Pattern of systemic lupus erythematosus in NIGERIA: a multicentre descriptive hospital-based study

Osaze, Ojo; Olaosebikan, Hakeem Babatunde; Yerima, Abubakar; Uhunmwangho, Courage Ukponmwan; Ima-Edomwonyi, Uyiekpen Emmanuel; Oguntona, Akintayo Segun; Chibuzo, Okwara Celestine; Dedeke, Ibukunoluwa Ayoade; Na’isa, Musa Bello Kofar; Nwankwo, Henry Madu; Agun-Ebreme, Mary; John-Maduagwu, Obiageli Jane; Ekeigwe, Ngozi Lina; Adenitan, Ajibade; Emorinken, Airenakho; Odunlami, Gbenga Joshua; Uchechukwu, Tralagba; Augie, Abdullahi Ibrahim; Abdul’Aziz, Umar; Adelowo, Olufemi

doi:10.1007/s10067-023-06672-y

Cited by 5 publications

(16 citation statements)

References 25 publications

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“…Arthritis was the most common clinical presentation, found in 82.6% of the patients. This is similar to other studies where arthritis was also the most common clinical feature [ 10 – 12 , 16 , 19 ]. This finding is also supported by a systematic review and meta-analysis of SLE in sub-Saharan Africa which showed that rheumatological manifestations were the most common features, ranging from 5.1% to 99.9%.…”

Section: Discussionsupporting

confidence: 92%

“…Renal involvement (proteinuria) was detected in about 37.5% in our study, similar to other studies done in Nigeria, US, Brazil, and Abidjan [ 10 , 12 , 19 , 22 , 25 ], but it was higher in a Malaysian study (58.6%) [ 29 ]. This may be due to the multi-ethnicity of the Malaysian population.…”

Section: Discussionsupporting

confidence: 90%

“…However, a Polish study showed a much longer duration of symptoms (5 years), which may be due to a milder, nonspecific initial course of the disease in the study population [ 20 ]. The mean age at presentation in this study was 33.8 years, similar to other studies [ 10 , 11 , 17 ], and most of them were engaged in productive activities. However, Emorinken et al from south-south Nigeria reported a lower mean age at presentation of 28 years [ 12 ].…”

Section: Discussionsupporting

confidence: 89%

“…Neuropsychiatric manifestation was an important feature, reported in 33.8% of the patients, with a similar finding reported by Osaze et al and also an Ivorian study by Gbané-Koné et al (33.8% and 36.75% respectively) [ 10 , 25 ], but much lower rates were recorded in a comparative study of SLE between Sudanese and Swedish populations (15.6% and 11% respectively) [ 26 ]. Our finding was also higher than in African-American and Brazilian studies (15.7% and 12.1% respectively) but lower than in a Polish study (59.2%) [ 20 , 22 , 27 ].…”

Section: Discussionsupporting

confidence: 83%

“…Synovitis was the most common symptom, accounting for 61% of cases, followed by acute, subacute, and chronic cutaneous lupus accounting for 51%, 19.9%, and 11.4% of cases respectively. Antinuclear antibody (ANA) was positive in 98% of cases, with titres ranging from 1 : 80 to 1 : 64,000 [ 10 ]. It is important to note that this study heralded the Lupus Registry in Nigeria (LURIN) established in 2021 where all data on lupus diagnosed in Nigeria are continuously collated and is one of the very few SLE registries in Africa.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria

Odunlami,

Ajibade,

Omotosho

et al. 2024

Reumatologia

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IntroductionThe aims were to study the sociodemographic characteristics of patients presenting to the clinic and to study the clinical and serological pattern of systemic lupus erythematosus (SLE) in a new rheumatology clinic of a predominantly Yoruba population.Material and methodsThis was a retrospective, cross-sectional study conducted over 7 years (January 2017 – December 2023). Patients who satisfied the 1997 American College of Rheumatology (ACR) and/or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria were enrolled using their medical records. Patients with overlap syndromes and other inflammatory or noninflammatory rheumatic diseases were excluded from the study. Their sociodemographic, clinical, laboratory, and treatment data were retrieved from their medical records and analysed using IBM SPSS version 23.0 software.ResultsA total of 65 patients were diagnosed with SLE with a frequency of 15.8%. The mean age ±SD of the patients at presentation was 33.85 years ±11.01 and the female to male ratio was 9.8 : 1. The median (IQR) duration of symptoms at presentation was 7.0 months (3–24). The common clinical presentations included synovitis (86.2%), acute cutaneous rash (53.8%), oral ulcers (52.3%), nonscarring alopecia (50.8%), and serositis (47.7%). Proteinuria was seen in 37.7% of the patients and the predominant renal histopathological feature was Class IV. Antinuclear antibody was 100% positive with 50.94% of the patients having a titre of 1 : 5,120 and above. Anti- double-stranded deoxyribonucleic acid and anti-Smith antibodies each had 50% prevalence. Dyslipidaemia was found in 76.7% of the patients.ConclusionsThe study’s findings are largely consistent with similar studies done in Africa. Further prospective multi-centred studies are needed to further determine the epidemiological characteristics of the disease in Nigeria with a multi-ethnic population.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria

Odunlami,

Ajibade,

Omotosho

et al. 2024

Reumatologia

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Lupus and other autoimmune diseases: Epidemiology in the population of African ancestry and diagnostic and management challenges in Africa

Essouma,

Noubiap

2024

Journal of Allergy and Clinical Immunology: Global

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Psychiatric manifestations of systemic lupus erythematosus: A brief review with two case-reports

Kassim,

Wordefo,

Berhanu

et al. 2024

SAGE Open Medical Case Reports

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Neuropsychiatric systemic lupus erythematosus is a severe neurological and psychiatric manifestation following systemic lupus erythematosus. Neuropsychiatric systemic lupus erythematosus is a global concern with limited data on its impact on quality of life in Africa. Furthermore, there is a lack of published research on neuropsychiatric systemic lupus erythematosus in Ethiopia. In this article, we present two case reports of Ethiopian patients with systemic lupus erythematosus and neuropsychiatric systemic lupus erythematosus, highlighting the challenges of diagnosing neuropsychiatric systemic lupus erythematosus worldwide. Although the patients were treated with alternative pharmacological agents based on available medications, interdisciplinary collaboration between psychologists, psychiatrists, neurologists, and internists is necessary to decrease the burden of systemic lupus erythematosus patients with neuropsychiatric manifestations. Overall, symptomatic therapy for neuropsychiatric systemic lupus erythematosus in developing countries is a good approach until future evidence-based pharmacotherapy is developed.

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Pattern of systemic lupus erythematosus in NIGERIA: a multicentre descriptive hospital-based study

Cited by 5 publications

References 25 publications

Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria

Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria

Lupus and other autoimmune diseases: Epidemiology in the population of African ancestry and diagnostic and management challenges in Africa

Psychiatric manifestations of systemic lupus erythematosus: A brief review with two case-reports

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