Pattern of Primary Gastrointestinal Tract Malignancy Among Saudi Nationals: A Retrospective Study

Al-Mofarreh, Mohammed; Afzal, Mohammed; Al-Kraida, Abdullah A.; Al-Qasabi, Qasim O.; Fakunle, Y.M.; Quasem, Syed M. Abul; Baez-Giangreco, Atilio

doi:10.5144/0256-4947.1991.15

Cited by 7 publications

(19 citation statements)

References 12 publications

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“…Several reports from various provinces of the Kingdom of Saudi Arabia studying the pattern of alimentary tract cancer, have been documented in the medical literature during the last few years [7][8][9][10]. Our current report is the first to describe this pattern in the Southern Province of the Kingdom.…”

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Pattern of Primary Gastrointestinal Tract Cancer in the Southern Province

Morad

Khan²,

Al-Saigh³

et al. 1992

Ann Saudi Med

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Two hundred thirty-four cases of primary gastrointestinal tract malignancy were diagnosed at the histopathology laboratory of Asir Central Hospital over a four-year period, from 1987 to 1990. The current study is a retrospective analysis of these cases regarding rank orders, distribution according to nationality, age and sex, primary sites affected and the histopathologic pattern. Eighty-eight percent of our cases were Saudi and 12% were non-Saudi nationals. The mean age of patients was 60 ± 16 years with a male:female ratio of 2:1. Primary liver cancer was the most common malignancy (29%), followed by gastric cancer (27%), colorectal cancer (21%) and esophageal cancer (13%). Comparison of our findings to those from other provinces of the Kingdom are also included.

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confidence: 66%

“…Patterns of primary gastrointestinal tract malignancy in five studies from three provinces of the Kingdom of Saudi Arabia are summarized in Table 5 [7][8][9][10]. All five studies agree that the colorectal segment is not the most common site of origin of primary gastrointestinal tract cancer in Saudi Arabia.…”

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confidence: 94%

Pattern of Primary Gastrointestinal Tract Cancer in the Southern Province

Morad

Khan²,

Al-Saigh³

et al. 1992

Ann Saudi Med

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“…[7][8][9] Only a few reports have been devoted to the study of the pattern of gastric cancer. 10 The current study describes the general pattern of primary gastric cancer in Southern Saudi Arabia for the first time.…”

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Gastric Cancer in Southern Saudi Arabia

Hamdi

Morad

1994

Annals of Saudi Medicine

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A total of 84 cases of primary gastric cancer were diagnosed in the histopathology laboratory of Asir Central Hospital over a five year period (1987 to 1991). Seventy-two patients (86%) were Saudis and 12 cases (14%) were non-Saudis. The mean age of the patients included in this study was 60 years with a range of 22 to 85 years and a male:female ratio of 4.6:1. Intestinal adenocarcinoma occurred in 63 patients (75%) followed by malignant lymphomas in 12 cases (14%) and diffuse adenocarcinoma in nine cases (11%). The gastric antrum was the most common site affected (47%), followed by gastric corpus (27%), cardia (14%), and fundus (12%). Comparisons of our findings to similar reports from other provinces of Saudi Arabia and other countries are discussed.

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“…In another study, gastric carcinoma represented 31% of gastrointestinal malignancies. 23 A pattern of gradually increasing age of the diagnosis of gastric carcinoma is typically the result of a change in the age of acquisition of H. pylori infection in a population.Although the epidemiology evidence linking gastric carcinoma and H. pylori is now quite strong, 1,24-39 can we use that information to reduce the risk of gastric carcinoma? The risk of developing gastric cancer increases with the severity of gastritis and is highest with the most advanced stages.…”

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confidence: 99%

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It Should Be Possible to Eliminate Peptic Ulcer Disease and Gastric Carcinoma from Saudi Arabia

Graham

Shabib

Al-Mofleh

1994

Annals of Saudi Medicine

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Until recently, it would have been unthinkable to suggest that it might be possible to eliminate peptic ulcers and gastric carcinoma from the Kingdom of Saudi Arabia. This possibility now deserves serious consideration. This change in thinking is a direct result of recent studies linking the seemingly different diseases to an infection with a bacterium, Helicobacter pylori. H. pylori infection has been linked to gastric carcinoma, peptic ulcer disease, and gastric B-cell lymphoma.1-5 The tremendous morbidity and mortality from H. pylori infection are only now becoming appreciated. The cumulative risk of developing a peptic ulcer is 15% to 20% and 0.5% to 1% risk of developing gastric carcinoma. The risk of gastric lymphoma is unknown. Overall, the recognized rate of mortality or morbidity related to H. pylori infection is 20% to 30% of those infected.It has long been appreciated that chronic atrophic gastritis was a precursor lesion to gastric carcinoma and that, in areas of the world where atrophic gastritis was common in young adults, gastric cancer was frequent. Gastritis was also known to be almost universally present in patients with gastric or duodenal ulcer disease. 2,6,7 Studies of the epidemiology of these gastritis-associated diseases demonstrated that unidentified environmental factor(s) were involved in development of gastritis and in progression from atrophic gastritis to gastric cancer. Despite a large number of studies and clues such as differences in prevalence of gastritis depending on socioeconomic class, ethnic group, age, implicating environmental factors, no common theme or factor emerged until approximately 10 years ago when H. pylori was cultured from the gastric mucosa of patients with gastritis and ulcer disease. It was subsequently shown that ingestion of H. pylori resulted in gastritis and that gastritis improved and even actually reversed following eradication of the infection. [8][9][10] Over the last decade, H. pylori has become established as the major cause of gastritis in humans. Recently, a number of investigators have conclusively demonstrated that eradication of the H. pylori infection effectively cures peptic ulcer disease. [11][12][13][14][15][16][17][18][19][20] In this instance, "cure" means that the natural history of ulcer disease changes, as ulcers do not recur. Thus, no H. pylori, no ulcer. 7H. pylori, gastritis, and gastric carcinoma: The latent period between development of atrophic gastritis and gastric carcinoma is measured in decades, whereas the latent period for peptic ulcer is shorter. 21 It follows that the spectrum of H. pylori-related disease present in a population reflects the average age of acquisition of the infection. 1,22 In developing countries, the majority of individuals acquire H. pylori infection in early childhood and, as a result, atrophic gastritis is common in mid-life. In developed countries, gastric carcinoma is typically a disease of the elderly and reflects the fact that this group represents those who developed H. pylori infection in chil...

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Pattern of Primary Gastrointestinal Tract Malignancy Among Saudi Nationals: A Retrospective Study

Cited by 7 publications

References 12 publications

Pattern of Primary Gastrointestinal Tract Cancer in the Southern Province

Pattern of Primary Gastrointestinal Tract Cancer in the Southern Province

Gastric Cancer in Southern Saudi Arabia

It Should Be Possible to Eliminate Peptic Ulcer Disease and Gastric Carcinoma from Saudi Arabia

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