léon

doi:10.11604/pamj.2014.19.85.3428

Cited by 10 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the most common types detected of cyanotic congenital heart defects were tetralogy of Fallot 38.9%, complete AV canal 22.1%, 18.2% compared to many unfrequented types as double inlet left ventricle and truncus arteriosis (1.3%). These results are in accordance with studies in Gorgan, northern Iran [17], South distract in Iran [20] Rwanda [4], and Xinjiang in China [21]. The study was done in India presented ASD was the commonest lesion followed by VSD similar to our study [18].…”

Section: Discussionsupporting

confidence: 92%

“…In infancy and childhood, the diseases are considered the second leading cause of death [1][2][3]. Congenital heart diseases are the most prevalent types of birth defects [4] with the incidence of 10 per 1000 live births [5]. However, different studies reported variable incidence rates from about 4/1000 to 50/1000 live births [6].…”

Section: Introductionmentioning

confidence: 99%

“…The cyanotic congenital heart disease (CCHD) is an important and severe type of complex cardiac anomalies obvious to the clinician with hypoxia resulting in clinical cyanosis [7]. Cyanotic congenital heart diseases include tetralogy of Fallot (TOF), truncus arteriosus (TAr), transposition of the great arteries (TGA), tricuspid atresia (TAr), and double-outlet right ventricle (DORV) the situation in which both great arteries (pulmonary artery and aorta) [4,7,8]. The non-cyanotic CHD can further be subclassified into obstructive and non-obstructive acyanotic congenital heart disease.…”

Section: Introductionmentioning

confidence: 99%

“…While the right side noncyanotic obstructions include congenital tricuspid stenosis, pulmonary artery stenosis (PS), valvar pulmonary artery stenosis [7,8]. The non-obstructive non-cyanotic heart defect includes ventricular septal defect (VSD) which is the second most common types of heart malformations, atrioventricular septal defect (AVSD), patent ductus arteriosus and atrial septal defect [4,7,9] [10]. There have been no studies on the incidence of these defects in Sulaimani; therefore the current study was undertaken to estimate incidence and types of CHD in the governorate.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence and Types of Congenital Heart Diseases among Children in Sulaimani Governorate

Kamal

Othman

Salih

2017

KJAR

View full text Add to dashboard Cite

Congenital heart diseases (CHD) are common causes of cardiovascular morbidity and mortality among young children and adolescents. It is the most common form of structural congenital defects. Little is known about incidence and type of these disorders in Sulaimani. Therefore, this study was undertaken to determine the incidence of congenital heart diseases and their types in Sulaimani Governorate. The study was conducted in Sulaimani Pediatric Teaching Hospital and the Maternity Hospital during January 2015 to December 2016. A sample of 400 consecutive cases of CHD in children aged 0-12 years was recruited attending the echocardiographic department of the hospital for diagnosis or follow-up purposes. Demographic data was collected through a face-to-face interview with the mothers of cases. A total number of new live births for 2015-2016 and those with congenital heart diseases were obtained from the medical records of the department of statistics of Sulaimani Maternity Teaching Hospital. The overall incidence of all types of congenital heart diseases was 1.7/1000, 1.6/1000 live births for the year 2015 and 2016 respectively. There was a statistically significant difference in incidence between males and females over the two years, male to female risk ratio 1.83 (95% CI 1.09-3.14, p 0.007). The commonest types of cyanotic congenital heart diseases were tetralogy of Fallot (38.9% of all cyanotic defects), complete atrioventricular canal (22.1%), and transposition of great arteries (18.2%), while the most common types of non-cyanotic congenital heart disease were atrial septal defect (34.1% of all non-cyanotic defects), ventricular septal defect (31.6%), and the other defects are less common. In conclusion, tetralogy of Fallot, atrial septal defects, and ventricular septal defects are the commonest congenital heart deformities in Sulaimani Governorate; the incidence is lower than other countries but this could be an underestimation.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidence and Types of Congenital Heart Diseases among Children in Sulaimani Governorate

Kamal

Othman

Salih

2017

KJAR

View full text Add to dashboard Cite

show abstract

“…Ventricular septal defect and patent ductus arteriosus were the commonest congenital heart defects in our series (Teteli et al. 2014). …”

Section: Genetic Services In Rwandamentioning

confidence: 99%

Medical genetics and genomic medicine in Rwanda

Uwineza

Mutesa

2015

Molec Gen & Gen Med

Self Cite

View full text Add to dashboard Cite

show abstract

Identification of epigenetic factor KAT2B gene variants for possible roles in congenital heart diseases

et al. 2020

View full text Add to dashboard Cite

Congenital heart disease (CHD) is a group of anatomic malformations in the heart with high morbidity and mortality. The mammalian heart is a complex organ, the formation and development of which are strictly regulated and controlled by gene regulatory networks of many signaling pathways such as TGF-β. KAT2B is an important histone acetyltransferase epigenetic factor in the TGF-β signaling pathway, and alteration in the gene is associated with the etiology of cardiovascular diseases. The aim of this work was to validate whether KAT2B variations might be associated with CHD. We sequenced the KAT2B gene for 400 Chinese Han CHD patients and evaluated SNPs rs3021408 and rs17006625. The statistical analyses and Hardy–Weinberg equilibrium tests of the CHD and control populations were conducted by the software SPSS (version 19.0) and PLINK. The experiment-wide significance threshold matrix of LD correlation for the markers and haplotype diagram of LD structure were calculated using the online software SNPSpD and Haploview software. We analyzed the heterozygous variants within the CDS region of the KAT2B genes and found that rs3021408 and rs17006625 were associated with the risk of CHD.

show abstract

Pattern of congenital heart diseases in Rwandan children with genetic defects

Cited by 10 publications

References 23 publications

Incidence and Types of Congenital Heart Diseases among Children in Sulaimani Governorate

Incidence and Types of Congenital Heart Diseases among Children in Sulaimani Governorate

Medical genetics and genomic medicine in Rwanda

Identification of epigenetic factor KAT2B gene variants for possible roles in congenital heart diseases

Contact Info

Product

Resources

About