Pattern of Renal Cell Carcinoma – A Single Center Experience in Nepal.

Abstract

Background Renal tumor is the 13th most common malignancy in the world and more than 90% of renal tumors are renal cell carcinomas. As there is no data available on renal cell carcinoma in Nepal, hence this study was undertaken to analyze the patterns of renal cell carcinoma in patients with renal mass at a tertiary level hospital in Nepal. Objectives To analyze the patterns of renal cell carcinoma in patients with renal mass at a tertiary level hospital in Nepal. Methods The case records of 50 consecutive patients with renal cell carcinoma presenting at the Tribhuvan University Teaching Hospital, Kathmandu from July 2006 to June 2011 were retrospectively evaluated for presenting symptoms, physical finding, investigation and histopathology report. Results Out of 50 patients, 64% were male and 36% were female. The age ranged between 11 to 78 years (mean ± SD: 55 ± 15 years). Fifty four percent of patients were smokers. Incidentally tumor was detected in 40% cases by ultrasonography and the typical triad was present in only 4%. The tumor was occupying upper pole in 40% of cases. The tumor size ranged from 3 to 15 cm (mean ± SD: 7.3 ± 2.9 cm). Histopathologically, 76% of the patient had organ confined renal cell carcinoma (T1-2 N0 M0). Clear cell was the most common type seen in 86%. Fuhrman’s nuclear grade 2 was found in 50%. ConclusionMany of the renal cell carcinoma are detected incidentally, at an early stage and are of clear cell subtype.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6302 Kathmandu Univ Med J 2011;9(3):185-8

Clinicopathological study of adult malignant renal tumours in Kashmir

“…Renal cell carcinoma usually presents with a classical triad of flank pain, hematuria and abdominal lump. In our study, classical triad was noted in 11.11% cases which was slightly higher than 4% as observed by Siddharth et al [24] and similar to 10.67% observed by Anitha Padmanabhan et al [25].In our study majority 31.11% cases of renal cell carcinoma were diagnosed incidentally. The incidence of incidental RCC ranged from 15 to 61% and recently reported to be as high as 72.7% from South korea.…”

Incidence, clinical evaluation and surgical treatment of patients with renal cell cancer: 40-years of experience in the University Hospital Rijeka

“…Razlog tome je sve veći broj paciprosječne dobi s 57 godina (period 1982. -1983 11,12 . Prosječna dob naših pacijenata bila je 63 godine te je time bliža europskim rezultatima.…”

“…pokazali porast incidentalno otkrivenog KB-a od 33,8 % na 72 % između 1985. i 2010. godine 11 . S druge strane postoje i slabije razvijene zemlje poput Nepala u kojih se čak i u današnje vrijeme 60 % pacijenata otkriva zbog simptoma, a samo 40 % incidentalno na ultrazvučnom pregledu 12 . Dijagnostička obrada se tijekom godina mijenjala.…”

“…Najčešći histološki podtip je bio svjetlostanični tip (77 %). I u drugim studijama on se kreće od 90 do 74 % 11,12,27 . Određivanje histološkog podtipa je bitno jer prognoza pacijenata s KB-om djelomično ovisi i o podtipu tumora.…”

“…Ujedno, ciljana terapija koja se koristi kod metastatskog KB-a također ovisi o histološkom podtipu tumora. Fuhrman stupanj II bio je najčešće pronađen, što je podudarno s drugim studijama 12,14,27 . Ova studija je retrospektivna i predstavlja iskustvo jednoga centra te je samim time i limitirana.…”