Patterns and treatment of neck metastases in patients with salivary gland cancers

Yoo, Shin Hyuk; Roh, Jong–Lyel; Kim, Seon‐Ok; Cho, Kyung–Ja; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon

doi:10.1002/jso.23914

Cited by 50 publications

(72 citation statements)

References 25 publications

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“…A study by Han et al reported an occult metastatic rate of 20% among patients with submandibular gland cancer. Most specialists recommend END for all high‐grade tumors, excluding ACC, which is in line with our study because ACCs carried a metastatic rate of only 7%. Hirvonen et al found that 12% of patients with major salivary gland ACC presented with pN+.…”

Section: Discussionsupporting

confidence: 87%

“…Thus, the diagnostics and treatment of salivary gland carcinomas differ from other head and neck carcinomas, of which over 90% are squamous cell carcinomas (SCCs). Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are among the most frequent malignancies encountered in the major salivary glands . Treatment recommendations for salivary gland carcinomas are usually based on parotid gland tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment recommendations for salivary gland carcinomas are usually based on parotid gland tumors. Still, the biological behaviors of parotid and submandibular gland tumors can vary …”

Section: Introductionmentioning

confidence: 99%

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Submandibular gland cancer: Specific features and treatment considerations

et al. 2017

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Submandibular gland cancer: Specific features and treatment considerations

et al. 2017

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“…Whether to choose neck dissection for patients with cN0 disease with salivary gland carcinoma is controversial. Patients with high‐grade carcinoma should receive elective neck dissection . Nevertheless, for patients with cN0 disease refusing to receive radical surgery, it was reasonable to detect neck failure during the follow‐up.…”

Section: Discussionsupporting

confidence: 53%

Postoperative iodine‐125 interstitial brachytherapy for the early stages of minor salivary gland carcinomas of the lip and buccal mucosa with positive or close margins

Shao

Huang

et al. 2017

Head & Neck

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“…On multivariate analysis, lymphovascular invasion was the only prognostic factor for overall survival [1] and was also an independent predictor of recurrence [13,37]. Other tumor-related histologic factors independently associated with decreased survival are perineural involvement of a major nerve [8,24] and solid histological subtype of AdCC [16,17,21,30,35].…”

Section: Incidence and Consequences Of Cervical Lymph Node Metastasismentioning

confidence: 99%

Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review

et al. 2016

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The purpose of this study was to establish general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0–14% of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15% to 44%, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.

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Patterns and treatment of neck metastases in patients with salivary gland cancers

Abstract: Patients with high-grade cancers should receive END involving levels I-III, whereas patients with node-positive salivary cancers should receive comprehensive TND involving all levels (I-V).

Cited by 50 publications

References 25 publications

Submandibular gland cancer: Specific features and treatment considerations

Submandibular gland cancer: Specific features and treatment considerations

Postoperative iodine‐125 interstitial brachytherapy for the early stages of minor salivary gland carcinomas of the lip and buccal mucosa with positive or close margins

Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review

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