Pattern of vitamin D in patients with chronic obstructive pulmonary diseases and in patients with bronchial asthma

Gouda, Essam; Zidan, Mohamed; Gharraf, Heba Said; Younan, Doreene Nazeih; Mohamed, Samar

doi:10.1016/j.ejcdt.2016.02.005

Cited by 6 publications

(11 citation statements)

References 35 publications

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“…The present study found significantly lower levels of Vitamin D in COPD patients in comparison to healthy controls. In people with COPD, the risk of Vitamin D deficiency is higher than expected and is linked with disease severity which is consistent with previous studies[ 15 16 17 26 27 ]. We found 27% COPD patients were having Vitamin D deficiency and 70% have an insufficient level which shows that hypovitaminosis D, i.e., both deficiency and insufficiency were found in 97% of COPD patients in our study and more in higher stages of severity (Gold 3 and 4).…”

Section: Discussionsupporting

confidence: 92%

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Pandey

Garg

Kant

et al. 2021

Tzu Chi Medical Journal

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Objective: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects. Materials and Methods: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data. Results: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher ( P = 0.0001). Conclusion: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease.

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Section: Discussionsupporting

confidence: 92%

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Pandey

Garg

Kant

et al. 2021

Tzu Chi Medical Journal

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“…A lower serum vitamin D level was demonstrated in the previous similar study conducted in Egypt (11.94±7.66 ng/mL). 10 This may be caused by several factors. In general, the higher prevalence of vitamin D deficiency relates to several issues, such as less vitamin D photosynthesis in response to UVB in individuals with darker skin, use of extensive skin coverage, and scarce exposure to sunlight which has often been described in individuals originating from the https://doi.org/10.2147/IJGM.S333039…”

Section: Discussionmentioning

confidence: 99%

“…Low level vitamin D was shown to be associated with lower FEV1, exacerbation, and severity of disease. [10][11][12] Our study aimed to identify the association between vitamin D levels and FEV1, number of exacerbations and CAT scores in both male and female stable COPD patients in Indonesia. To the best of our knowledge, this is the first study assessing the association of vitamin D with FEV1, number of exacerbations and symptoms based on CAT score in stable COPD patients in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Soeroto¹,

Setiawan²,

Asriputri³

et al. 2021

IJGM

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Purpose: This study aimed to assess the association between vitamin D levels and forced expiratory volume in one second (FEV1), number of exacerbations, and symptoms based on COPD assessment test (CAT) scores in stable COPD patients in Indonesia. Patients and Methods: An observational cross-sectional study was conducted. Subjects were stable COPD patients who were treated at a pulmonary clinic in a tertiary referral hospital in West Java from March to June 2018. Results: Thirty subjects were recruited this study with an average age 62±8 years. The mean vitamin D level was 20.17±8.91 ng/mL. Half of the patients had low vitamin D level (<20ng/ mL) (50%). The mean FEV1 (%) predicted value was 37.2±14. The median exacerbation per year was 1 (0-5) and symptoms based on CAT score was 14 (3-34). No correlation was found between vitamin D levels and FEV1 (%) predicted value (r=0.126, p=0.253). Vitamin D level was inversely correlated with number of exacerbations (r=−0.639, p<0.001) and CAT (r= −0.802, p<0.001). Conclusion: Low level of vitamin D was associated with more frequent exacerbation and higher CAT scores but was not associated with FEV1 (%) predicted.

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“…17 Gouda E et al, in his study from India showed that 56.7% of patients with COPD had mild to moderate degree of vitamin D deficiency and 43.3% patients of COPD had severe deficiency. 18 Tedd H et al, in their study showed overall 62% of patients were found to have low 25(OH)-D titres. 19 Mean value of serum vitamin D decreases as GOLD stages become higher.…”

Section: This Is a Cross Sectional Observational Study Conducted Betwmentioning

confidence: 91%

Prevalence of vitamin D deficiency in chronic obstructive pulmonary disease and it’s correlation with forced expiratory volume in one second: a tertiary care centre study

et al. 2018

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Background: Vitamin D deficiency is common all over the Indian subcontinent, with a prevalence of 70-100% in the general population. Vitamin D deficiency has a role in several diseases of the respiratory system including chronic obstructive pulmonary disease (COPD). Studies have shown that vitamin D deficient COPD patients have lower lung function measured by FEV1. We conducted a study to see prevalence of Vitamin D deficiency in COPD patients and it’s correlation with Forced Expiratory Volume in 1 second.Methods: A cross sectional observational study was performed in a tertiary care hospital in Hyderabad, Telangana during the period of one and half year. This included 104 COPD cases attending outpatient department of pulmonary medicine. Serum vitamin D levels were measured, and spirometry was done in all patients and data was analyzed accordingly.Results: Among 104 patients, 87 were males and 17 were females. Most of the study population (44.2%) was aged between 60-70 years. Mean BMI was 26.40 (±5.77) kg/m2. Majority of study populations (66.34%) were in GOLD stage 1 and 2. The mean Vitamin D value of the study population was 20.77±11.74ng/ml. Majority of the COPD patients were vitamin D deficient (69.2%). 25.0 % was severely deficient of vitamin D. The mean FEV1 volume (%) was 83.15±11.53, 60.97±17.47, 30.71±7.96 in sufficient, deficient and severe deficient patients.Conclusions: Vitamin D deficiency is common in COPD patients. Serum vitamin D deficiency increases with increased severity of COPD. There is positive correlation between serum vitamin D levels and post bronchodilator FEV1 (%).

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Pattern of vitamin D in patients with chronic obstructive pulmonary diseases and in patients with bronchial asthma

Cited by 6 publications

References 35 publications

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Prevalence of vitamin D deficiency in chronic obstructive pulmonary disease and it’s correlation with forced expiratory volume in one second: a tertiary care centre study

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