Pattern of matrix metalloproteinases-9, P53 and BCL-2 proteins in Egyptian patients with pulmonary<i>Mycobacterium tuberculosis</i>

El‐Masry, Samir; Lotfy, Mahmoud; Samy, Mona; Moawia, S.; Elsayed, Ibrahim; Khamees, Islam M

doi:10.1556/amicr.57.2010.2.5

Cited by 6 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung cancer [68] Releasing the NO; [69] upregulating P53 and Bcl-2. [70] Campylobacter jejuni CRC, [71] small intestinal lymphomas [72] Promoting CRC through the genotoxic action of cytolethal distending toxin. [71] Propionibacterium acnes Prostate cancer [73] Promoting M2 polarization of macrophages via TLR4/PI3K/Akt signaling.…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context

Liu

Niu

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Targeted therapy and immunotherapy have brought hopes for precision cancer treatment. However, complex physiological barriers and tumor immunosuppression result in poor efficacy, side effects, and resistance to antitumor therapies. Bacteria‐mediated antitumor therapy provides new options to address these challenges. Thanks to their special characteristics, bacteria have excellent ability to destroy tumor cells from the inside and induce innate and adaptive antitumor immune responses. Furthermore, bacterial components, including bacterial vesicles, spores, toxins, metabolites, and other active substances, similarly inherit their unique targeting properties and antitumor capabilities. Bacteria and their accessory products can even be reprogrammed to produce and deliver antitumor agents according to clinical needs. This review first discusses the role of different bacteria in the development of tumorigenesis and the latest advances in bacteria‐based delivery platforms and the existing obstacles for application. Moreover, the prospect and challenges of clinical transformation of engineered bacteria are also summarized.

show abstract

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context

Liu

Niu

et al. 2023

Advanced Science

View full text Add to dashboard Cite

show abstract

“…Previous studies demonstrate that matrix metalloproteases (MMPs) have a unique ability to degrade fibrillar collagen at neutral pH leading to lung matrix destruction [81–85]. MMP activity was dependent upon a monocyte-epithelial cell network and p38 MAPK phosphorylation to achieve the matrix-degrading phenotype [83].…”

Section: Airway Epithelial Cells and Their Host Defensesmentioning

confidence: 99%

The Role of Airway Epithelial Cells in Response to Mycobacteria Infection

Wang

Liu

2012

Clinical and Developmental Immunology

View full text Add to dashboard Cite

Airway epithelial cells (AECs) are part of the frontline defense against infection of pathogens by providing both a physical barrier and immunological function. The role of AECs in the innate and adaptive immune responses, through the production of antimicrobial molecules and proinflammatory factors against a variety of pathogens, has been well established. Tuberculosis (TB), a contagious disease primarily affecting the lungs, is caused by the infection of various strains of mycobacteria. In response to mycobacteria infection, epithelial expression of Toll-like receptors and surfactant proteins plays the most prominent roles in the recognition and binding of the pathogen, as well as the initiation of the immune response. Moreover, the antimicrobial substances, proinflammatory factors secreted by AECs, composed a major part of the innate immune response and mediation of adaptive immunity against the pathogen. Thus, a better understanding of the role and mechanism of AECs in response to mycobacteria will provide insight into the relationship of epithelial cells and lung immunocytes against TB, which may facilitate our understanding of the pathogenesis and immunological mechanism of pulmonary tuberculosis disease.

show abstract

Activity of Matrix Metalloproteinases during Antimycobacterial Therapy in Mice with Simulated Tuberculous Inflammation

Sumenkova¹,

Russkikh²,

Poteryaeva

et al. 2013

Bull Exp Biol Med

View full text Add to dashboard Cite

Matrix metalloproteinases are shown to be involved in the pathogenesis of tuberculosis inflammation. In the early stages of BCG-granuloma formation in mouse liver and lungs, the serum levels of matrix metalloproteinases 2 and 7 increased by 4.5 times and remained unchanged while the pathology developed. Antimycobacterial therapy with isoniazid reduced enzyme activity almost to the level of intact control. The decrease in activity of matrix metalloproteinases 2 and 7 that play the most prominent role in the development of destructive forms of tuberculosis is of great therapeutic importance.

show abstract

Pattern of matrix metalloproteinases-9, P53 and BCL-2 proteins in Egyptian patients with pulmonaryMycobacterium tuberculosis

Cited by 6 publications

References 28 publications

Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context

Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context

The Role of Airway Epithelial Cells in Response to Mycobacteria Infection

Activity of Matrix Metalloproteinases during Antimycobacterial Therapy in Mice with Simulated Tuberculous Inflammation

Contact Info

Product

Resources

About