Pattern of Cytokine Production by T Cells from Adolescents with Asthma in Remission, after Stimulation with Dermatophagoides farinae Antigen

Noma, Takeshi; Yoshizawa, Izumi; K, Kou; Nakajima, Tadashi; Y, Kawano; Itoh, Masahiko; Ichikawa, Kunio; Mukouyama, Tokuko; Baba, Minoru; Yata, Junichi

doi:10.1203/00006450-199508000-00009

Cited by 19 publications

(27 citation statements)

References 23 publications

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“…Our findings are consistent with other workers who have described increased IFN‐γ production in response to allergens in childhood [11–14, 19] and adult atopics [20, 21], although none have demonstrated the increased IFN‐γ response to allergens and decreased response to a polyclonal stimulus simultaneously. The findings of increased IFN‐γ to allergen but decreased IFN‐γ to a polyclonal stimulus are not necessarily inconsistent.…”

Section: Discussionsupporting

confidence: 93%

Increased Th1 and Th2 allergen‐induced cytokine responses in children with atopic disease

Smart

Kemp

2002

Clin Experimental Allergy

127

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We show that a polyclonal stimulus induces a reduced Th1 (IFN-gamma) and increased Th2 (IL-4 and IL-5) cytokine pattern. In contrast, the allergen-induced cytokine responses in atopic children were associated with both increased Th1 (INF-gamma) and Th2 (IL-5 and IL-13) cytokine production. The increased Th1 response to allergen is likely to reflect prior sensitization and indicates that increases in both Th1 and Th2 cytokine production to allergens exists concomitantly with a decreased Th1 response to a polyclonal stimulus in atopic children.

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Section: Discussionsupporting

confidence: 93%

Increased Th1 and Th2 allergen‐induced cytokine responses in children with atopic disease

Smart

Kemp

2002

Clin Experimental Allergy

127

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“…This finding suggests that the reduced IFN-c production that has been observed at birth prior to the onset of atopic disease may not be permanent. This is also consistent with the observations of a number of studies that IFN-c production in response to polyclonal stimuli is reduced in childhood AD (7,9,18,28) and asthma (29-31), but is not reduced in adult (32) or adolescent asthmatics (33). Such observations raise the possibility that maturation of the Th1/IFN-c response may be a factor in the observed changes in atopic disease throughout childhood, with resolution of symptoms, such as AD and food allergy, being a common finding.…”

Section: Discussionsupporting

confidence: 92%

Ontogeny of T‐helper 1 and T‐helper 2 cytokine production in childhood

Smart

Kemp

2001

Pediatric Allergy Immunology

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Compared to adults, infants and young children demonstrate differences in their immune response, indicating that there is maturation or change over time and it is probable that this may be reflected in cytokine production. Cytokine responses have been demonstrated to be different in atopic and non-atopic individuals. In this study, we examined T-helper 1 (Th1) (interferon-gamma [IFN-gamma]) and T-helper 2 (Th2) (interleukin [IL]-4, IL-5, and IL-13) cytokine release from atopic and non-atopic children in response to the staphylococcal superantigen, staphylococcal enterotoxin B (SEB). In non-atopic and atopic children, IFN-gamma, IL-4, and IL-5 release was significantly related to age. Non-atopic children younger than 2 years of age were found to have significantly reduced Th2 (IL-4, IL-5, and IL-13) responses when compared with older, non-atopic children. Atopic children had a reduced IFN-gamma response when compared with non-atopics in early childhood; however, the decreased IFN-gamma response seen in early childhood did not persist after 10 years. These age-related changes in cytokine production provide further support for the concept that cytokine deviations may determine the natural history of atopic disease during early childhood. In addition, the present study indicates the necessity of age-matched controls when examining children for both Th1 (IFN-gamma) and Th2 (IL-4) cytokine release.

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“…T. Noma et al As previously reported, Df-induced IL-4 production by PBMCs is up-regulated in patients with Df-sensitive bronchial asthma whereas IFN-g production is down-regulated [16]. The cytokine imbalance was restored, and IFN-g production increased markedly in patients in remission [16].…”

mentioning

confidence: 78%

“…Asthma improves in most children during adolescence such that a small minority of patients exhibit clinically significant symptoms by the age of 20 years [ 13–15]. Up‐regulated interferon (IFN)‐γ production in children with asthma after exposure to Df antigen might reduce IL‐4 secretion by Df‐stimulated cells and result in suppression of IgE production and clinical improvement [ 16]. To further investigate late allergic reactions, including eosinophil inflammation, associated with outgrowing mite antigen‐induced bronchial asthma during adolescence, we studied the relationship between clinical status and relevant antigen‐induced functional, but not antigenic, activity of IL‐5 produced in culture by Df‐stimulated PBMCs from patients with atopy, assessed with mouse IL‐3‐dependent cells, FDC‐P1, transfected with the human IL‐5 receptor gene (FDC‐h5R) [ 17].…”

Section: Introductionmentioning

confidence: 99%

Functional interleukin‐5 activity in peripheral blood mononuclear cells from adolescents with mite antigen asthma in remission

Noma

Hayashi

Kawano

et al. 1999

Clin Experimental Allergy

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Pattern of Cytokine Production by T Cells from Adolescents with Asthma in Remission, after Stimulation with Dermatophagoides farinae Antigen

Cited by 19 publications

References 23 publications

Increased Th1 and Th2 allergen‐induced cytokine responses in children with atopic disease

Increased Th1 and Th2 allergen‐induced cytokine responses in children with atopic disease

Ontogeny of T‐helper 1 and T‐helper 2 cytokine production in childhood

Functional interleukin‐5 activity in peripheral blood mononuclear cells from adolescents with mite antigen asthma in remission

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