Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

Larson, John; Wong, Darryl; Lynch, Gary

doi:10.1016/0006-8993(86)90579-2

Cited by 965 publications

(575 citation statements)

References 7 publications

Supporting

Mentioning

558

Contrasting

Unclassified

Order By: Relevance

“…In each case, this model qualitatively replicates experimental data and the results of previous modelling studies -both solely pre-synaptic TBS and simultaneous pre-and postsynaptic TBS generating saturated LTP with a final synaptic weight of 1.89 ± 0.01 [48,[60][61][62].…”

Section: Induction Of Synaptic Plasticity By Other Stimulation Protocolssupporting

confidence: 79%

Calcium control of triphasic hippocampal STDP

Bush¹,

Jin

2012

J Comput Neurosci

View full text Add to dashboard Cite

Synaptic plasticity is believed to represent the neural correlate of mammalian learning and memory function. It has been demonstrated that changes in synaptic conductance can be induced by approximately synchronous pairings of pre-and post-synaptic action potentials delivered at low frequencies. It has also been established that NMDAr-dependent Calcium influx into dendritic spines represents the critical signal for plasticity induction, and can account for this spike-timing dependent plasticity (STDP) as well as experimental data obtained using other stimulation protocols. However, subsequent empirical studies have delineated a more complex relationship between spike-timing, firing rate, stimulus duration and post-synaptic bursting in dictating changes in the conductance of hippocampal excitatory synapses. It has yet to be established whether the Calcium control hypothesis can account for this more recent data. Here, we present a detailed biophysical model of single dendritic spines on a CA1 pyramidal neuron, describe the NMDAr-dependent Calcium influx generated by different stimulation protocols, and present a parsimonious model of Calcium driven kinase and phosphotase dynamics that dictate transitions between binary synaptic weight states. We demonstrate the manner in which this model can account for various experimental observations of synaptic plasticity and be used to make predictions regarding the dynamics of depolarisation and NMDAr activation generated by STDP protocols as well as the synaptic weight change induced under other experimental conditions. We then discuss how this parsimonious, unified computational model of synaptic plasticity might be utilised to appraise the activity-dependent refinement of neural circuitry induced by more realistic firing patterns. IntroductionSynaptic plasticity -the process of activity dependent change in synaptic conductance -is widely believed to represent the neural correlate of mammalian learning and memory function [1][2][3]. Since the first experimental demonstrations of long-term potentiation (LTP) and depression (LTD), a wealth of empirical data regarding the induction, expression and maintenance of synaptic plasticity in different cortical regions has been obtained [4][5][6][7][8]. In spite of the heterogeneity of plasticity mechanisms observed throughout the brain, changes in the strength of excitatory synapses afferent on CA1 pyramidal neurons in the hippocampus represent the best studied form in the mammalian cortex [9][10][11][12]. At these synapses, Calcium influx into dendritic spines represents the critical signal for synaptic plasticity induction [13][14][15][16][17][18][19][20]. Large, transient elevations in intracellular [Ca 2+ ] generate LTP via the preferential activation of kinase pathways while modest, sustained elevations in intracellular [Ca 2+ ] generate LTD via the preferential activation of phosphotase pathways [21][22][23][24][25]. Initially, empirical observations of synaptic plasticity were mediated by tetanic stimulation protoc...

show abstract

Section: Induction Of Synaptic Plasticity By Other Stimulation Protocolssupporting

confidence: 79%

Calcium control of triphasic hippocampal STDP

Bush¹,

Jin

2012

J Comput Neurosci

View full text Add to dashboard Cite

show abstract

“…For example, in rabbits, hippocampal theta activity pre dicts the learning rate of classical conditioning, whereas its loss impairs spatial memory in rats (Winson, 1978). In addition to these observations, it was found that theta bursts can induce long term potentiation (LTP) of synapses in hippocampus (Larson et al, 1986;Larson and Munkácsy, 2015), suggesting a physiological mechanism by which theta oscillations could mediate memory storage processes.…”

Section: Introductionmentioning

confidence: 95%

Slow-theta power decreases during item-place encoding predict spatial accuracy of subsequent context recall

et al. 2016

View full text Add to dashboard Cite

a b s t r a c tHuman hippocampal theta oscillations play a key role in accurate spatial coding. Associative encoding involves similar hippocampal networks but, paradoxically, is also characterized by theta power decreases. Here, we inves tigated how theta activity relates to associative encoding of place contexts resulting in accurate navigation. Using MEG, we found that slow theta (2 5 Hz) power negatively correlated with subsequent spatial accuracy for vir tual contextual locations in posterior hippocampus and other cortical structures involved in spatial cognition. A rare opportunity to simultaneously record MEG and intracranial EEG in an epilepsy patient provided crucial in sights: during power decreases, slow theta in right anterior hippocampus and left inferior frontal gyrus phase led the left temporal cortex and predicted spatial accuracy. Our findings indicate that decreased slow theta activ ity reflects local and long range neural mechanisms that encode accurate spatial contexts, and strengthens the view that local suppression of low frequency activity is essential for more efficient processing of detailed information.

show abstract

“…Synaptic responses were digitized and stored online using Igor™ software (Wavemetrics). LTP was induced using a theta burst stimulation (TBS: four trains, each consisting of ten 100 Hz bursts (four pulses) given at 5 Hz, repeated at 10 sec intervals) (Larson et al, 1986). LTD was elicited using a paired-pulse 1 Hz protocol (PP-1 Hz: pairedpulses of 50 ms interstimulus interval (ISI) repeated at 1 Hz for 15 min) (Lee et al, 2003) or a standard 1 Hz (15 min) protocol (Dudek and Bear, 1992).…”

Section: Hippocampal Slice Preparation and Electrophysiologymentioning

confidence: 99%

Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors

Lee

Takamiya

Kameyama³

et al. 2007

Molecular and Cellular Neuroscience

View full text Add to dashboard Cite

Phosphorylation of various AMPA receptor subunits can alter synaptic transmission and plasticity at excitatory glutamatergic synapses in the central nervous system. Here, we identified threonine-840 (T840) on the GluR1 subunit of AMPA receptors as a novel phosphorylation site. T840 is phosphorylated by protein kinase C (PKC) in vitro, and is a highly turned-over phosphorylation site in the hippocampus. Interestingly, the high basal phosphorylation of T840 in the hippocampus is maintained by a persistent activity of a protein kinase, which is counter-balanced by a basal protein phosphatase activity. To study the function of T840, we generated a line of mutant mice lacking this phosphorylation site using a gene knock-in technique. The mice generated lacks T840, in addition to two previously identified phosphorylation sites S831 and S845. Using this mouse, we demonstrate that T840 may regulate synaptic plasticity in an age-dependent manner.Many of the brain functions critically depend on plasticity of the glutamatergic excitatory synaptic transmission, which can be accomplished postsynaptically by modulation of glutamate receptors. AMPA-type glutamate receptors mediate the majority of fast excitatory synaptic transmission, and functional changes to these receptors are implicated in synaptic plasticity (Song and Huganir, 2002, Collingridge et al., 2004). One way to alter the function of AMPA receptors is by changing phosphorylation of its subunits. All four subunits of AMPA receptors, GluR1-4, which have several identified phosphorylation sites on their intracellular carboxy-terminus (Song and Huganir, 2002).Among the four subunits, GluR1 has three identified phosphorylation sites, serines 818 (S818) (Boehm et al., 2006), 831 (S831) and 845 (S845) (Roche et al., 1996). S831 is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) and protein kinase C (PKC), S845 is a cAMP-dependent protein kinase (PKA) substrate (Roche et al., 1996, Barria et al., 1997a, Mammen et al., 1997, while S818 is phosphorylated by PKC (Boehm et al., 2006). Changes in phosphorylation of GluR1 at S845 and S831 affect AMPA receptor mediated currents (Derkach et al., 1999, Banke et al., 2000, and are involved in long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus (Barria et al., 1997b, Kameyama Correspondence to: Hey-Kyoung Lee. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. , Lee et al., 2003. Recent data suggests that S845 and S818 affect the trafficking AMPA receptors to synapses and/or stabilize synaptic AMPA receptors (Esteban et al., 2003,...

show abstract

Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

Cited by 965 publications

References 7 publications

Calcium control of triphasic hippocampal STDP

Calcium control of triphasic hippocampal STDP

Slow-theta power decreases during item-place encoding predict spatial accuracy of subsequent context recall

Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors

Contact Info

Product

Resources

About