Pattern of Serum Electrolytes Imbalance among Patients with Acute Exacerbation of COPD Admitted in a Tertiary Level Hospital

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease and there is not yet a cure. Not only in Bangladesh but also worldwide the incidence of COPD is increasing. The disease is associated with some metabolic derangement such as electrolytes imbalance. Those factors further worsen the disease course. As a result COPD related morbidity, mortality and cost to health systems are also increasing. This cross-sectional observational study was conducted in Faridpur Medical College Hospital (FMCH) over 6 months among 100 patients who were admitted with acute exacerbation of COPD. The mean age was (58.13 ± 9.96) years. In this study serum electrolytes were found below the normal range in 68 (68%) cases and within normal range in 32(32%) cases. Isolated hyponatremia was observed in 36(53%) and 15(22%) had isolated hypokalaemia. Both hyponatremia and hypokalaemia was found in 17(25%) cases. The mean serum sodium level was (133.82±2.52) mmol/l. Among patients with isolated hyponatremia, 24(67%) had mild hyponatremia and 12(33%) got moderate hyponatremia. Again the mean serum potassium was (3.45±0.23) mmol/l. Among patients with isolated hypokalaemia, 10(67%) had mild hypokalaemia and 5(33%) had moderate hypokalaemia. Both hyponatremia and hypokalaemia was observed in one fourth of total electrolytes depleted cases and all were within the mild range. No patient had severe hyponatremia or hypokalaemia.
 Faridpur Med. Coll. J. Jan 2020;15(1): 24-27

Electrolyte disturbances in a sample of hospitalized patients from Iraq

“…The most likely explanations for the present data are using beta 2-adrenoceptor agonists and theophylline as the most common treatment in stable COPD. Unfortunately, these classes of treatments can induce electrolyte imbalance in respiratory issues and COPD patients [ 11 ]. Many factors might be responsible for producing electrolyte imbalances in COPD patients.…”

Hyponatremia is an independent predictor of emergency department revisits in acute exacerbation of COPD

“…8 The rate of hyponatremia in AECOPD varies between 10.8% 12 and 36%. 24 The classification of hyponatremia is reported as mostly mild and moderate. 13,24 In parallel to the literature, the rates of hyponatremia in home-manageable AECOPD was 22% in our study and most of these patients were classified as mild.…”

“…24 The classification of hyponatremia is reported as mostly mild and moderate. 13,24 In parallel to the literature, the rates of hyponatremia in home-manageable AECOPD was 22% in our study and most of these patients were classified as mild. Several parameters have been described to be related to hyponatremia.…”