Patterns of arterial vascularization in swine hearts

Abstract

This study aimed to characterize the patterns of arterial vascularization in swine hearts. Ninety swine hearts were submitted to the Spalteholz diaphanization technique in order to dissect the coronary arteries. Three types of arterial vascularization patterns were characterized through the behaviorof the rami circumflexus and interventricularis, namely: balanced, right and left types. The balanced pattern was the most frequently (42.2%); in this case, the rami circumflexus and interventricularis occupied their respective sulci. The right type (40%) was further categorized into three vascularization subtypes. In the first, ramus circumflexus dexter branched from the ramus interventricularis subsinuosus. In the second, the arteria coronaria dextra branched from ramus interventricularis subsinuosus and ramus circumflexus. In the third model, arteria coronaria sinister branched from ramus interventricularis paraconalis. The left type (17.7%) exhibited two subtypes. In the first, ramus interventricularis paraconalis ran through the entire corresponding sulcus and the ventral third of sulcus interventricularis subsinuosus, and ramus interventricularis subsinuosus occupied the dorsal and middle third of its respective sulcus. In the second, ramus interventricularis subsinuosus branched from arteria coronaria dextra and ran through the dorsal and medium thirds of its respective sulcus, and the ventral third was occupied by the collateral branch of ramus circumflexus sinister. Our results reinforce the thesis that the blood distribution system through the coronary artery in swine is similar to human, not only in qualitative but also by a quantitative comparison.INDEX TERMS: Heart, cardiovascular system, coronary circulation, swine, animal models.

Hemangiossarcoma Cutâneo Em Gatos: Relato De Caso

“…Therefore, the need to choose a species that accurately resembles human cardiovascular anatomy and physiology is paramount (LELOVAS, KOSTOMITSOPOULOS and XANTHOS, 2014). Such need elects the domestic swine species as a model of choice for such experiments (PLATT et al, 2002;VIDOTTI et al, 2008;PINTO et al, 2016).…”

“…From its use within laboratories, a significant advance in the production of knowledge has already been achieved, especially concerning the remodeling of the left ventricle and extension of the affected area after myocardial ischemia (PINTO et al, 2016). Therapies with stem cell transplantation were also related (MIN et al, 2012;LI et al, 2013) in addition to the use of angiogenic growth factors in infarcted patients (DIXON and SPINALE, 2009), which demonstrates their role vital in translational research (SWINDLE et al, 2012).…”

Ciências veterinárias: Pensamento científico e ético 2

“…[40%] (PINTO et al, 2016). These distributions can be seen in Figure 1, which shows the arterial vascularization patterns found in swine hearts.…”

>b<Descelularização de coração suíno:>/b< caracterização e quantificação estereológica da matriz extracelular do ventrículo esquerdo

“…Para que este meio seja apropriado, é necessário que contenha MEC, uma vez que fornecem a estrutura adequada, guiando a formação de novos tecidos (GOLDBERG et al, 2003). (WINFREE, 1994;GREENE;BENSON, 2002;HAGHIGHI et al, 2003;GINIS et al, 2004 VIDOTTI et al, 2008;PINTO et al, 2016).…”

“…A partir da sua utilização dentro de laboratórios, um avanço significativo na produção de conhecimento já foi alcançado, principalmente no que tange à remodelação do ventrículo esquerdo e extensão da área afetada após isquemia miocárdica (PINTO et al, 2016). Também são relacionadas terapias com transplante de células-tronco (MIN et al, 2012;LI et al, 2013) (GETTY, 1975).…”