Tooth loss is one of the major social and aesthetic embarrassments. It causes negative impact on quality of life. It's not only affect speech and mastication but also affects overall well-Background: Tooth extraction causes a negative impact on the quality of life. It does not only affect speech and mastication but also affects overall well-being. There are numerous factors for tooth extraction. Tooth extraction is gaining popularity worldwide because tooth loss remains an imperative subject in public health. Objective: To determine the frequency of different factors leading to tooth extraction in patients visiting tertiary care hospital. Material and Methods: The cross-sectional study was carried out in Dow University of Health Sciences, Pakistan. Adult patients of age 20 to 60 years of either gender with permanent teeth presenting with pain and sensitivity were included in the study through non-probability consecutive sampling technique. All the details were recorded in a well-designed performa. Sample size calculation was done using the WHO sample size calculator. Data were analyzed through SPSS software. Results: The mean age +/-SD of subjects was 41.64 ± 15.02 (8-85) years. Out of 520 patients, 49.2% of patients had their extraction in the lower arch whereas 44.6% of patients had extractions in the upper arch. In addition, 56.4% of patients had their molar tooth extracted. 77.5% of patients had caries and % patients had periodontal disease, 7.9% patients that underwent tooth extraction had hypertension, and 2.9% had diabetes. Patients with age less than 40 years had statistically significant relation with caries. And patients with more than 40 years had statistically significant relation with periodontal disease. (P value= < 0.05). Conclusion: It is recommended to have proper screening, regular monitoring and strategic planning of whole dentition for caries, periodontal disease, diabetes and hypertension among the general population so that there is regular dental checkup. This approach could lead to decrease in morbidity and mortality of dentition. We also recommend improved accessibility of oral healthcare facilities, intensification of oral healthcare awareness campaigns, and fluoridation of community water supply. being. It is very substantial to collect data from all over the world regarding dental status and keeping it accurate for community awareness [1]. In the past decade, researches have shown that tooth extraction is gaining popularity worldwide because tooth loss remains an imperative subject in public health.