Patterned iridium oxide film as neural electrode interface: Biocompatibility and improved neurite outgrowth with electrical stimulation

Chen, Cen; Ruan, Shichao; Bai, Xue; Lin, Chen‐Ming; Xie, Changhao; Lee, In-Seop

doi:10.1016/j.msec.2019.109865

Cited by 32 publications

(29 citation statements)

References 58 publications

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“…In the presence of 100 mA monophasic ES, the osteoblasts elongation and proliferation were mainly reliant on the ES, whereas the topographical features played a minor role [84]. In our present study [90], perpendicular electrical field vectors from the pattern may reorientate the PC-12 cell alignment, while parallel vectors could further increase neuritis extension compared with perpendicular vectors. On the contrary, some types of cell are aligned perpendicular to the vectors under ES.…”

Section: Introductionmentioning

confidence: 60%

“…Some types of cell are aligned perpendicular to the direction of the electric field vectors to minimize the field gradient across the cell, such as cardiac adipose tissue-derived progenitor cells [18], endothelial progenitor cells [87], vascular ECs [77], BMSCs [88], adipose-derived stromal cells [89], etc. At the same time, some cells are aligned parallel to the field vectors due to the ES causes rearrangement of the cell cytoskeleton, such as ventricular myocytes [20], cardiomyocytes [86], myoblasts [85], PC-12 cells [90], obsteoblasts [84], etc. The ES intensity usually < 10 V/cm, and the cells aligned better with the ES intensity increased, but the cell activity is relatively decreased [77, 87, 91].…”

Section: Introductionmentioning

confidence: 99%

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Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

et al. 2019

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Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed.

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Section: Introductionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

et al. 2019

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“…Ir/IrOx (iridium oxide) is another prevailing electrode material and often used in the format of either a bulky wire or a thin film coating (Zeng et al, 2017;Black et al, 2018b;Chen et al, 2019;Ghazavi et al, 2020). Ir wires are very stiff and highly resistant to corrosion (Loeb et al, 1995), whereas IrOx thin films are unstable and prone to degradation as electrode dimensions decrease and charge densities increase (Cogan et al, 2004).…”

Section: Metalsmentioning

confidence: 99%

“…The design consideration of neural stimulation electrodes is similar to that of neural recording electrodes, concerning biocompatibility, mechanical properties, electrical properties, and stability (Shepherd et al, 2018). For example, platinum black and Ir/IrOx are also widely used as stimulating electrodes (Zhang et al, 2015;Chen et al, 2019). Large charge storage capacity is specifically required for simulating electrodes to achieve better stimulating performance (Hudak et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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“…The metal electrode (gold, platinum, and silver) was coated by conducting materials through chemical and electrochemical deposition. The conducting materials including graphene and graphene oxide (GO) [63], iridium oxide (IrO x ) [64], carbon nanotubes (CNTs) [65], and ICPs [66]. ICPs with high conductivity, excellent charge transport capacity, and good biocompatibility were speculated as promising electrode materials for nextgeneration neural electronics with reduced neural interfacing impedance.…”

Section: Conducting Polymer-based Compositementioning

confidence: 99%

Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

Liu

Yin

Chen

et al. 2020

International Journal of Polymer Science

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Conducting polymer-based composites have recently becoming popular in both academic research and industrial practices due to their high conductivity, ease of process, and tunable electrical properties. The multifunctional conducting polymer-based composites demonstrated great application potential for in vivo therapeutics and implantable electronics, including drug delivery, neural interfacing, and minimally invasive electronics. In this review article, the state-of-the-art conducting polymerbased composites in the mentioned biological fields are discussed and summarized. The recent progress on the synthesis, structure, properties, and application of the conducting polymer-based composites is presented, aimed at revealing the structure-property relationship and the corresponding functional applications of the conducting polymer-based composites. Furthermore, key issues and challenges regarding the implantation performance of these composites are highlighted in this paper.An efficient drug delivery system that can deliver the drug to targeted body sites and control the drug release rate precisely is able to improve the therapeutic outcomes and reduce the side effects [36,37]. Structuring such drug delivery systems has been long dreamed of and became more and more practical with the development of a variety of polymer-based delivery systems. From nonbiodegradable diffusion-controlled membranes [38] to biodegradable systems with a combination of diffusion and polymer matrix degradation [39], the polymer-based delivery system has shown enormous benefits in drug delivery and release. And since the 1980s, an effective and intelligent drug delivery system based on the ICPs has been developed [40,41]. Resulting from their inherent electrical, magnetic, and optical properties, the ICPs, especially their composites, are 2

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Patterned iridium oxide film as neural electrode interface: Biocompatibility and improved neurite outgrowth with electrical stimulation

Cited by 32 publications

References 58 publications

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

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