Pattern of Newborn Antibiotic Use in a Tertiary Level Maternity for Five Years

Dorobanțu, Florica Ramona; Hodoșan, Viviana; Tîrb, Alina Manuela; Zaha, Dana Carmen; Galușca, Dorina; Pop, Nicolae Ovidiu; Dorobanțu, Cătălin Dorin

doi:10.51847/pq4px0rkxg

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…Specific components of the microbial community can activate immune cells, leading to inflammatory responses and immune reactions closely associated with the occurrence and progression of arterial embolism and thrombosis. Notably, the rampant and indiscriminate use of antibiotics has resulted in heightened resistance to antimicrobial drugs, which in turn disrupts the gut microbiota of the host organism ( Dorobanțu et al, 2022 ; Păduraru et al, 2022 ). It is pertinent to consider whether these antibiotics could impact the 11 gut microorganisms identified in the study, potentially influencing thrombogenesis.…”

Section: Discussionmentioning

confidence: 99%

Genetic evidence for a causal link between gut microbiota and arterial embolism and thrombosis: a two-sample Mendelian randomization study

Shi,

Dong,

Chang

et al. 2024

Front. Microbiol.

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BackgroundPrevious research has hinted at a crucial link between gut microbiota and arterial embolism and thrombosis, yet the causal relationship remains enigmatic. To gain a deeper understanding, we aimed to comprehensively explore the causal relationship and elucidate the impact of the gut microbiota on the risk through a two-sample Mendelian randomization (MR) study.MethodsGenetic instrumental variables for gut microbiota were identified from a genome-wide association study (GWAS) of 18,340 participants. Summary statistics for IBS were drawn from a GWAS including 1,076 cases and 381,997 controls. We used the inverse-variance weighted (IVW) method as the primary analysis. To test the robustness of our results, we further performed the weighted median method, MR-Egger regression, and MR pleiotropy residual sum and outlier test.ResultsWe identified three bacterial traits that were associated with the risk of arterial embolism and thrombosis: odds ratio (OR): 1.58, 95% confidence interval (CI): 1.08–2.31, p = 0.017 for genus Catenibacterium; OR: 0.64, 95% CI: 0.42–0.96, p = 0.031 for genus Dialister; and OR: 2.08, 95% CI: 1.25–3.47, p = 0.005 for genus Odoribacter. The results of sensitivity analyses for these bacterial traits were consistent (P<0.05).ConclusionOur systematic analyses provided evidence to support a potential causal relationship between several gut microbiota taxa and the risk of arterial embolism and thrombosis. More studies are required to show how the gut microbiota affects the development of arterial embolism and thrombosis.

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Section: Discussionmentioning

confidence: 99%

Genetic evidence for a causal link between gut microbiota and arterial embolism and thrombosis: a two-sample Mendelian randomization study

Shi,

Dong,

Chang

et al. 2024

Front. Microbiol.

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“…A large part of these factors can be prevented, and nevertheless they are still decisive for the incidence of neonatal emergencies. In addition, the care of these newborns is more expensive [9].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Study on the Risk Factors for Resuscitation at Birth and Admission to the NICU in a Third Level Maternity

Dorobanțu,

Pop,

Zaha

et al. 2024

Preprint

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Neonatal mortality remains a public health concern and timely identification and prompt intervention in the delivery room could improve the outcome in neonatal morbidity and mortality. We performed a retrospective study to help us finding the profile of the high-risk newborn regarding the need for NICU admission, necessary to establish a protocol regarding the mobilization of human and material resources for the urgent management of these situations. All deliveries and neonates born in Maternity of Bihor County Emergency Clinical Hospital from Romania were reviewed, including relevant maternal, foetal and perinatal data to identify risk factors that result in birth of newborns needing resuscitation at birth between 2012-2019. The number of births showed a downward trend but around 90% of the births were on term. The incidence of neonatal emergencies is increasing, the most frequently were respiratory, sepsis and other infections, cardiovascular emergencies, and extreme prematurity. It is noted that in 2021 the incidence of these neurological emergencies increased by three times compared to previous years. The neonatal and maternal risk factors associated with admission to the NICU were mother's age over 35 years, low level of education, second/more gestation, weight under 2500 g, Apgar score under 7, premature rupture of membranes, macrosomia and mother's infectious pathology. Accurate identification of risk factors and anticipation at the birth of a high-risk neonate would result in adequate preparation and prompt resuscitation of neonates who need some level of intervention and thus, reducing neonatal morbidity and mortality.

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“…Escherichia coli have high rates of resistance to fluoroquinolones, Klebsiella pneumoniae to the third generation of cephalosporins and carbapenems, and a percentage of invasive isolates resistant to methicillin (MRSA) and vancomycin-resistant Enterococcus faecium above European average [9]. After genetic diseases, pediatric infectious pathology is common, the prescription of antibiotics is much more common, and the approach to these infections is similar to that of adults [11,12]. Viral etiology is often found in children and in some types of pathologies, which is why the administration of antibiotics is useless and contraindicated.…”

Section: Introductionmentioning

confidence: 99%

Aetiology of Bacterial Infections and Antibiotic Resistance in Pediatric Patients from a Romanian Hospital

Păduraru¹,

Jurcă²,

Zaha³

et al. 2022

Pharmacophore

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The development of microorganism resistance to antibiotics is a topic of global interest and Romania is among the most vulnerable countries in terms of antimicrobial resistance. Our retrospective study was carried out for a year at the Emergency Clinical Hospital for Children "Saint John" in Galati, on a number of 9910 pathological samples. The main isolated strains were Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. A percent of 25.4 was methicillin-resistant Staphylococcus aureus infections and strains displayed high rates of resistance to beta-lactams and macrolides. Less effective for the treatment of infections with Escherichia coli were aminopenicillins and cephalosporins although resistance to third-generation cephalosporins had a relatively small value than the national one. Isolated Escherichia coli strains showed low resistance to fluoroquinolones and aminoglycosides also. Klebsiella sp strains showed increased resistance to third-generation cephalosporins, fluoroquinolones, and aminoglycosides higher than the values recorded at the European level. Results obtained in terms of antibiotic resistance are lower than those recorded in some studies at a national level but higher than the European average. The situation remains worrying if we consider the fact that the selected group is a pediatric one, with most children under nine years. More than ever, we must take active measures in perspective about the seriousness of the problem and the long-term consequences.

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Pattern of Newborn Antibiotic Use in a Tertiary Level Maternity for Five Years

Cited by 8 publications

References 31 publications

Genetic evidence for a causal link between gut microbiota and arterial embolism and thrombosis: a two-sample Mendelian randomization study

Genetic evidence for a causal link between gut microbiota and arterial embolism and thrombosis: a two-sample Mendelian randomization study

Retrospective Study on the Risk Factors for Resuscitation at Birth and Admission to the NICU in a Third Level Maternity

Aetiology of Bacterial Infections and Antibiotic Resistance in Pediatric Patients from a Romanian Hospital

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