Patterns and Determinants of Inappropriate Antibiotic Use in Injection Drug Users

Starrels, Joanna L.; Barg, Frances K.; Metlay, Joshua P.

doi:10.1007/s11606-008-0859-7

Cited by 17 publications

(6 citation statements)

References 40 publications

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“…In the clinical settings, inappropriate use accounts for 20%–50% of the antibiotics consumed [ 6 ]. These include the use of antimicrobials for viral infections, the prescription of broad-spectrum antibiotics, non-compliance to a treatment regimen by the patient, and incorrect dosage or duration [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Food Production Environment and the Development of Antimicrobial Resistance in Human Pathogens of Animal Origin

et al. 2017

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Food-borne pathogens are a serious human health concern worldwide, and the emergence of antibiotic-resistant food pathogens has further confounded this problem. Once-highly-efficacious antibiotics are gradually becoming ineffective against many important pathogens, resulting in severe treatment crises. Among several reasons for the development and spread of antimicrobial resistance, their overuse in animal food production systems for purposes other than treatment of infections is prominent. Many pathogens of animals are zoonotic, and therefore any development of resistance in pathogens associated with food animals can spread to humans through the food chain. Human infections by antibiotic-resistant pathogens such as Campylobacter spp., Salmonella spp., Escherichia coli and Staphylococcus aureus are increasing. Considering the human health risk due to emerging antibiotic resistance in food animal–associated bacteria, many countries have banned the use of antibiotic growth promoters and the application in animals of antibiotics critically important in human medicine. Concerted global efforts are necessary to minimize the use of antimicrobials in food animals in order to control the development of antibiotic resistance in these systems and their spread to humans via food and water.

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Section: Introductionmentioning

confidence: 99%

The Food Production Environment and the Development of Antimicrobial Resistance in Human Pathogens of Animal Origin

et al. 2017

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“…Self-treatment or street-treatment procedures are often performed by untrained individuals in nonsterile environments and may increase the risk for further complications. Studies have shown that 27–40% of IDUs had at least once lanced their own abscess, and 16–26% had self-medicated with illegally purchased antibiotics (Binswanger et al, 2000; Starrels, Barg, & Meglay, 2008; Takahashi, Baernstein, Binswanger, Bradley, &Merrill, 2007). The improper use of antibiotics has resulted in a growing medical concern over the development of drug-resistant strains of bacteria; this may be further exasperated by the self-medication of abscesses by IDUs (Levy, 1998).…”

Section: Introductionmentioning

confidence: 99%

Abscess and Self-Treatment Among Injection Drug Users at Four California Syringe Exchanges and Their Surrounding Communities

Fink¹,

Lindsay²,

Slymen³

et al. 2013

Substance Use & Misuse

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This study aimed to identify the prevalence and determinants of soft tissue infections and self-treatment among injection drug users (IDUs) in California. The study interviewed 864 IDUs in California using computer-assisted personal interview (CAPI) from 2003 to 2005. Multiple logistic regression analyses were performed to examine adjusted associations for recent abscess and abscess self-treatment. In these analyses, Latinos had higher odds than African Americans to self-treat, while IDUs reporting a usual place of health care had lower odds of self-treatment. Findings suggest an expansion of wound care facilities to mitigate the self-treatment of abscesses, with special consideration to Latinos.

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“…The control of MRSA nosocomial infections is, many times, very difficult because of the presence of this prevalent clone. Additionally, many antibiotics are associated with adverse effects (Starrels et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Ruela¹,

Leal²,

Almeida³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In order to validate the Bumelia sartorum Mart., Sapotaceae, traditional use for infection diseases, this study evaluates the antibacterial activity of the stem bark fractions against methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus strains by using the agar dilution method and reported as MIC (minimal inhibitory concentration). In addition, the DPPH scavenging activity of these fractions was measured and the chemical composition and acute toxicity of the active fraction were also determined. The ethyl acetate (EtOAc) extract was chemically analyzed by LC/ MS, direct ionization APCI/MS, 1 H NMR and 13 C-NMR. All fractions, except butanol extract, presented high antioxidant activity, especially the methanol and the EtOAc extracts, which showed EC50 values (5.67 and 5.30 µg/mL, respectively) considerably lower than the Gingko-standard EGb 761 ® (38.58 µg/ mL). The antibacterial activity against S. aureus strains was observed in EtOAc (MIC 256-512 µg/mL), which showed a very low toxicity. The chemical study of this fraction revealed the abundant presence of polyphenolic compounds. The antibacterial and antioxidant activities reported in this paper for EtOAc extract from B. sartorum and the low toxicity of this fraction opens the possibility that it could be helpful for the developing of new antibacterial agents for treating S. aureus infections.

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Patterns and Determinants of Inappropriate Antibiotic Use in Injection Drug Users

Cited by 17 publications

References 40 publications

The Food Production Environment and the Development of Antimicrobial Resistance in Human Pathogens of Animal Origin

The Food Production Environment and the Development of Antimicrobial Resistance in Human Pathogens of Animal Origin

Abscess and Self-Treatment Among Injection Drug Users at Four California Syringe Exchanges and Their Surrounding Communities

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

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