Pattern of liver diseases in Oman

Al-Lawati, Taha; George, Magdalene; Al-Lawati, F. A. R.

doi:10.1179/027249309x12467994693770

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…The prevalence of hypertension among the Omani population has increased from 27% in 1995 to 32% in 2000. 13 In the current study, only 21% of the studied patients had normal blood pressure, andprehypertension is shown to be a common disease among the studied group (45%). This finding may not be so surprising given the current increase in the prevalence of chronic diseases and their related risk factors in the sultanate of Oman; of which, approximately 75% of the disease burden is attributable to non-communicable diseases.…”

Section: Discussionmentioning

confidence: 47%

Prevalence and Determinants of Pre-Hypertension among Omani Adults Attending Non-Communicable Disease Screening Program in Primary Care Setting in Sohar City

Al-Maqbali

Temple-Smith²,

Ferler³

et al. 2013

Oman Med J

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Section: Discussionmentioning

confidence: 47%

Prevalence and Determinants of Pre-Hypertension among Omani Adults Attending Non-Communicable Disease Screening Program in Primary Care Setting in Sohar City

Al-Maqbali

Temple-Smith²,

Ferler³

et al. 2013

Oman Med J

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“…In addition, in Oman, progressive familial intrahepatic cholestasis (30%) and fibrocystic diseases of the liver and kidneys (21%) were the most common causes of liver fibrosis (16) .…”

Section: Discussionmentioning

confidence: 99%

Von Willebrand Factor; a New Non-Invasive Marker for Assessment of Liver Fibrosis in Infants and Children

Abdelrazek¹,

Mansour²,

Barakat³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Von Willebrand Factor (vWF) is a multimeric adhesive protein to which platelets stick. It is physiologically released by activated endothelial cells during primary hemostasis. High Shear stress induced by hyperdynamic (splanchnic) circulation in advanced hepatic fibrosis as well as endotoxinemia caused by bacterial translocation may contribute to the increased levels of vWF releasing from that activated endothelium. Objective: The aim of the current work was to assess the stage of fibrosis changes in children with CLD noninvasively by measuring the levels of serum Vwf Ag. Patients and Methods: This was an observational case control study conducted on sample of 40 infants and children up to 18 years divided into two equal groups of 20 cases (fibrotic) attending hepatic clinic at Mansoura University Children' Hospital and another 20 healthy matched controls. The diagnosis of fibrosis was previously verified by clinical, biochemical, ultrasonographic criteria and biopsy. Results: There was highly statistically significant increase in vWF value in the cases compared to the controls (167.1  47.8 Vs 112.9  36.1 IU/dL) (P<0.001). vWF Ag values demonstrated insignificant differences concerning etiology of liver disease, presence or absence of ascites and hepatosplenomegaly (P>0.05). Values of vWF Ag were demonstrated to be significantly increases in cases with severe fibrosis as well as cases with varices (P<0.05). There were highly statistically significant correlations between vWF Ag level and both fibrosis stage and Child Score among the studied patients (P≤0.001). Conclusion:It could be concluded Willebrand factor antigen level was positively correlated with liver function tests as well as varices and could be used as a significant predictor to severity of liver fibrosis and / or cirrhosis in children and infants with chronic liver disease.

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“…Also, in Japan the main causes of liver cirrhosis in children who underwent liver transplantation were biliary atresia (72.9%), cryptogenic (8.1%), Budd Chiari syndrome (5.4%), progressive familial intrahepatic cholestasis (5.4%), and Wilson disease (2.7%). 26 In a nationwide survey in Japan to evaluate the etiology of liver cirrhosis, the data from 33379 patients with liver cirrhosis were analyzed at 58 hospitals. The most common causes of cirrhosis were hepatitis B virus (13.9%), hepatitis C virus (60.9%), alcohol (13.6%), primary biliary cirrhosis (2.4%) and autoimmune hepatitis (1.9%).…”

Section: Discussion:-mentioning

confidence: 99%

Liver Cirrhosis in Children

Rabii¹,

Bourrahouat²,

Aitsab³

2020

IJAR

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Background :Liver cirrhosis is one of the major causes of hospitalization and mortality in children. A wide spectrum of disorders including developmental abnormalities, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. Determination of its etiology is important for treatment, prevention of progressive liver damage, family counseling and prioritizing liver transplantation. The aim of this study is to evaluate etiological and prognostic aspects of liver cirrhosis in children at the pediatrics department at the university hospital center of Marrakech. Methods :We included all cirrhotic children under the age of 15 who were hospitalized in the gastro-pediatric department at the University Hospital Center of Marrakech over a period from January 2012 to December 2018 in this retrospective study. The etiology of cirrhosis was determined based on clinical results, laboratory tests, imaging studies mainly by ultrasound and histopathological examination of the liver biopsy. Results :A total of 78 cirrhotic children aged 1 month to 12 years with an average age of 3 years and 5 months, including 43 boys (55%) and 35 girls (45%) were enrolled in the study. The most common causes of liver cirrhosis were: 20 cases of Wilson's disease, biliary atresia in 16 cases, 5 cases of glycogenosis, 3 cases of PFIC, 2 cases of sclerosing cholangitis, 2 cases of tyrosinemia, 2 cases of alpha 1 antitrypsin deficiency, one case of hepatitis B, one case of autoimmune hepatitis, one case of cirrhosis on celiac disease and one case of hemochromatosis. In 31% of cases, the cause of cirrhosis was unknown. Conclusion :Given the two most common pathologies of cirrhosis of the liver in children in this region of Morocco, we suggest an earlier diagnosis for these two pathologies.

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Pattern of liver diseases in Oman

Abstract: About half of the chronic liver disorders in Oman are hereditary in origin. At least three children per year will require liver transplant.

Cited by 8 publications

References 12 publications

Prevalence and Determinants of Pre-Hypertension among Omani Adults Attending Non-Communicable Disease Screening Program in Primary Care Setting in Sohar City

Prevalence and Determinants of Pre-Hypertension among Omani Adults Attending Non-Communicable Disease Screening Program in Primary Care Setting in Sohar City

Von Willebrand Factor; a New Non-Invasive Marker for Assessment of Liver Fibrosis in Infants and Children

Liver Cirrhosis in Children

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