Pattern of hospitalizations for angioedema in New York between 1990 and 2003

Lin, Robert Y.; Cannon, A.G.; Teitel, Ariel D.

doi:10.1016/s1081-1206(10)61206-9

Cited by 45 publications

(25 citation statements)

References 28 publications

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“…8 The authors proposed that the increases could be a result of increasing exposure to environmental risk factors (eg, peanuts, other foods, or latex), a lower threshold for sensitization to these allergens in the population, or both. Similar findings have been reported in the United States 9 and Australia. 10 Although these conditions are a particularly serious problem for children and young adults, they can affect persons of all ages.…”

supporting

confidence: 91%

Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005

Poulos¹,

Waters²,

Correll³

et al. 2007

Journal of Allergy and Clinical Immunology

327

242

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supporting

confidence: 91%

Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005

Poulos¹,

Waters²,

Correll³

et al. 2007

Journal of Allergy and Clinical Immunology

327

242

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“…However, AE has been reported as the most frequent cause of hospital admission among all acute, allergic, nonasthmatic diseases [30] . We thus investigated different forms of recurrent AE, unaccompanied by wheals, in consecutive patients referred during the last 3 years to the outpatient clinic of our tertiary-level center.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Angioedema: Occurrence, Features, and Concomitant Diseases in an Italian Single-Center Study

Triggianese

Guarino²,

Pellicano³

et al. 2017

Int Arch Allergy Immunol

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Background: Angioedema (AE) is a potentially life-threatening condition with hereditary (HAE), acquired (AAE), or iatrogenic causes. A careful workup allows for the identification of the etiology of attacks and the appropriate management. In this cohort study, based on a clinical practice setting, we aimed at investigating clinical and laboratory findings concerning different features of patients with recurrent AE who were referred to a single, tertiary-level center for HAE. Methods: Clinical and laboratory data of patients fulfilling the criteria for C1-inhibitor-deficient HAE (C1-INH-HAE), C1-INH-AAE, angiotensin-converting enzyme inhibitor-related AE (ACEI-RA), and idiopathic AAE (I-AAE) were evaluated. Descriptive statistics were analyzed by means of the Mann-Whitney U test. The Fisher exact test was used for group comparisons. Results: Patients were diagnosed with type 1 HAE (n = 14), type 2 HAE (n = 1), C1-INH-AAE (n = 8), ACEI-RA (n = 16), or I-AAE (n = 26). We included only patients with concomitant autoimmune diseases from the I-AAE group (n = 8, aut-I-AAE). Age at disease onset and at diagnosis was younger in type 1 HAE than in all the other groups. The diagnostic delay was longer in type 1 HAE than in ACEI-RA. C4 and C1q levels were lower in C1-INH-AAE than in type 1 HAE, ACEI-RA, and aut-I-AAE. Both HAE and C1-INH-AAE showed lower C1-INH antigen and function compared to the other groups. Peripheral attacks were more frequent in type 1 HAE, while airway, abdominal, and oral attacks were prevalent in C1-INH-AAE. Conclusion: Investigating the clinical and laboratory features of recurrent AE without wheals represents a major topic for facilitating early diagnosis and improving treatment strategies for this heterogeneous and misdiagnosed condition.

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“…The commonly applied label of "allergic" is frequently wrong, and standard anti-allergic therapeutic approaches can be totally ineffective. The growing relevance of this condition has been highlighted, moreover, by a recent study 7 that showed that angioedema is the most frequent cause of hospital admission of all acute allergic, nonasthmatic diseases.…”

Section: Discussionmentioning

confidence: 99%

Angioedema without urticaria: a large clinical survey

Zingale¹,

Beltrami²,

Zanichelli³

et al. 2006

Canadian Medical Association Journal

186

158

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A ngioedema -a self-limited, localized swelling that involves subcutaneous tissues or mucosa -can involve the face and other areas. Skin colour is usually unchanged, although it may be heralded by erythema marginatum. There is no burning sensation and itchiness is generally absent. Lesions tend to be large and without clear demarcation; most resolve within 2 or 3 days. 1Frequently the result of the release of histamine, angioedema is often associated with urticarial flares (hives; the association is often called urticaria-angioedema syndrome) and responds to antihistamines and corticosteroids.2 Occasionally, angioedema occurs without urticaria, does not respond to drugs against allergies and tends to last 5-7 days -for example, when it is caused by a deficiency in plasma of C1 esterase inhibitor (C1Inh).To investigate and form classifications for different forms of angioedema unaccompanied by urticaria, we analyzed 929 consecutive patients referred to our university hospital over an 11-year period (January 1993 through December 2003). MethodsOur outpatient clinic for angioedema is a tertiary-level centre where patients are referred mostly by specialists. All clinic patients with a history of recurrent angioedema without major urticaria between January 1993 and December 2003 were considered for the study.From each patient, we obtained a clinical history with information about allergies and their relation to potential causative agents (e.g., foods, drugs, chemicals) and carried out a complete physical examination. We obtained sinus and dental radiographs as well as test results for blood cell count, serum protein electrophoresis, erythrocyte sedimentation rate, Creactive protein, hepatic enzymes, renal function, thyroid function and anti-tissue antibodies (antinuclear antibodies and antibodies to extractable nuclear antigens, to doublestranded DNA, to thyroglobulin and to thyroperoxidase). Stool examinations (for ova and parasites) and urinanalyses were carried out, and pharyngeal and urine samples were cultured. Further specific analyses were performed if deemed necessary.If all test results were negative, response to long-term H1-

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Pattern of hospitalizations for angioedema in New York between 1990 and 2003

Cited by 45 publications

References 28 publications

Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005

Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005

Recurrent Angioedema: Occurrence, Features, and Concomitant Diseases in an Italian Single-Center Study

Angioedema without urticaria: a large clinical survey

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