Patterns and predictors of anxiety and depression symptom trajectories in patients diagnosed with primary brain tumors

Ernster, Alayna E.; Body, Anjelica; Deleyrolle, Phuong; St. Clair, Jennifer; Sampson, Deborah; Bacharz, Kelsey; Yan, Sandra C.; Melnick, Kaitlyn; Allen, Annie; Rahman, Maryam; Tran, David D.; Mitchell, Duane A.; Pereira, Deidre B.; Ghiaseddin, Ashley P.

doi:10.1007/s11060-023-04469-2

Cited by 3 publications

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Baseline factors relating to depressive symptoms at one year postoperative in patients with diffuse glioma

Belgers,

Tolver,

Klein

et al. 2024

Neuro-Oncology Practice

View full text Add to dashboard Cite

Background Depressive symptoms are common in patients with diffuse glioma, potentially reducing their quality of life. Understanding baseline factors associated with the development of depressive symptoms is important for psychoeducation and early intervention. This study investigates the associations of baseline patient- and tumor-related characteristics and depressive symptoms one year after surgery. Methods We combined retrospective longitudinal datasets from Amsterdam UMC and Rigshospitalet Copenhagen. Several characteristics of patients and tumors were retrieved, in particular items of their mood and functioning status. Depression instruments were harmonized to the PROMIS Depression scale through previously-developed item response theory. Functioning items were harmonized to the International Classification of Functioning, Disability and Health (ICF) domains using linking methods published previously. We analyzed the associations of 25 baseline factors with depressive symptoms one year after surgery by multivariable stepwise backward linear regression models and verified model robustness using best subset selection. Results We included 118 patients with diffuse glioma with a mean age of 48 years and a glioblastoma in 29%. Baseline depressive symptoms, lower ICF energy, and impaired ICF language functioning were associated with more depressive symptoms at follow-up in the multivariable model (R-squared: 0.379). Conclusions We identified three key baseline factors associated with depressive symptoms one year after surgery. Clinically, our findings contribute to the comprehension of predictive factors for depressive symptoms, aiding healthcare providers and patients in understanding and possibly allowing for early intervention.

show abstract