Pattern of renal diseases observed in native renal biopsies in adults in a single centre in Pakistan

Mubarak, Muhammed; Kazi, Javed Iqbal; Naqvi, Rubina; Ahmed, Ejaz; Akhter, Fazal; Naqvi, Syeda Uzma; Rizvi, Syed Adib-ul-Hasan

doi:10.1111/j.1440-1797.2010.01410.x

Cited by 54 publications

(78 citation statements)

References 9 publications

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“…The most common indication for renal biopsy in our patients was NS in total (40.3%) and also in men (42.6%), while in women it was AUA (38.8%). In most registry and database reports, NS was also the most common indication [6,8,14,18,19,25], while in Italy [2] and in Belgium [20] it was AUA. As we stated earlier, this depends on the biopsy policy of different country or region, but also on availability of the biopsy and socio-economic status.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, data from local or limited national registries of renal biopsy have been reported from South Korea [10,11], Bahrain [12,13], Brazil [14], Romania [15], China [16], Finland [17], Serbia [18], Pakistan [19] and Belgium [20]. Finally, there are also reports that include epidemiological data only on glomerular diseases from Australia [21], Macedonia [22], France [23], USA [24], Iran [25], Germany [26], Lebanon [27], Peru [28] and Poland [29].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

et al. 2013

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PURPOSE: There is a paucity of epidemiological data on biopsy-proven renal disease in Croatia. The purpose of this report is a review of clinical and histological data, over a period of 15 years, from the single biggest adult native renal biopsy centre in Croatia.METHODS: This report includes data from 922 adult native renal biopsies in patients referred from the whole country and performed in our centre from 1996 till February 2012. Data on age, gender, serum creatinine, urine sediment, 24-hour proteinuria, clinical syndrome and histological diagnosis were collected and analyzed retrospectively. In all patients light, immunofluorescence and electron microscopic analysis was performed.RESULTS: The median age of the patients was 48 years (interquartile range 36-59 years), and the majority of patients were men (57.8%). The most common indication for renal biopsy was nephrotic syndrome (40.3%) followed by asymptomatic urinary abnormalities (31.7%). The most common biopsy-proven renal disease in total was IgA glomerulonephritis (19.3%), followed by FSGS (15.8%) and membranous glomerulonephritis (9.2%). In men similar results were found, while in women the most common were hereditary nephritis (13.4%), FSGS (12.9%) and connective tissue disease-related glomerular disorders (11.6%).CONCLUSION: The presented data are an important contribution to the better understanding of the epidemiology of biopsy-proven renal disease in Croatia and Europe throughout comparison with other registry data. This data should be the basis for the formation of Croatian Registry of Renal Biopsies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

et al. 2013

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“…This would be true in Asian countries like China, Indonesia , Malaysia,Thailand and Singapore which have a high prevalence of MesPGN. 24,[26][27][28][29] In some countries like Malaysia and Singapore the prevalence of MesPGN is already decreasing in keeping the urbanization and better housing and other amenities in these countries. 24,28 Bangladesh is a rising country in context of urbanization and other field of developments, i.e, this hypothesis can explain the majority of MPGN as well as MesPGN in our study.…”

Section: Discussionmentioning

confidence: 99%

A Two Year Observation on Trend of Primary Glomerulonephritis in A Tertiary Care Hospital of Bangladesh

et al. 2016

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“…IgM-нефрит встречается реже -2-5% общего числа всех случаев ГН [11,12], а в общей популяции -около 0,3 случая на 1 млн населения [12].…”

Section: казанский медицинский журнал 2017 г том 98 №5unclassified

Modern classification, progression factors, treatment and outcomes of primary mesangial proliferative glomerulonephritis

et al. 2017

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The choice of treatment of mesangial proliferative glomerulonephritis (post-infection, immunoglobulin A, G and M nephritis) is performed taking into account the remission achievement, slowing of progression and reduction of the risk of recurrences of glomerulonephritis. The efficiency of etiologic factor removing is debatable: glomerulonephritis associated with infections usually resolves after their elimination; individual patients achieve immunoglobulin A nephritis remission with persistent antimicrobial treatment of focal infection, but surgical removal of the focus (tonsillectomy) does not affect the long-term prognosis, therefore it is not recommended. Treatment of immunoglobulin A nephritis with oral prednisone for up to 4 months, sometimes in combination with cyclophosphamide (cyclophosphane), reduces the likelihood of its relapse. At low risk of progression of immunoglobulin A nephritis with proteinuria less than 1 g/day, long-term therapy with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers is indicated with administration of maximum tolerated doses for proteinuria more than 1 g/day. Also fish oil 3 g/day is administered for up to 2 years. If proteinuria more than 1 g/day persists for 3-6 months, corticosteroids are recommended for 6 months. With mild renal dysfunction, corticosteroids are prescribed orally or in pulse-therapy with high doses intravenously and maintenance therapy with low doses orally. Immunosuppressive therapy - cyclophosphamide, cyclosporine, azathioprine, mycophenolate mofetil - in combination with corticosteroids is indicated in rapid loss of renal function or massive/moderate proteinuria. In minimal proteinuria immunosuppressive therapy is considered to be unreasonable. Use of intravenous immunoglobulin for immunoglobulin A nephritis from the point of view of lesser toxic effect is possible only as the induction therapy. Currently, there are no clinical recommendations for the treatment of immunoglobulin M nephritis, in case of nephrotic syndrome, corticosteroids are the drugs of the 1st line. There are isolated studies of the use of cyclophosphamide, mycophenolate mofetil, and cyclosporine, with the achievement of remission in frequent relapses of nephrotic syndrome or steroid drug resistance. The cases of immunoglobulin M nephritis treates with retuximab with a positive effect are described. The effectiveness of immunoglobulin G nephritis treatment is less studied, the choice of treatment is similar to that of immunoglobulin A and M nephritis.

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Pattern of renal diseases observed in native renal biopsies in adults in a single centre in Pakistan

Abstract: The pattern of biopsied renal pathology is similar to that reported recently from other parts of the world with similar biopsy indications.

Cited by 54 publications

References 9 publications

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

A Two Year Observation on Trend of Primary Glomerulonephritis in A Tertiary Care Hospital of Bangladesh

Modern classification, progression factors, treatment and outcomes of primary mesangial proliferative glomerulonephritis

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