Pattern of Pharmacotherapy and Assessment of Drug Related Problems in Ischemic Heart Disease Patients

Abstract

Aim: To study the prescribing patterns of drugs used in Ischemic Heart Disease (IHD) patients and to identify Drug Related Problems (DRPs) associated with treatment. Methodology: 120 patients from the cardiology inpatient department who were suffering from IHD were included in this prospective, observational and analytical study conducted in Sagar hospitals, Kumaraswamy layout, Bengaluru, India. Results: Out of a total of 120 patients, 76 (61.67%) were males and 46 (38.33%) were females. Subjects of age group 61-70 (25.0%) were found to be more susceptible to IHD. Most of the prescriptions were prescribed with Lipid lowering agents (12.16%), followed by β-blockers (11.10%), Anti-Platelets (8.72%). A total of 221 DRPs were identified. Drug interactions (41.63%) were the most common drug related problems observed, followed by Untreated indications (25.79%), Medication use without indication (9.05%), Adverse Drug Reactions (ADRs) (9.05%), Overdose (6.79%), Sub-therapeutic dose (3.17%). The most common drug-drug interaction was Clopidogrel+Aspirin (6.52%), followed by Furosemide+Aspirin (6.52%) and Atorvastatin+Clopidogrel (5.43%). The most offending drug involved in the drug-drug interactions was observed to be Aspirin. Conclusion: Our study suggests that Statins, Anti-Platelet and Anti-Anginal/Ischemic drugs are major cardiovascular drugs used in the treatment of IHD. The various DRPs were observed to be due to polypharmacy practiced in the treatment of IHD which emphasizes the importance of early detection, evaluation and documentation of DRPs for better patient care and quality of life of patients with IHD.

Prevalence and factors associated with adverse drug reactions among heart failure patients hospitalized at Mbarara Regional Referral Hospital, Uganda

“…GI system was the most frequently (27.5%) affected system by ADRs, followed by the nervous system (19.5%), Endocrine & metabolic systems (18.3%). These results are in line with previous findings that had shown the GI system as the commonly affected system among hospitalized HF patients [ 38 , 39 , 42 ].…”

Prevalence of Risk Elements, Severity Assessment and Treatment Outcomes of Stroke – A Prospective Observational Study

“…According to World Health Organization, stroke is defined as a group of disorders of brain and blood vessels that develops rapidly with the clinical signs and the disturbances of the cerebral function lasting for 24 hours or longer leading to death, which occurs with a vascular origin [1]. Out of these 5 million people die and another 5 million are permanently disabled.…”

Test

“…CVDs are caused by high blood pressure, smoking, diabetes, lack of exercise, obesity, poor diet, high blood cholesterol, and excessive alcohol consumption [2]. Coronary heart disease (CHD), also known as Coronary artery disease (CAD) or Ischemic heart disease (IHD), is a condition in which atheroma (degeneration of arterial walls) blocks blood low to the heart [3].…”

“…Because of an increase in the sale of new pharmaceuticals and delayed ADRs, as well as the cost of drugs, prescription capacity, and variation in prescribing and drug consumption, prescription pattern monitoring studies are becoming increasingly important. The goal of this study is to improve the population's rational/safe drug use [3,13].…”

“…The study emphasises the importance of examining DRPs for better patient care and overall quality of life [3]. Prescription patterns should be investigated in order to verify that patients receive reasonable pharmacotherapy and high-quality medical care, and the prescribing pattern can be improved by reducing the number of pills per prescription [14].…”