Patterning the cerebral cortex into distinct functional domains during development

Appan, Dhivya; Hsu, Shu-Meng; Hsu, Wen-Hsin; Chou, Shen-Ju

doi:10.1016/j.conb.2023.102698

Cited by 3 publications

(1 citation statement)

References 85 publications

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“…Furthermore, while gradient 1 described a prototypical relationship between the thickness and density of tissue in the cortical sheet, gradient 2 captures how these two features diverge from this canonical relationship and exhibits greater behavioral relevance across a range of visual behaviors. This might suggest that the patterning of cortex into distinct cortical regions necessitates deviation from a canonical cortical sheet, reminiscent of the protocortex hypothesis of gestational neurodevelopment in which largely similar progenitor cells in the primordial cortex differentiate as a result of distinct thalamic inputs across cortex [76][77][78] . The morphological changes during gestation that lead to arealization of cortex into distinct regions are certainly distinct from the childhood structural measures quantified here through MRI, but may nonetheless suggest that the ontogenetic routines which serve to differentiate cortex into cytoarchitectonically distinct zones during gestation likely have long-term influences on the postnatal development observed here.…”

Section: Discussionmentioning

confidence: 99%

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Chen,

Liu,

Hoyos

et al. 2023

Preprint

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The microstructure of cells within human cerebral cortex varies across the cortical ribbon, where changes in cytoarchitecture and myeloarchitecture are thought to endow each region of cortex with its unique function. While fine-scale relative to a cell, these population-level changes impact architectural properties of cortex measurable in vivo by noninvasive MRI, such as the thickness and myelin content of cortex. This raises the question of whether or not we can use these in vivo architectural measures to understand cortical organization, function, and development more broadly. Using human visual cortex as a test bed, we found two architectural gradients, which not only underlie its structural and functional organization, but additionally predict the presence of new visual field maps and capture the lifespan trajectory and its behavioral relevance. These findings provide a more general framework for understanding visual cortex, showing that architectural gradients are a measurable fingerprint of functional organization and ontogenetic routines in the human brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Chen,

Liu,

Hoyos

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Chen,

Liu,

Hoyos

et al. 2024

Preprint

View full text Add to dashboard Cite

The microstructure of cells within human cerebral cortex varies across the cortical ribbon, where changes in cytoarchitecture and myeloarchitecture are thought to endow each region of cortex with its unique function. While fine-scale relative to a cell, these changes at population level impact architectural properties of cortex measurable in vivo by noninvasive MRI, such as the thickness and myelin content of cortex. This raises the question of whether or not we can use these in vivo architectural measures to understand cortical organization, function, and development more broadly. Using human visual cortex as a test bed, we demonstrated two architectural gradients, one in which cytoarchitecture and myeloarchitecture converge and another in which they diverge. These two gradients underlie the structural and functional topography of visual cortex, even predicting the presence of new visual field maps. Moreover, the two gradients show distinct visual behavior relevance and lifespan trajectory. These findings provide a more general framework for understanding human cortex, showing that architectural gradients are a measurable fingerprint of functional organization and ontogenetic routines in the human brain.

show abstract

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Chen,

Liu,

Hoyos

et al. 2024

Preprint

View full text Add to dashboard Cite

The microstructure of cells within human cerebral cortex varies across the cortical ribbon, where changes in cytoarchitecture and myeloarchitecture are thought to endow each region of cortex with its unique function. While fine-scale relative to a cell, these changes at population level impact architectural properties of cortex measurable in vivo by noninvasive MRI, such as the thickness and myelin content of cortex. This raises the question of whether or not we can use these in vivo architectural measures to understand cortical organization, function, and development more broadly. Using human visual cortex as a test bed, we demonstrated two architectural gradients, one in which cytoarchitecture and myeloarchitecture converge and another in which they diverge. These two gradients underlie the structural and functional topography of visual cortex, even predicting the presence of new visual field maps. Moreover, the two gradients show distinct visual behavior relevance and lifespan trajectory. These findings provide a more general framework for understanding human cortex, showing that architectural gradients are a measurable fingerprint of functional organization and ontogenetic routines in the human brain.

show abstract

Patterning the cerebral cortex into distinct functional domains during development

Cited by 3 publications

References 85 publications

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

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