Pattern of F-18 FDG Uptake in Colon Cancer after Bacterial Cancer Therapy Using Engineered <i>Salmonella Typhimurium</i>: A Preliminary <i>In Vivo</i> Study

Chong, Ari; Nguyen, Dinh-Huy; Kim, Hyeon Sik; Chung, June‐Key; Min, Jung‐Joon

doi:10.1155/2022/9222331

Cited by 6 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, (Chong et al., 2022 ) explored the uptake pattern of 18F‐fluoro‐D‐glucose (18F‐FDG) PET in mouse CT26 tumour models before and after BCT, which indicated that the higher the rate of FDG tumour uptake before BCT is, the better the BCT response is. FDG uptake pattern was associated with tumour volume change after BCT, so an assessment based on the FDG uptake can be used to evaluate the efficacy of BCT.…”

Section: Bacteria Imaging In Tumour Diagnosismentioning

confidence: 99%

Bacterial imaging in tumour diagnosis

Chu,

Yu,

Jiang

et al. 2024

Microbial Biotechnology

View full text Add to dashboard Cite

Some bacteria, such as Escherichia coli (E. coli) and Salmonella typhimurium (S. typhimurium), have an inherent ability to locate solid tumours, making them a versatile platform that can be combined with other tools to improve the tumour diagnosis and treatment. In anti‐cancer therapy, bacteria function by carrying drugs directly or expressing exogenous therapeutic genes. The application of bacterial imaging in tumour diagnosis, a novel and promising research area, can indeed provide dynamic and real‐time monitoring in both pre‐treatment assessment and post‐treatment detection. Different imaging techniques, including optical technology, acoustic imaging, magnetic resonance imaging (MRI) and nuclear medicine imaging, allow us to observe and track tumour‐associated bacteria. Optical imaging, including bioluminescence and fluorescence, provides high‐sensitivity and high‐resolution imaging. Acoustic imaging is a real‐time and non‐invasive imaging technique with good penetration depth and spatial resolution. MRI provides high spatial resolution and radiation‐free imaging. Nuclear medicine imaging, including positron emission tomography (PET) and single photon emission computed tomography (SPECT) can provide information on the distribution and dynamics of bacterial population. Moreover, strategies of synthetic biology modification and nanomaterial engineering modification can improve the viability and localization ability of bacteria while maintaining their autonomy and vitality, thus aiding the visualization of gut bacteria. However, there are some challenges, such as the relatively low bacterial abundance and heterogeneously distribution within the tumour, the high dimensionality of spatial datasets and the limitations of imaging labeling tools. In summary, with the continuous development of imaging technology and nanotechnology, it is expected to further make in‐depth study on tumour‐associated bacteria and develop new bacterial imaging methods for tumour diagnosis.

show abstract

Section: Bacteria Imaging In Tumour Diagnosismentioning

confidence: 99%