Patterns of allergen sensitization and self-reported allergic disease in parents of food allergic children

Makhija, Melanie; Robison, Rachel G.; Caruso, Deanna; Cai, Mingzhong; Wang, Xiaobin; Pongracic, Jacqueline A.

doi:10.1016/j.anai.2016.07.042

Cited by 13 publications

(7 citation statements)

References 29 publications

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“…Food allergy in pups of allergic mothers was examined because, pups of allergic mothers have elevated allergic lung responses to a suboptimal number of sensitizations with allergen, even if the allergen of the pup differs from the allergen of the mother 7, 8, 14, 15, 60, 61 . This is also evident in humans where family history of allergic disease is one of the strongest risk factors for development of atopic disease in children 4, 62–66 . It is not known whether offspring of allergic mothers respond to suboptimal food allergen sensitization.…”

Section: Resultsmentioning

confidence: 90%

“…Food-specific IgE is low in food allergic children and correlates poorly with food allergy 4 . IgG1 can also mediate peanut antigen-induced anaphylaxis in the absence of IgE in animal models 83 .…”

Section: Discussionmentioning

confidence: 99%

“…Food allergies often develop early in life. Offspring of allergic mothers or fathers have increased incidence of food allergies 4 . The risk for allergic disease in humans is associated with in utero and early exposures to environmental factors 5 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation

Walker

Green

Ferrie

et al. 2018

Journal of Allergy and Clinical Immunology

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show abstract

Section: Resultsmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation

Walker

Green

Ferrie

et al. 2018

Journal of Allergy and Clinical Immunology

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show abstract

“…With respect to food allergy the gold standard for determining the presence of food allergy in an individual is a double‐blind, placebo‐controlled oral food challenge or by measuring specific IgE concentrations to multiple foods with the latter having been shown to correlate poorly with self‐report food allergy . These methods, however, were not feasible in this large epidemiological study.…”

Section: Discussionmentioning

confidence: 94%

Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress

Koloski

Jones

Walker

et al. 2019

Aliment Pharmacol Ther

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Background:The pathogenesis of functional GI disorders (FGIDs) is uncertain. However, underlying immune activation and psychological distress has been documented in irritable bowel syndrome (IBS) and functional dyspepsia (FD). Epidemiological data from the UK suggest that FGIDs are linked to atopy and certain autoimmune diseases but this has not been confirmed.Aim: To test if allergic or autoimmune diseases are independently associated with FGIDs, irrespective of psychological distress in a large population based study. Methods:A total of 3542 people (mean age 57.9 years and 52.7% females) randomly selected from the Australian population, returned a mail survey (response rate = 43%). The survey asked about a physician diagnosis of autoimmune disease (scleroderma, psoriasis, rheumatoid arthritis and diabetes mellitus) or allergic conditions (asthma, food, pollen and/or animal allergy). The questionnaire assessed psychological distress and Rome III criteria for FD and IBS.Results: Asthma, food, pollen and animal allergies, psoriasis and rheumatoid arthritis were univariately significantly associated with IBS and FD. Food allergy (OR = 1.66; 95% CI = 1.15-2.40, P = 0.007), psoriasis (OR = 1.81; 95% CI = 1.19-2.74, P = 0.006) and rheumatoid arthritis (OR = 1.68; 95% CI = 1.15-2.4, P = 0.007) were independent risk factors for IBS, controlling for age, gender and psychological distress. In FD, asthma (OR = 1.32; 95% CI = 1.04-1.68, P = 0.025) and food allergy (OR = 1.78; 95% CI = 1.28-2.49, P = 0.001) were independent predictors, controlling for age, sex and psychological distress. Conclusions:There is evidence that both atopic and autoimmune diseases are risk factors for FGIDs, independent of psychological distress, differing in IBS and FD.This provides evidence that different peripheral pathways may be involved in the pathogenesis of certain FGIDs.

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“…Sensitization, or the presence of allergic antibody, is a pre-requisite for development of an allergic response to an allergen. Patterns of sensitization to environmental and food allergens have previously been studied in children in an effort to better understand allergy development [ 1 , 2 ]. A reaction to a food allergen can cause a wide range of clinical responses, ranging from urticaria to anaphylaxis, the most severe form of allergic reaction [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children

Gonzales-González

Díaz²,

Fernández³

et al. 2018

Allergy Asthma Clin Immunol

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BackgroundFood allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries. Honduras has no studies in pediatric patients.ObjectivesThe objective of this research was to identify the most common sensitization patterns to food through epicutaneous skin testing and food allergy rates in children and their correlation with common allergic diseases in a group of patients from Hospital of Pediatrics Maria.MethodsCross-sectional retrospective, descriptive study in which records and database of all allergic patients in the immunology outpatient clinic from Hospital of Pediatrics Maria were reviewed between the periods of January 2015 through June 2016.ResultsA total of 365 children were analyzed, the age of participants were in the range from 1 to 18 years, with an average of 9.8 years. Sensitization to food allergens were found in 23, and 58.3% were poly-sensitized. The most common food allergens that patients were sensitized to: milk 9.0%, eggs 6.9%, peanut 4.9% and pork meat 4.4%. Food allergy was confirmed via oral food challenged in 9.3% of the patients. The most frequent food allergies found were: cow’s milk allergy 6%, hen’s egg allergy 5.2% and wheat allergy 1.9%.ConclusionsMilk and egg were the most common a food allergens found in the population studied. Most of the patients were found to be poly-sensitized. The frequent food allergies confirmed via oral food challenge were cow’s milk allergy, hen’s egg allergy and wheat allergy.

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Patterns of allergen sensitization and self-reported allergic disease in parents of food allergic children

Cited by 13 publications

References 29 publications

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation

Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress

Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children

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