Pattern of contact sensitization in patients with and without atopic dermatitis in an Asian dermatology center

Wee, Charlene Li Ping; Tan, Chee Hian; Zhao, Xiahong; Yew, Yik Weng; Goon, Anthony Teik‐Jin

doi:10.1111/cod.14068

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Most patients (80%) showed polysensitization to two or more steroid allergens, with the highest PPTRs for 0.1% budesonide and 0.1% betamethasone-17-valerate 33 . However, the most recent study by Wee et al 34 found that patients with AD were less likely to develop contact sensitization to budesonide. It is possible that the aforementioned result is attributable to the criteria of the AD group, which was established by the diagnostic code of AD-related diseases.…”

Section: Discussionmentioning

confidence: 97%

Analysis of Positive Patch Test Allergens in Allergic Contact Dermatitis Patients with Atopic Dermatitis

et al. 2023

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Background There has been debate regarding whether patients with atopic dermatitis (AD) have an altered frequency of contact allergen sensitization. Increased exposure to topical medications and moisturizers as well as impaired skin barrier function increase the risk of contact sensitization, whereas the Th2-skewed inflammatory pathway of AD is associated with a reduced risk. Objective This retrospective study was performed to determine the characteristics of contact sensitization in allergic contact dermatitis (ACD) patients with a current or past history of AD. Methods A clinical record review was conducted for patients referred to Ewha Womans University Medical Center, for patch tests between March 2017 and March 2021. We compared the rates of contact sensitization between ACD patients with and without AD. Results In total, 515 patch test results were reviewed and divided into the AD group (n=53) and non-AD group (n=462). The AD group showed decreased any-allergen positivity (1+, 2+, or 3+) (56.6%) compared to the non-AD group (72.9%) ( p =0.013). The positivity rate for budesonide was significantly higher in the AD group ( p =0.011), while the prevalence of a positive result for balsam of Peru was higher in the non-AD group ( p =0.036). Nickel sulfate, cobalt chloride, and potassium dichromate were the most common sensitized allergens in both groups. Conclusion Our study shows a decreased prevalence of contact sensitization in AD patients compared to non-AD patients. Clinicians should be aware of the risk of corticosteroid allergies in ACD patients with history of AD.

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Section: Discussionmentioning

confidence: 97%

Analysis of Positive Patch Test Allergens in Allergic Contact Dermatitis Patients with Atopic Dermatitis

et al. 2023

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Tolerogenic phenotype of dendritic cells is induced after hapten sensitization followed by attenuated contact hypersensitivity response in atopic dermatitis model NC/Nga mice

Nakayama,

Tetsu,

Nishijo

et al. 2023

Biochemical and Biophysical Research Communications

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The sesquiterpene lactone mix: A review of past, present and future aspects

Paulsen

2023

Contact Dermatitis

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The sesquiterpene lactones (SLs) are secondary plant metabolites, which are widespread in the Compositae/Asteraceae plant family. The first SLs were detected more than 100 years ago, and allergic contact dermatitis from Compositae has been reported since the beginning of the 1900s, but it was not until the late 1960s and early 1970s that a collaboration between dermatologists, chemists and botanists led to the detection of SLs as the main allergens of Compositae plants. In the 1980s, the SL mix, consisting of equimolar amounts of alantolactone, costunolide and dehydrocostus lactone, was developed as a screening agent for Compositae sensitisation. Today, after inclusion of SL mix in the baseline series, the mean prevalence of reactions in Europe is around 1%, and in North America 0.8%. In countries outside Europe and North America, the prevalence ranges between 0% and 10.7%. The detection rate of SL mix is lower than that of some plant extracts, and ideally, SL mix should be supplemented with a mix of SLs from locally prevalent allergenic plants. The prevalence of positive reactions to SL mix suggests continued baseline testing in most European countries, North America, New Zealand, Australia and probably some Chinese centres.

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Pattern of contact sensitization in patients with and without atopic dermatitis in an Asian dermatology center

Cited by 5 publications

References 33 publications

Analysis of Positive Patch Test Allergens in Allergic Contact Dermatitis Patients with Atopic Dermatitis

Analysis of Positive Patch Test Allergens in Allergic Contact Dermatitis Patients with Atopic Dermatitis

Tolerogenic phenotype of dendritic cells is induced after hapten sensitization followed by attenuated contact hypersensitivity response in atopic dermatitis model NC/Nga mice

The sesquiterpene lactone mix: A review of past, present and future aspects

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