Patterns of antibodies to hepatitis C virus and hepatitis C virus replication in children with chronic non-A, non-B hepatitis

Bortolotti, Flavia; Vajro, Pietro; Barbera, Cristiana; Crivellaro, Carlo; Zancan, Lucia; Giacchino, Raffaella; Nebbia, Gabriella; Lepore, Loredana; Barbierato, Emanuele; Moliner, Lorena De; Cavalletto, D.; Alberti, Alfredo

doi:10.1016/s0022-3476(05)82009-8

Cited by 13 publications

(3 citation statements)

References 8 publications

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“…This phenomenon has been reported also in vertically infected immunocompetent infants (25) and in children (26). Thaler et al (25) found that all eight of the children they studied who were born to anti-HCV-positive and HCV-RNApositive mothers had HCV-RNA on several occasions during their first year of life, but none of these children actively produced anti-HCV antibodies.…”

Section: Discussionmentioning

confidence: 53%

Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV-Seronegative Pregnant Women: A 24-Month Prospective Study

Ceci

Margiotta²,

Marello³

et al. 2001

Journal of Pediatric Gastroenterology and Nutrition

128

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Section: Discussionmentioning

confidence: 53%

Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV-Seronegative Pregnant Women: A 24-Month Prospective Study

Ceci

Margiotta²,

Marello³

et al. 2001

Journal of Pediatric Gastroenterology and Nutrition

128

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“…Patients who had concomitant systemic diseases or other causes of chronic liver disease, such as chronic hepatitis B, autoimmune hepatitis, Wilson disease, or a-1-antitrypsin deficiency, were excluded from the study. Children observed before 1990 initially received a diagnosis of chronic non-A, non-B hepatitis by conventional exclusion criteria [17]. In these patients, diagnosis of CHC was made after the availability of a screening test for HCV.…”

Section: Patients Materials and Methodsmentioning

confidence: 99%

Chronic Hepatitis C in Childhood: An 18-Year Experience

Iorio¹,

Giannattasio²,

Sepe³

et al. 2005

Clinical Infectious Diseases

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“…Seronegative HCV infection (absence of a serologic response to HCV polypeptides) is a well-known entity; indeed, as much as 10% of viremic immunocompetent subjects do not have HCV antibodies (24). This phenomenon has been reported also in vertically infected immunocompetent infants (25) and in children (26). Thaler et al (25) found that all eight of the children they studied who were born to anti-HCV-positive and HCV-RNApositive mothers had HCV-RNA on several occasions during their first year of life, but none of these children actively produced anti-HCV antibodies.…”

Section: Table 2 Hcv-rna and Riba Data Of Babies Born To Hcv-rna-posi...mentioning

confidence: 97%

Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV‐Seronegative Pregnant Women: A 24‐Month Prospective Study

Ceci,

Margiotta,

Marello

et al. 2001

J. pediatr. gastroenterol. nutr.

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BackgroundMother to infant transmission of hepatitis C virus (HCV) has been extensively studied in mothers with human immunodeficiency virus (HIV) infection, whereas fewer data are available on the vertical HCV transmission in HIV‐negative women.MethodsBetween January 1995 and June 1997, 78 consecutive HCV‐positive/HIV‐negative women with their offspring entered this prospective study aimed to define the prevalence of and risk factors for HCV vertical transmission. Risk factors for HCV were carefully sought, and HCV viral load and genotype were determined in all positive mothers. The infants were tested for alanine aminotransferase (ALT) and HCV‐RNA at birth and at 4, 8, 12, 18, and 24 months of age.ResultsEight of 60 (13.3%) infants born to HCV‐RNA positive mothers acquired HCV infection, but only 2 (3,3%) were still infected by the end of follow‐up. Infants' genotypes matched that of the mothers. ALT levels were in the normal range in all study subjects throughout the follow‐up. High maternal viral load (P < 0.05), possession of HCV risk factors (P < 0.004), and history of blood transfusion (P < 0.05) were associated with increased risk of HCV vertical transmission.ConclusionsThis long‐term prospective study shows that, although vertical transmission from HIV‐negative mothers occurs in 13% of cases, there is a high rate of spontaneous viral clearance (75%). High maternal viral load and mothers belonging to HCV risk categories were the only variables predictive of the vertical transmission.

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Patterns of antibodies to hepatitis C virus and hepatitis C virus replication in children with chronic non-A, non-B hepatitis

Cited by 13 publications

References 8 publications

Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV-Seronegative Pregnant Women: A 24-Month Prospective Study

Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV-Seronegative Pregnant Women: A 24-Month Prospective Study

Chronic Hepatitis C in Childhood: An 18-Year Experience

Vertical Transmission of Hepatitis C Virus in a Cohort of 2,447 HIV‐Seronegative Pregnant Women: A 24‐Month Prospective Study

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