Patterning of multicomponent elastic shells by gaussian curvature

Waltmann, Curt; Shrestha, Ahis; Olvera de la Cruz, Monica

doi:10.1103/physreve.109.054409

Cited by 2 publications

References 72 publications

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Switchable Conformation in Protein Subunits: Unveiling Assembly Dynamics of Icosahedral Viruses

Li,

Tresset,

Zandi

2024

Preprint

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The packaging of genetic material within a protein shell, called the capsid, marks a pivotal step in the life cycle of numerous single-stranded RNA viruses. Understanding how hundreds, or even thousands, of proteins assemble around the genome to form highly symmetrical structures remains an unresolved puzzle. In this paper, we design novel subunits and develop a model that enables us to explore the assembly pathways and genome packaging mechanism of icosahedral viruses, which were previously inaccessible. Using molecular dynamics (MD) simulations, we observe capsid fragments, varying in protein number and morphology, assembling at different locations along the genome. Initially, these fragments create a disordered structure that later merges to form a perfect symmetric capsid. The model demonstrates remarkable strength in addressing numerous unresolved issues surrounding virus assembly. For instance, it enables us to explore the advantages of RNA packaging by capsid proteins over linear polymers. Our MD simulations are in excellent agreement with our experimental findings from small-angle X-ray scattering and cryo-transmission electron microscopy, carefully analyzing the assembly products of viral capsid proteins around RNAs with distinct topologies.

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Switchable Conformation in Protein Subunits: Unveiling Assembly Dynamics of Icosahedral Viruses

Li,

Tresset,

Zandi

2024

Preprint

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Research on the Construction of College Career Education Curriculum System and Innovation of Teaching Methods Driven by Innovative Technology

Wen,

Zhan

2024

Applied Mathematics and Nonlinear Sciences

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This paper aims to address the current situation of low career maturity among students in colleges and universities, as well as the insufficient professional level of career education teachers. It proposes a personalized recommendation system for career learning, utilizes innovative technology in the classroom, and develops a career education curriculum system with the core values of “Knowing, Acting, Saving.” The standardized scoring design is based on mean-centering, and the user similarity and time function are introduced for similarity calculation to provide personalized recommendations for career learning. Based on virtual reality technology, a virtual scene for career education is built, and an improved QEM grid simplification algorithm with edge segmentation is proposed to simplify the complex 3D grid model and provide students with virtual contextual classroom services. S The University of Shandong Province, China, conducts career education practice with Class 1 students majoring in biological sciences as the research object. The mean values of students’ knowledge, content, interest, awareness, and behavior dimensions in career maturity increased by 1.56, 0.83, 1.65, 1.3, and 1.03, respectively, compared to pre-practice. The overall career development water mean increased from 34.71 to 48.78 before the practice, which showed a significant difference (P<0.05), and the level of career education at the University of S is performing well.

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Patterning of multicomponent elastic shells by gaussian curvature

Cited by 2 publications

References 72 publications

Switchable Conformation in Protein Subunits: Unveiling Assembly Dynamics of Icosahedral Viruses

Switchable Conformation in Protein Subunits: Unveiling Assembly Dynamics of Icosahedral Viruses

Research on the Construction of College Career Education Curriculum System and Innovation of Teaching Methods Driven by Innovative Technology

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