Patterns of antimicrobial therapy in severe nosocomial infections: empiric choices, proportion of appropriate therapy, and adaptation rates—a multicentre, observational survey in critically ill patients

Vogelaers, Dirk; Bels, David De; Forêt, Frédéric; Cran, Sophie; Gilbert, Eric; Schoonheydt, K.; Blot, Stijn

doi:10.1016/j.ijantimicag.2009.11.015

Cited by 78 publications

(39 citation statements)

References 59 publications

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“…Results are shown as n (%), mean ± SD where applicable a Hierarchical logistic regression with random effect for centre and country adequate therapy [23,24]. Bacterial resistance was also associated with mortality in recent, large, well-conducted epidemiological studies [2,25].…”

Section: Discussionmentioning

confidence: 99%

“…Results: We included 1,156 patients [mean ± standard deviation (SD) age, 59.5 ± 17.7 years; 65 % males; mean ± SD Simplified Acute Physiology Score (SAPS) II score, 50 ± 17] with HA-BSIs, of which 76 % were ICU-acquired. Median time to diagnosis was 14 [interquartile range (IQR), [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] days after hospital admission. Polymicrobial infections accounted for 12 % of cases.…”

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Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

et al. 2012

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

et al. 2012

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“…3 Infection control measures have important implications for daily practice, because the number of patients already colonized or infected with MDR organisms on arrival to the ICUs is increasing. 4 …”

Section: Introductionmentioning

confidence: 99%

Prevalence of nosocomial infections in the intensive care unit

Durgad¹,

Varadarajan²

2015

Int J Res Med Sci

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“…2,3 Entretanto o maior problema está relacionado com o uso de antimicrobianos, um vez que cerca de 50% das prescrições desses fármacos são desnecessárias ou inapropriadas e a razão fundamental de tal fato é o conhecimento insuficiente de informações cada vez mais vastas e complexas sobre diagnóstico e tratamento de doenças infecciosas. 7 As IRAS também estão associadas à resistência microbiana, pois quase 70% das infecções são devido a microrganismos resistentes a um ou mais antibióticos chamados de Multi Droga Resistentes (MDR).…”

Section: Métodosunclassified

Avaliação Da Prescrição De Antimicrobianos Para Infecção Relacionada À Assistência À Saúde Em Um Hospital Escola De Recife – Pe

Tavares

Veras

Silva

et al. 2015

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. //dx.doi.org/10.17058/reci.v5i3.5496 Recebido em: 31/12/2014 Aceito Background and Objectives: in Intensive Care Units (ICU) are the highest rates of Healthcare-associated infections (HAI).Antimicrobial therapy for these infections has become increasingly challenging due to high rates of antimicrobial resistance.Thus arises the need for appropriate antibiotic therapy. Thus arises the need to assess the antimicrobial therapy for patients with IRAS The study aims to evaluate antimicrobials prescriptions for patients diagnosed with HAI in the Adult ICU of a teaching hospital in Recife-PE in 2010. Methods: cross-sectional, descriptive, and retrospective study using the HAI reporting forms, prescriptions and medical records of patients aged from 18 years, in Adult ICU of the Instituto de Medicina IntegralProf. Fernando Figueira (IMIP). The variables analyzed in the study were gender, age, admission diagnosis, etiologic agent, Infection Related to Health Care, antibiotics, high and óbto. Data were collected from the analysis of HAI reporting forms, data collection form of HAI reporting forms and records and / or prescriptions. Results: the study population consisted of 31 notifications. The respiratory tract infections were the most frequent (80.6%). The microbiological confirmation was 83.9%, totaling 11 species of microorganisms, one of which being multiresistant. The use of 14 different antimicrobials was observed with monotherapy in a minority of cases. Only two patients underwent five schemes. Mistake regarding prescription was not observed, but misconceptions about some doses, intervals and as an association were highlighted.Conclusion: the indicators analyzed showed no significant discrepancies when compared with other national or international studies. One perceives the need for further studies on the use of antimicrobials. RESUMO ABSTRACT ARTIGO ORIGINALAvaliação da prescrição de antimicrobianos para infecção relacionada à assistência à saúde em um Hospital Escola de Recife -PE

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Patterns of antimicrobial therapy in severe nosocomial infections: empiric choices, proportion of appropriate therapy, and adaptation rates—a multicentre, observational survey in critically ill patients

Cited by 78 publications

References 59 publications

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

Prevalence of nosocomial infections in the intensive care unit

Avaliação Da Prescrição De Antimicrobianos Para Infecção Relacionada À Assistência À Saúde Em Um Hospital Escola De Recife – Pe

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