Patterns of breast cancer relapse

Elder, Elisabeth; Kennedy, Catherine; Gluch, Laurence; Carmalt, Hugh; Janu, Norman C.; Joseph, Mariamma; Donellan, M.J.; Molland, J. Gail; Gillett, David J.

doi:10.1016/j.ejso.2006.06.001

Cited by 70 publications

(71 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The technique was developed and applied by the Mastology Sector of the Clinics Hospital of Porto Alegre and has shown efficacy in patients with small breasts presenting with tumors in the inner and upper breast quadrants 20 . In our group of patients submitted to immediate fat grafting and with 36 months of follow-up, we observed no local recurrence and there was only one case of systemic recurrence, comparable to the systemic recurrence rates described in the literature 9,21 . Some studies have shown a greater number of local recurrence in patients with intraductal carcinoma undergoing fat grafting in late reconstruction, but the numbers were not significant, since the control population showed a lower recurrence rate than expected (1% per year) 5,7 .…”

Section: Discussionsupporting

confidence: 67%

Immediate reconstruction with autologous fat grafting: influence in loco regional recurrence in breast cancer

Stumpf

Biazús

Zucatto

et al. 2017

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

Objective: to evaluate local and systemic recurrence of breast cancer in patients submitted to autologous fat grafting in the immediate reconstruction after conservative surgery for breast cancer. Methods: this is a historical cohort study comparing 167 patients submitted to conservative surgery without reconstruction (conservative surgery group) with 27 patients submitted to conservative treatment with immediate graft reconstruction, following the Coleman's technique (lipofilling group). All patients had invasive carcinoma and were operated by a single surgeon from 2004 to 2011. The postoperative follow-up time was 36 months. Results: the overall incidence of local recurrence was 2.4%. No patient in the lipofilling group had local recurrence during the study period. For systemic recurrence, the rates obtained were 3.7% (one patient) for the fat grafting group and 1.8% (three patients) for the conservative surgery group without reconstruction. Conclusion: there was no significant difference for local or systemic recurrence in the groups studied. Immediate autologous fat grafting appears to be a safe procedure.

show abstract

Section: Discussionsupporting

confidence: 67%

Immediate reconstruction with autologous fat grafting: influence in loco regional recurrence in breast cancer

Stumpf

Biazús

Zucatto

et al. 2017

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

show abstract

“…[12,34] In this study the majority of metastases became manifest within 2.5 years of initial diagnosis, as observed by others. [11,13,35,36] The MCR hosts unique data on clinically evident metastases in follow-up, but the prevalence of metastases in the MCR is slightly underdocumented. Surgically treated and histopathologically confirmed metastases are obtained from pathology reports and are therefore nearly complete.…”

Section: Discussionmentioning

confidence: 99%

Unfavourable pattern of metastases in M0 breast cancer patients during 1978-2008: a population-based analysis of the Munich Cancer Registry

Hurk

Eckel

Poll‐Franse

et al. 2011

Breast Cancer Res Treat

View full text Add to dashboard Cite

Key words: metastases pattern, time to metastases, survival, breast cancer 2 ABSTRACT PurposeLittle is known about time trends in metastases in patients treated in routine health care facilities without metastases at diagnosis (M0) and about survival after these metastases. Methods Data ConclusionsIn the period 1978-2008, unfavourable changes in the pattern of metastases were exhibited and no improvement was observed in survival of patients after occurrence of metastases. An explanation might be the increased use of adjuvant systemic treatment, which has less effect on the highly lethal liver and CNS metastases than on bone metastases. The increased use also appeared to contribute to the overall prevention of metastases in breast cancer and therefore to improvement of overall survival.3

show abstract

“…A greater hazard rate for relapse during the first 3 years was just evident in the ATAC trial (The ATAC Trialists' Group, 2005), but reflects a higher rate of distant relapse in this period. Others have reported that the rate of locoregional relapse is initially high, and then falls off, so that most treatable relapses occur in the first 3 -5 years (Elder et al, 2006). However, these studies do not include new contralateral cancers.…”

Section: Discussionmentioning

confidence: 99%

Changing pattern of the detection of locoregional relapse in breast cancer: the Edinburgh experience

et al. 2007

View full text Add to dashboard Cite

The guidelines for follow-up of breast cancer patients concentrate on the first 3 -5 years, with either reduced frequency of visits or discharge after this. They also recommend mammography, but no evidence exists to inform frequency. We analyse treatable relapses in our unit from 1312 patients with early stage breast cancer treated by breast conserving surgery (BCS) and postoperative radiotherapy between 1991 and 1998 to assess appropriateness of the guidelines. A total of 110 treatable relapses were analysed. Treatable relapse developed at 1 -1.5% per year throughout follow-up. Forty-eight relapses were in ipsilateral breast, 25 ipsilateral axilla, 35 contralateral breast, 2 both breasts simultaneously. Thirty-seven relapses (33.5%) were symptomatic, 56 (51%) mammographically detected, 15 (13.5%) clinically detected, 2 (2%) diagnosed incidentally. Mammography detected 5.37 relapses per 1000 mammograms. Patients with symptomatic or mammographically detected ipsilateral breast relapse had significantly longer survival from original diagnosis (P ¼ 0.0002) and from recurrence (P ¼ 0.0014) compared with clinically detected. Treatable relapse occurs at a constant rate for at least 10 years. Clinical examination detects a minority (13.5%). Relapse diagnosed clinically is associated with poorer outcome. Long-term follow-up based on regular mammography is warranted for all patients treated by BCS.

show abstract

Patterns of breast cancer relapse

Cited by 70 publications

References 24 publications

Immediate reconstruction with autologous fat grafting: influence in loco regional recurrence in breast cancer

Immediate reconstruction with autologous fat grafting: influence in loco regional recurrence in breast cancer

Unfavourable pattern of metastases in M0 breast cancer patients during 1978-2008: a population-based analysis of the Munich Cancer Registry

Changing pattern of the detection of locoregional relapse in breast cancer: the Edinburgh experience

Contact Info

Product

Resources

About