Pattern of Intracranial Space-Occupying Lesions: The Experience of the King Khalid University Hospital

Jamjoom, Zain Alabedeen B.

doi:10.5144/0256-4947.1989.3

Cited by 22 publications

(25 citation statements)

References 24 publications

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“…[1][2][3] These figures are higher than those reported from European and Asian countries, [5][6][7][8][9][10] but comparable to the percentages derived from Africa. [11][12][13] Both age and sex distributions of our patients are within the reported limits.…”

Section: Discussioncontrasting

confidence: 50%

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Intracranial Meningiomas: Analysis of 53 Consecutive Cases with Special Reference to their Operability and Surgical Outcome

et al. 1990

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Fifty-three cases of intracranial meningiomas were retrospectively analyzed with regard to the age and sex distribution, anatomic location, mode of presentation, surgical management, and outcome. Patient age ranged from 25 to 80 years (average, 47.7 years); overall male to female ratio was 1:1.9. Tumor locations were: 26.4% sphenoidal ridge, 20.8% convexity, 17% sagittal or parasagittal, 13.2% olfactory groove, 11.3% suprasellar, 9.4% infratentorial, and 1.9% multiple. Delayed diagnosis and referral were common and accounted for a higher number of patients with severe neurologic deficit and blindness. Forty-two patients underwent 47 surgical procedures for tumor removal; 38 were first operations and 9 were for recurrences. Tumor removal was total in 61% of the first and 33% of the repeat operations; the highest rates were achieved for lesions in the convexity (100%) and the lowest for basal (29%) meningiomas. Outcome following first surgery was excellent in 37%, good to satisfactory in 39%, and poor in 8% of the cases. There was a total of 6 (16%) postoperative deaths; however, the 30-day postoperative mortality was 5.3%. The recurrence rate was 5.6% after total and 30% after partial resection. Our results emphasize the importance of early diagnosis and treatment of intracranial meningiomas.

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Section: Discussioncontrasting

confidence: 50%

“…[1][2][3] However, data concerning the age and sex distributions, anatomic locations, mode of presentation, and standards of management of meningioma in Saudi Arabia have been deficient. This has prompted our study of intracranial meningiomas in this country.…”

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Intracranial Meningiomas: Analysis of 53 Consecutive Cases with Special Reference to their Operability and Surgical Outcome

et al. 1990

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“…Most of them were small, and they reported all types of brain tumors including meningioma, pituitary adenomas, brain metastasis…etc. The percentage of neuro-epithelial brain tumors in these studies were quite small to make any statistical comparisons [11][12][13] One study from King Fahad University Hospital (KFUH) -Al-Khobar in the Eastern province of Saudi Arabia had a larger sample with a sizable percentage of neuro-epithelial brain tumors. The study included all CNS tumors according to the WHO classifications (1979 edition).…”

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confidence: 99%

Demographic and histopathological patterns of neuro-epithelial brain tumors in Eastern Province of Saudi Arabia

Taha

Almsned

Hassen

et al. 2018

NSJ

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Methods: This is a retrospective chart-review study of all patients with neuro-epithelial brain tumors referred and treated in our center between January 2010 and January 2015. The age, gender, tumor location, and histopathology were recorded. Results:The total number of cases was 149 including 96 adult cases and 53 pediatric cases. 58% of cases were male, and 42% were female. The age group distribution showed 2 peaks; one in the first 5 years of life and the second was in the age range from 26-45 years old. Glioblastoma multiforme was the most common pathological type (32%), followed by medulloblastoma (13.3%). This study showed similar results to a previous study conducted in the Eastern Province in terms of age and gender distribution, but pathologically, the tumors diagnosed in our study were generally of a higher grading.

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“…7,9,11,[13][14][15] The reason for the low number of females among our patients is not clear, considering that the overall male-to-female ratio for all pituitary adenomas treated in our unit was within the ranges reported by other authors. 16 It is possible, however, that the high proportion of non-Saudi acromegalic patients in this series have played a role. A recent census in 1992 revealed that 70.4% of all non-Saudis residing in Saudi Arabia were males.…”

Section: Discussionmentioning

confidence: 70%

Growth Hormone Secreting Pituitary Adenoma: Clinical Aspects and Surgical Outcome

et al. 1995

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A series of 18 consecutive patients with growth hormone-secreting pituitary adenoma treated by surgery were analyzed retrospectively. Apart from an unusually high male-to-female ratio, the demographic data, clinical presentation, and endocrinological findings were similar to those reported by other authors. There were four (22%) microadenomas and 14 (78%) macroadenomas with a large intracranial extension in three patients and gross radiological evidence of invasion of surrounding structures in three others. The mean preoperative basal serum growth hormone level was 48.6 ± 45.4 ng/mL. The tumor resection was carried out via a transsphenoidal route in 15 cases and via frontotemporal craniotomy in the remaining three. One patient died from pulmonary embolism ten days after transcranial tumor resection. The mean postoperative basal growth hormone level was 10.0 ± 10.4 ng/mL. The growth hormone level decreased below 5 ng/mL in six of the 17 survivors (35%) directly after surgery. Nine patients received adjuvant postoperative treatment as follows: dopamine agonist in four, somatostatin analog in one, radiotherapy in one, and a combined drug and radiotherapy in three. The postoperative follow-up period ranged between two and 55 months (mean 28.6). At last follow-up examination, 10 (59%) patients had normalized their basal growth hormone level. Two patients developed postoperative anterior pituitary lobe insufficiency and a third had permanent diabetes insipidus.Acromegaly is a serious medical disorder resulting from the unrestrained secretion of growth hormone (GH). The long-term effects of sustained excess of GH on metabolism and cardiovascular system are deleterious and include diabetes mellitus, arterial hypertension, heart disease, as well as an increased risk of malignancy.1-3 The mortality associated with untreated or partially treated acromegaly is double to threefold the expected rate in healthy subjects matched for age. 4,5 Acromegaly may be caused by a variety of pathological conditions, but GH-secreting pituitary adenomas are by far the most common. 6 The medical literature is rich with reports covering various aspects of this lesion; 4,[7][8][9][10][11][12] however, published data about experiences with this tumor and its management in Saudi Arabia have been lacking entirely. This has prompted us to review all cases of GH-secreting pituitary adenomas which were operated upon in our institution during a period of 10 years and to compare our findings with the relevant data from the literature. Material and MethodsDuring a ten-year period starting in October 1982, 18 consecutive patients with previously untreated growth hormone-secreting pituitary adenoma underwent surgical removal of their tumors at the Neurosurgical Division of King Khalid University Hospital. They constituted 20.5% of all cases of pituitary adenoma treated there during the same period. The diagnosis of a pituitary adenoma was confirmed in all cases with computed tomography (CT) scan and, more recently, magnetic resonance imaging (MRI). A de...

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Pattern of Intracranial Space-Occupying Lesions: The Experience of the King Khalid University Hospital

Cited by 22 publications

References 24 publications

Intracranial Meningiomas: Analysis of 53 Consecutive Cases with Special Reference to their Operability and Surgical Outcome

Intracranial Meningiomas: Analysis of 53 Consecutive Cases with Special Reference to their Operability and Surgical Outcome

Demographic and histopathological patterns of neuro-epithelial brain tumors in Eastern Province of Saudi Arabia

Growth Hormone Secreting Pituitary Adenoma: Clinical Aspects and Surgical Outcome

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