Pattern of Growth Hormone Secretion During a 24-Hour Fast in Normal Adults

Quabbe, H.-J.; Schilling, Erich; Helge, H

doi:10.1210/jcem-26-10-1173

Cited by 180 publications

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“…These findings confirm similar findings by Quabbe et al (9), and provide additional evidence against the view of Hunter, Friend, and Strong (7) that the secretion of GH during sleep is primarily determined by the need to mobilize stored nutrients during night fasting. Likewise, we have also failed to observe acute changes in plasma free fatty acids which correlated with the major peaks of GH secretion during sleep (unpublished observations).…”

Section: Resultssupporting

confidence: 91%

“…In the six control studies carried out on the four male subjects, the plasma GH concentration, after the initial GH peak, remained at 5 mpg/ml or less for the remainder of the night except for one study in subject T. F. in which a secondary rise to 6 mpg/ml was noted. In the female subjects, with the exception of subject F. R. noted below, at least one and in some instances two subsequent GH peaks ranging from [8][9][10][11][12][13][14][15][16][17][18][19][20] mpg/ml were regularly observed. The peaks were usually sharply defined and limited in duration with return to basal levels (< 5 mpg/ml) before subse- the initial plasma GH peak was: always considerably greater than the subsequent elevated level.…”

Section: Resultsmentioning

confidence: 99%

“…A more detailed study of plasma GH concentrations in sleep was carried out by Quabbe, Schilling, and Helge (9) in six normal adult subjects.…”

Section: Introductionmentioning

confidence: 99%

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Growth hormone secretion during sleep

Takahashi¹,

Kipnis²,

Daughaday³

1968

J. Clin. Invest.

766

268

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Plasma growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults. Blood was drawn from an indwelling catheter at 30-min intervals; EEG and electrooculogram were recorded throughout the night. In seven subjects, a plasma GH peak (13-72 mug/ml) lasting 1.5-3.5 hr appeared with the onset of deep sleep. Smaller GH peaks (6-14 mug/ml) occasionally appeared during subsequent deep sleep phases. Peak GH secretion was delayed if the onset of sleep was delayed. Subjects who were awakened for 2-3 hr and allowed to return to sleep exhibited another peak of GH secretion (14-46 mjug/ml). Peak GH secretion was not correlated with changes in plasma glucose, insulin, and cortisol. The effects of 6-CNS-active drugs on sleep-related GH secretion were investigated. Imipramine (50 mg) completely abolished GH peaks in two of four subjects, whereas chlorpromazine (30 mg), phenobarbital (97 mg), diphenylhydantoin (90 mg), chlordiazepoxide (20 mg), and isocarboxazid (30 mg) .did not inhibit GH peaks. Altered hypothalamic activity associated with initiation of sleep results in a major peak of growth hormone secretion unrelated to hypoglycemia or changes in cortisol and insulin secretion.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

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Growth hormone secretion during sleep

Takahashi¹,

Kipnis²,

Daughaday³

1968

J. Clin. Invest.

766

268

View full text Add to dashboard Cite

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“…However, comparisons between these two types of preparations are difficult for the reasons stated above, and those studies in which a stimulating influence of glucose on the human forearm was shown do not exclude the possibility that this effect is secondary to an increase in plasma insulin. In regard to the effect of growth hormone, we do not know if the usually low concentrations with sudden increments, characteristic of plasma growth hormone after an overnight fast (21), influence the glucose uptake in the human forearm to any significant extent.…”

Section: Discussionmentioning

confidence: 99%

The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics

Christensen¹,

Ørskov²

1968

J. Clin. Invest.

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“…Serial measurements of plasma GH levels in man and experimental animals show abrupt, spontaneous fluctuations (1,14,15). For these oscillations to occur, the hypothalamic-pituitary connections must be intact (16).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Episodic Growth Hormone Secretion by the Central Epinephrine System

Terry

Crowley

Johnson³

1982

J. Clin. Invest.

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A B S T R A C T Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Extensive pharmacologic studies in man and animals indicate a stimulatory effect of central norepinephrine and dopamine on GH, but the function of epiphephrine (EPI) is uncertain. Furthermore, many of the agents used to study the role of catecholamines in GH regulation are not selective in that they affect adrenergic as well as noradrenergic and/or dopaminergic neurotransmission. In the present investigation, central nervous system (CNS) EPI

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Pattern of Growth Hormone Secretion During a 24-Hour Fast in Normal Adults

Cited by 180 publications

References 0 publications

Growth hormone secretion during sleep

Growth hormone secretion during sleep

The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics

Regulation of Episodic Growth Hormone Secretion by the Central Epinephrine System

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