Pattern of inpatient referrals to a drug allergy unit in Kuwait

Evaluation of the frequency and characteristics of drug hypersensitivity reactions in hospitalized children: Real life-cohort study

“…This rate increased to 0.1% in antimicrobials and antibiotics and to 0.2% in chemotherapeutics. Consistent with previous studies, 4 , 26 antimicrobials were the most commonly suspected drugs (48%). The high frequency of suspected DHR with antimicrobials may be due to the high frequency of admissions for infection in pediatric patients and the fact that antimicrobials are the most commonly used drugs.…”

“… 1 , 2 Few studies on DHR, which occurred de novo at the hospital, and their management in pediatric inpatients have been published. 3 , 4 …”

Recent developments and highlights in drug hypersensitivity

“…The clinical entities induced differ based on the culprit drug. In the case of anaphylaxis, the most frequent elicitors are nonsteroidal anti‐inflammatory drugs (NSAIDs), antibiotics (both betalactams [BLs] and non‐BLs), radiocontrast media and anaesthetic agents . Regarding SCARs, the drugs involved depend on the population (adults or children).…”

“…One important problem is the low rate of confirmed cases after the allergy evaluation, 10%‐30% in penicillin allergy, 21% in NSAIDs hypersensitivity and none of 164 patients with suspected IRs to local anaesthetics . This indicates the need to accurately evaluate these patients to reduce unnecessary inpatient/outpatient use of second‐line treatments that may otherwise produce greater use of hospital resources .…”

“…In the case of anaphylaxis, the most frequent elicitors are nonsteroidal antiinflammatory drugs (NSAIDs), antibiotics (both betalactams [BLs] and non-BLs), radiocontrast media and anaesthetic agents. [6][7][8][9] Regarding SCARs, the drugs involved depend on the population (adults or children). In this sense, antibiotics and anticonvulsants are the most common ones in adults 10 ; and antibiotics, NSAIDs, and chemotherapeutics 11 as well as aromatic anticonvulsants and also allopurinol are the most frequently involved in children.…”