Pattern of Presentation and Survival of Breast Cancer in a Teaching Hospital in North Western Nigeria

Kene, Terfa S.; Odigie, Vincent I; Yusufu, Lazarus Md; Yusuf, Bidemi; Shehu, S M; Kase, John T.

doi:10.5001/omj.2010.29

Cited by 54 publications

(66 citation statements)

References 13 publications

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“…Our finding is in agreement with the study carried in Zaria [32]). The reason for this observation may be due to the fact that the Hausa and Fulani are the major ethnic groups in Sokoto, North Western Nigeria.…”

Section: Discussionsupporting

confidence: 94%

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Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

Osaro¹,

Me²,

Michael³

et al. 2018

J Pregnancy Reprod

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Breast cancer is the most common female malignancy both in Nigeria and globally. The aim of this case-control study was to determine the changes in some haematological parameters among breast cancer patients in Sokoto, Nigeria. The study included a total of 46 breast cancer subjects (mean age 42.91 ± 5.83 years) visiting the Specialist Hospital, in Sokoto, North Western Nigeria. A total of 46 apparently healthy age-matched women were monitored as control. Some haematological (packed cell volume, total white blood cell count and platelet count) were analyzed using the auto-haematology analyzer (Genesis, HA6000). Breast cancer staging was determined using the TNM classification. Data were analyzed using SPSS 22.0 statistical package. A p-value ≤0.05 was considered significant in all comparisons. The result indicated that patients with breast cancer had a lower mean packed cell volume (29.20 ± 0.50 %) compared to controls (36.20 ± 0.42 %) (p=0.000). The mean total white blood cell count of patients was also statistically lower among breast cancer patients (3.91 ± 0.19×10 9 /l) compared to controls (4.38 ± 0.13×10 9 /l) (p=0.045). There were no statistically significant differences in the mean value of platelet counts of breast cancer patients (197 ± 5.06×10 9 /l) and controls (207 ± 5.84×10 9 /l) (p=0.217). Newly diagnosed patients who were not on therapy had significantly lower mean values of PCV compared to controls (p<0.05). There were no statistically significant differences in the mean values of total white blood cell counts and platelets count of newly diagnosed patients that are not on therapy and controls (p>0.05). The mean PCV levels were significant lower as compared to controls (p<0.05) Patients that were on chemotherapy had significantly lower values of PCV, total white cell counts and platelets compared to patients who were not yet on any therapy (p <0.05). There were no statistically significant differences in the PCV, total white blood cell counts and platelets based on the different stages of breast cancer (p >0.05). Findings of this study have shown that breast cancer patients had a lower PCV and TWBC count compared to controls. Chemotherapy further exerts adverse effects on patients as seen with the significantly decreased values of haematological parameters on patients on therapy. Findings of this study also shows that breast cancer patients have low PCV and WBC count compared to controls. Haematological investigation should be taken as an essential tool in the investigation and management of breast cancer. Active breast cancer awareness campaign should be carried out on the need for early diagnosis. More research should be carried out to investigate the pattern of other haematological parameters in breast cancer disease.

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Section: Discussionsupporting

confidence: 94%

“…Our finding is in agreement with the study carried out in Zaria [32] which indicated that half of their breast cancer patients presented with stage 3 diseases.…”

Section: Discussionsupporting

confidence: 93%

Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

Osaro¹,

Me²,

Michael³

et al. 2018

J Pregnancy Reprod

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“…10 The incidence of malignant growth amongst the breast lesions is fairly common with more number of cases being detected in recent years and so it warrants the need for detecting out the morbid pattern of the tumour. Breast cancer kills 376000 women a year worldwide and there are about 900000 new case annually with increasing incidence in most parts of the world and especially developing country where it is almost as common as cervical cancer, the leading female cancer in developing world.…”

Section: Discussionmentioning

confidence: 99%

A clinico-pathological study of malignant breast lump in a tertiary care hospital in Kosi region of Bihar, India

et al. 2016

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“…For example, a retrospective study was performed at Ahmadu Bello University Teaching Hospital in Nigeria, a country in which approximately 49% of the population is younger than 15 years of age 12 . In this study, the average age of participants with breast cancer was 44.5 years, the majority (57.4%) was between 30 and 49 years of age, and 62% of the women were premenopausal 13 . Ghiasvand, et al 14 carried out a hospital-based case-control study that included 521 women with histologically confirmed breast cancer and 521 controls matched by age and place of residence.…”

Section: Risk Factorsmentioning

confidence: 99%

The Epidemiological Challenges of Breast Cancer among Premenopausal Women in Limited Resource Settings

Torres-Mejı́a

Navarro

Tuesca-Molina

et al. 2017

RIC

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Breast cancer is the most common malignant tumor among women of reproductive age and is also the most costly according to European reports. In this context, the aim of the present review is to identify factors that make breast cancer in premenopausal women an epidemiological challenge in developing countries. Epidemiological aspects of breast cancer, including risk factors, early detection methods, and treatment, are addressed. Breast cancer in premenopausal women should be included in the political and strategic agendas in developing countries to direct the necessary resources for prevention, detection, and control. (REV INVES CLIN. 2017;69:59-65)

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Pattern of Presentation and Survival of Breast Cancer in a Teaching Hospital in North Western Nigeria

Abstract: The overall survival rate was low and patients with early breast cancer had better survival than those with advanced disease. Majority of the patients were young premenopausal women with advanced breast cancer.

Cited by 54 publications

References 13 publications

Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

A clinico-pathological study of malignant breast lump in a tertiary care hospital in Kosi region of Bihar, India

The Epidemiological Challenges of Breast Cancer among Premenopausal Women in Limited Resource Settings

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