Pattern of occurrence of obsessive-compulsive symptoms in bipolar disorder

Tonna, Matteo; Trinchieri, Margherita; Lucarini, Valeria; Ferrari, Matteo; Ballerini, Massimo; Ossola, Paolo; Panfilis, Chiara De; Marchesi, Carlo

doi:10.1016/j.psychres.2021.113715

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…However, the Y-BOCS-11 sub-scale was linked to reduced insight into obsessive-compulsive symptoms among patients with comorbidity [ 74 , 76 ]. Notably, in individuals with BD, the co-occurrence of OCD was more likely to manifest during mixed manic for a few studies [ 64 , 77 ], mixed state in one case [ 101 ], and depressive episodes for many others [ 41 , 51 , 62 , 101 ]. Several types of obsessions were found to be positively associated with BD-OCD comorbidity, including sexual [ 75 , 81 , 82 , 92 ], symmetry [ 57 , 59 , 102 ], aggressive [ 59 , 92 ], religious [ 81 , 92 ], contamination [ 59 , 62 , 64 , 92 ], forbidden thoughts [ 40 ], saving [ 110 ], and hoarding obsessions [ 57 , 75 , 113 , 115 , 116 ].…”

Section: Resultsmentioning

confidence: 99%

“…The other studies selected did not identify a single treatment modality. Overall, most authors have used mood stabilizers [ 67 , 80 , 93 , 101 ], with lithium and valproate being used more frequently [ 35 , 84 , 90 , 113 ]. There has often been the addition of antipsychotics [ 35 , 63 , 64 , 80 , 84 , 101 ], mainly second generation and more frequently olanzapine [ 67 , 84 , 113 ].…”

Section: Resultsmentioning

confidence: 99%

“…Overall, most authors have used mood stabilizers [ 67 , 80 , 93 , 101 ], with lithium and valproate being used more frequently [ 35 , 84 , 90 , 113 ]. There has often been the addition of antipsychotics [ 35 , 63 , 64 , 80 , 84 , 101 ], mainly second generation and more frequently olanzapine [ 67 , 84 , 113 ]. The role of olanzapine is particularly relevant in the BD-OCD comorbidity, since an analysis of data derived from three identically designed open-label trials focusing on olanzapine treatment in youth with BD, conducted in the USA, revealed that the treatment response in individuals with OCD-BD comorbidity was notably lower than that in patients without this comorbidity.…”

Section: Resultsmentioning

confidence: 99%

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Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

de Filippis,

Aguglia,

Costanza

et al. 2024

JCM

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Background: Bipolar disorder (BD) and obsessive–compulsive disorder (OCD) comorbidity is an emerging condition in psychiatry, with relevant nosological, clinical, and therapeutic implications. Methods: We updated our previous systematic review on epidemiology and standard diagnostic validators (including phenomenology, course of illness, heredity, biological markers, and treatment response) of BD-OCD. Relevant papers published until (and including) 15 October 2023 were identified by searching the electronic databases MEDLINE, Embase, PsychINFO, and Cochrane Library, according to the PRISMA statement (PROSPERO registration number, CRD42021267685). Results: We identified 38 new articles, which added to the previous 64 and raised the total to 102. The lifetime comorbidity prevalence ranged from 0.26 to 27.8% for BD and from 0.3 to 53.3% for OCD. The onset of the two disorders appears to be often overlapping, although the appearance of the primary disorder may influence the outcome. Compared to a single diagnosis, BD-OCD exhibited a distinct pattern of OC symptoms typically following an episodic course, occurring in up to 75% of cases (vs. 3%). Notably, these OC symptoms tended to worsen during depressive episodes (78%) and improve during manic or hypomanic episodes (64%). Similarly, a BD course appears to be chronic in individuals with BD-OCD in comparison to patients without. Additionally, individuals with BD-OCD comorbidity experienced more depressive episodes (mean of 8.9 ± 4.2) compared to those without comorbidity (mean of 4.1 ± 2.7). Conclusions: We found a greater likelihood of antidepressant-induced manic/hypomanic episodes (60% vs. 4.1%), and mood stabilizers with antipsychotic add-ons emerging as a preferred treatment. In line with our previous work, BD-OCD comorbidity encompasses a condition of greater nosological and clinical complexity than individual disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

de Filippis,

Aguglia,

Costanza

et al. 2024

JCM

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“…Moreover, its use in the clinical setting, before the clinical interview could allow the clinician to have a general assessment of the symptomatologic profile of the subject and consent a faster and deeper investigation on some relevant symptomatologic domains. In this framework, it should be noted that, besides SAD, OC features have been also reported in a wide range of psychiatric conditions, ranging from neurodevelopmental disorders, to mood disorders, feeding and eating disorders and personality disorders, often worsening the clinical picture and response to treatments (McKay et al, 2000;Mukai et al, 2011;Postorino et al, 2017;Pazuniak and Pekrul, 2020;Tonna et al, 2021;Amianto et al, 2022;Reilly et al, 2022).…”

Section: Discussionmentioning

confidence: 98%

“…Despite the majority clinical researches on OCD have focused on the full-blown condition (Grant et al, 2012), the literature is stressing how, like many other psychiatric disorders, OCD can also occur in a milder subsyndromal form: in light of a dimensional approach to psychopathology, subthreshold obsessive-compulsive (OC) traits can be found continuously distributed in the general population (Chamberlain et al, 2005;Grant and Chamberlain, 2019). In addition, OC traits have been observed in clinical population of patients with different psychiatric conditions, such as autism spectrum disorder (Postorino et al, 2017;Pazuniak and Pekrul, 2020), mood disorders (Tonna et al, 2021), feeding and eating disorders (Amianto et al, 2022;Reilly et al, 2022), personality disorders (McKay et al, 2000) and even catatonic manifestations (Mukai et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Validation of the short version of the obsessive compulsive spectrum questionnaire

et al. 2023

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AimIn the recent years, a rising amount of research has stressed the importance of a dimensional perspective on mental disorders. In particular, the conceptualization of an obsessive–compulsive spectrum appears to be in line with the very first descriptions of Obsessive–Compulsive Disorder and has been partially acknowledged by the inclusion of the “OCD-spectrum related syndromes and disorders” section in the DSM-5. The goal of the current study is to ascertain the psychometric characteristics of the Obsessive–Compulsive Spectrum–Short Version (OBS-SV), a novel questionnaire designed to measure the complete range of obsessive–compulsive symptoms, from severe full blown to subthreshold ones.MethodsForty three subjects with a clinical diagnosis of OCD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 42 subjects with a clinical diagnosis of social anxiety disorder (SAD), and 60 individuals without current or lifetime mental disorders (HC) were recruited from the Psychiatric Clinic of the University of Pisa. Subjects were assessed with the SCID-5, the Yale Brown Obsessive Compulsive Scale (Y-BOCS) and the OBS-SV.ResultsOBS-SV showed strong test–retest reliability for both the total and the domains scores, as well as a high level of internal consistency. The Pearson’s coefficients for the OBS-SV domain scores ranged from 0.771 to 0.943, and they were positively and strongly linked with one another (p < 0.001). The OBS-SV total score had a strong correlation with each of the OBS-SV domain scores. All correlation coefficients between OBS-SV and additional measures of OCS were observed to be strong, significant and positive. Both OBS-SV domain and overall score differences between diagnostic groups were found to be statistically significant. From HCs, to the SAD, up to the OC group, which had the highest values, the OBS-SV total score grew dramatically and progressively.ConclusionThe OBS-SV demonstrated significant convergent validity with other dimensional OCD measures, excellent internal consistency, and test–retest reliability. Across the three diagnostic categories, the questionnaire functioned differently, with a rising score gradient from healthy controls through SAD patients to OCD subjects.

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Rate of OCD and sub-threshold OCD in bipolar disorder patients with first depressive episode

Braverman

Fuchs

Weizman

et al. 2021

Psychiatry Research

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Pattern of occurrence of obsessive-compulsive symptoms in bipolar disorder

Cited by 4 publications

References 33 publications

Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

Validation of the short version of the obsessive compulsive spectrum questionnaire

Rate of OCD and sub-threshold OCD in bipolar disorder patients with first depressive episode

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