Pattern-Reversal Visual Evoked Potential in Children With Congenital Zika Syndrome

Abstract

Purpose: To objectively evaluate the visual function in children with congenital Zika syndrome using pattern-reversal visual evoked potential (PR-VEP). Methods: This was a cross-sectional study composed of two patient groups: children aged between 18 and 24 months who were positive for the Zika virus (congenital Zika syndrome group) and age-matched healthy children (control group). All patients underwent a comprehensive ophthalmologic examination and PR-VEP was performed binocularly in a room with constant dim illumination. The P100 peak time in the 60' arc stimuli was used, and the results were correlated with visual acuity, cephalic perimeter at birth, and funduscopic findings. Results: Thirty-seven children were included in the congenital Zika syndrome group and 15 in the control group. The mean age was 18.5 ± 0.9 months (range: 17 to 20 months) in the congenital Zika syndrome group and 24.3 ± 1.6 months (range: 21 to 28 months) in the control group. The P100 response was normal in 7 patients (18.9%) with congenital Zika syndrome, borderline in 2 (5.4%), abnormal with prolonged latency in 18 (48.6%), and abnormal with no response in 10 (27.0%). A significant correlation between the visual acuity and P100 peak time was observed ( P < .001). The P100 values were not correlated significantly with the cephalic perimeter at birth ( P = .412) or the funduscopic findings ( P = .510). PR-VEP in children with congenital Zika syndrome and no funduscopic findings was significantly worse than in the control group ( P = .001). Conclusions: Children with congenital Zika syndrome have characteristically abnormal PR-VEPs regardless of the funduscopic findings and severe microcephaly. The PR-VEP findings supported the diagnosis of cortical visual impairment in these children. [ J Pediatr Ophthalmol Strabismus . 2021;58(2):78–83.]

[Retracted] Analysis of the Clinical Effect of Visual Electrophysiological Examination Combined with Targeted Health Education Nursing in Children

“…The increased level of attention that human beings pay to ophthalmic disorders has led to continuous developments in visual electrophysiological technology [ 4 , 5 ]. Visual electrophysiological examination is a noninvasive, objective, and quantitative examination method that can reflect the dysfunction of the visual system from the retina to the visual center.…”

Bateria de testes da função visual de comportamentos oculomotores: dados normativos e comparativos de recém-nascidos prematuros e termos brasileiros

“…O segundo recurso mais utilizado foram os PVE, os quais avaliam a integridade funcional das vias visuais da retina (Creel, 2019). Trata-se de um instrumento amplamente utilizado na pesquisa científica neonatal para avaliar desfechos visuais em diagnósticos distintos como glaucoma (ElBahwash et al, 2021), crescimento neonatal (Piro et al, 2020), síndrome congênita do zika vírus (Almeida et al, 2021), encefalopatia hipóxico-isquêmica (Kamino et al, 2021), entre outros. Dificilmente é utilizado na prática clínica profissional devido ao alto custo para aquisição dos equipamentos e exigir técnicas aprimoradas para sua reprodução (Salomão, 1996) devido a sua resposta complexa resultante de vários componentes, como o eletroencefalograma (Creel, 2019).…”