Pattern of expression of c-Myc, Max and Bin1 in human anagen hair follicles

Abstract

The results indicate that the asynchronous differentiation along the axis of the hair follicle of the different layers of the IRS and of the companion layer involves the expression of different genes that are interrelated in the so-called 'Myc network'. The specific localization of c-Myc in the IRS only at the level of the discrete and limited regions of the three rings appears to be the hallmark of the switch from differentiation to terminal differentiation/cell deletion.

Immunohistochemical expression of β‐catenin, E‐cadherin, cyclin D1 and c‐myc in benign trichogenic tumors

“…Both cyclin D1 and c‐myc are important cell cycle regulators and have been shown to play important roles in the control of cell growth, differentiation, apoptosis and neoplastic transformation 24–28 . Owing to their multifactorial and cell‐type‐specific functions, the regulation of their expression involves complex mechanisms 27,29 .…”

Diseases of cutaneous appendages

“…Seasonal factors, including temperature and light intensity, play some role in precipitating molting in certain animals. 711,712 A reduction in bcl-2 expression also occurs during catagen. 701 Recent studies have addressed this issue of the 'hair cycle clock'.…”

Expression of the High-Affinity Choline Transporter, CHT1, in the Neuronal and Non-neuronal Cholinergic System of Human and Rat Skin

“…This process includes apoptotic secretion that is regulated by cholinergic signaling (Nguyen et al, 2001). Similarly, CHT1 immunoreactivity was prominent in a ring in the internal root sheath, which corresponds in location to the so-called``upper ring'' where the cells switch to terminal differentiation followed by exfoliation in the pilary canal (Barajon et al, 2001). Collectively, these data are in favor of a crucial involvement of CHT1 in the cholinergic signaling pathways regulating keratinocyte differentiation processes.…”