Pattern of liver diseases among children attending the National Hospital Abuja, Nigeria

Ahmed, PA; Ulonnam, CC; Mohammed-Nafi’u, R.; Ballong, J; G, Nwankwo

doi:10.4314/njp.v43i1.9

Cited by 5 publications

(8 citation statements)

References 6 publications

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“…The most common sign noted was icterus (51.1%), hepatomegaly (42%), followed by ascitis and splenomegaly (26.6%) each. Similarly, a study done in Nigeria has shown jaundice (71.4%), abdomen pain (40.5%) as the most common symptoms and jaundice (71.4%) , hepatomegaly (38.1%), splenomegaly (19%) as the most common signs [2].…”

Section: Discussionmentioning

confidence: 78%

“…The outlook of hepatobiliary disorders has undergone tremendous change with advent of better diagnostic tools like ultrasound, radionuclear scan, viral and autoimmune markers, endoscopic retrograde cholangiography, digital substraction angiography and improved sectioning and staining techniques of liver tissue specimens [1]. Diseases of the liver contribute [2]. Liver diseases among children include a broad spectrum of disorders such as infections, developmental abnormalities and metabolic disorders that finally result in hepatic dysfunction and cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

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Magnitude, clinical spectrum and etiology of hepatobiliary disorders in children- a tertiary care experience

Maheswari

Manikandasamy

et al. 2017

Int J Pediatr Res

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Objectives: This study was undertaken to know about the magnitude, clinical spectrum and etiology of liver diseases in children in a tertiary care teaching hospital. Materials and Methods: This is a hospital based, retrospective, descriptive study. It was done on 45 children with hepatobiliary diseases admitted to pediatric department of Velammal Medical College, Madurai from Jan 2016-Dec 2016. Results: As about 45 children out of 2259 pediatric admissions, had hepatobiliary disorders. This was contributing to 1.99% of total admissions. Liver function test was deranged in (73.3%) of children. Males (62.2%), outnumbered, females (37.7%) in our study. Children less than 5 years of age were most commonly affected (46.6%). Most common symptom in children with hepatobiliary disorders were jaundice (51.1%), nausea/vomiting (46.6%), anorexia (40%), pain abdomen (33.3%), high coloured urine (28.8%), bleeding manifestations and abdomen distension in (20%) each, fever in (17.7%), failure to thrive and irritability in (15.5%) each. The most common sign observed was icterus (51.1%), hepatomegaly (42.2%). Ascitis and splenomegaly was noted in (26.6%) each, edema in (20%) and pallor in (15.5%) of children. Acute liver diseases were more common (68.8%) than chronic liver diseases (31.1%). The most common etiology of acute liver disease was acute viral hepatitis (28.8%), cholelithiasis (22.2%), non-alcoholic fatty liver disease (6.6%), liver abscess (4.4%), acute viral hepatitis with acalculous cholecystitis in (4.4%), acute liver failure due to paracetamol poisoning in (2.2%) of children. Etiology noted for chronic liver diseases were biliary atresia (13.3%), idiopathic cirrhosis and wilsons disease in (6.6%) each, autoimmune hepatitis and chronic hepatitis in (2.2%) each. Conclusion: Since age is the single most important determinant in successful management of biliary atresia, recognition and definitive identification of the condition as the cause of neonatal cholestasis syndrome in a given case very early after the onset of symptoms is of paramount importance.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Magnitude, clinical spectrum and etiology of hepatobiliary disorders in children- a tertiary care experience

Maheswari

Manikandasamy

et al. 2017

Int J Pediatr Res

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“…However, hepatitis C infection was the cause of CLD in 31.66% of children in the Tahir et al (19) investigation. And in a research from Nigeria by Ahmed et al [20], 57.1 percent of the children tested with viral aetiology were CLDs. There have been 21.4 percent non-infectious instances of bile atresia, cholestatic hepatitis, hepatoblastoma and galactosaemia.…”

Section: Discussionmentioning

confidence: 95%

“…This case-control study was carried out on 60 children who attended the outpatient hepatology clinic at Benha university hospitals and National liver institute, Menoufia University after informed written consent was obtained from the parents or caregivers of enrolled children after explanation of the study, the laboratory work was done in clinical pathology department, Benha University. 20…”

Section: Methodsmentioning

confidence: 99%

Diagnostic value of MMP-1 in chronic liver diseases

ElBakry

Mansour

Abdelrahman

et al. 2021

Benha Journal of Applied Sciences

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Background: Chronic liver disorders in children constitute an increasing concern with major public health impacts, the MMP is degrading diverse extracellular matrix macromolecules and involves tissue reshaping and repair in physiological processes. The purpose of this research was to assess the diagnostic usefulness of MMP-1 in children with chronic liver disorders. Methods: 60 children undertook this research; Group I (hepatic group): 60 children with chronic liver disease, Group II (control group): 20 seemingly healthy youngsters, The entire history of taking, comprehensive clinical examination, abdominal US and laboratory testing like a complete blood count and liver function tests have been performed for all children (Alt, AST, Albumin, PT, PTT, INR, Total and direct bilirubin), Liver biopsy was conducted in all patients, with human enzyme-connected immunosorbent testing measuring Serum MMP-1 levels (ELISA). Results: the mean MMP-1 in hepatic group was 11.2±2.1 ng/ml and in control group 32.7±17.4 ng/ml. In the hepatic group controlled, p<0.001, MMP-1 was statistically lower in order to measure the performance of MMP-1 in liver fibrosis (>F1), AUC was 0.872 (95 percent confidence interval: 0.709-0.487), p<0.001. Sensitivity was 95% at a cutoff threshold < 11.3 ng/ml and specificity was 95%. ROC testing was conducted to evaluate MMP-1 performance in detecting severe liver fibrosis (>F3); AUC p<0.001. The sensitivity was 90% at cutoff point < 4.5 ng/ml and the specificity was 80%. Conclusion: Fibrosis identification in children with chronic liver disorders might benefit from MMP-1.

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“…8 In our study 70% of the children were five years of age or older (59/84) compared to study from Nigeria showing 62% of the children in this age group. 9 The differences in mean age, gender distribution and age distribution reflect <0.001 Table-III the regional population differences of these countries. Chronic liver disease comprised 58.3% (49/84) of the cases followed by 34.5% (29/84) of the cases with acute hepatitis in our cohort.…”

Section: Discussionmentioning

confidence: 96%

Wilson disease in children; frequency and comparison with non-wilson etiology of liver diseases.

Khalid

Rasheed

2020

TPMJ

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Wilson disease is an autosomal disorder with wide-ranging clinical expressions. It mainly impinges on liver, brain, kidney and cornea. Objectives: The primary objective was to determine the frequency of Wilson disease; it’s clinical, biochemical features and outcome. The secondary objective was to compare children diagnosed with Wilson disease to those with non – Wilson etiology. Study Design: A comparative cross-sectional hospital-based study. Setting: Department of Pediatric Medicine Nishtar Hospital Multan. Period: From January 2017 to December 2017. Material & Methods: Children age 1 – 15 years presenting with hepatic manifestations (jaundice, bleeding, ascites and encephalopathy) were included in the study. Final diagnosis, clinical and biochemical features along with outcome were noted. We calculated mean and standard deviation for continuous variables and frequency and percentages for categorical variable. Results: Total 84 children with hepatic manifestations were admitted during study period. Mean age was 7.21 years (± 3.21). Males comprised 63.1% (53/84) of the study population. Wilson disease was diagnosed in 27 (32.14%) patients. Infective etiologies included Hepatitis A, B, C and E. Most common clinical presentation was that of chronic liver disease in 58.3% (49/84). Most common sign and symptom was Jaundice (97.6%). Mean age was higher in children with Wilson disease compared to non – Wilson group (9.3 vs. 6.2). Mean serum ceruloplasmin in children with Wilson disease was 15.93 mg/dl (± 4.66) whereas mean urinary copper (µg/24 hr.) before and after Vistamine challenge were 131.1 (±47.66) and 1250.4 (± 194.43). Kayser – Fleischer rings were present in 11 (40.74%) children with Wilson disease. Mortality rate was 7.1 % (6/84) in study population and 11.1% (3/27) in children with Wilson disease. Conclusion: Wilson disease is not an infrequent diagnosis in our setup but has multiple masquerading presentations. A high index of suspicion is required to consider and investigate for Wilson disease as a possible and the treatable cause of hepatic manifestations.

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Pattern of liver diseases among children attending the National Hospital Abuja, Nigeria

Cited by 5 publications

References 6 publications

Magnitude, clinical spectrum and etiology of hepatobiliary disorders in children- a tertiary care experience

Magnitude, clinical spectrum and etiology of hepatobiliary disorders in children- a tertiary care experience

Diagnostic value of MMP-1 in chronic liver diseases

Wilson disease in children; frequency and comparison with non-wilson etiology of liver diseases.

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