Patterns of breathing movements in the near-term human fetus: relationship to behavioural states

Mulder, E.J.H.; Boersma, M.; Meeuse, M.; Wal, Marijke van der; Weerd, E. Van De; Visser, Gerard H.A.

doi:10.1016/0378-3782(94)90040-x

Cited by 29 publications

(10 citation statements)

References 14 publications

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“…The literature search identified 109 articles examining 9862 fetuses7–9, 11–116. The number of published articles in 5‐year groups demonstrates a normal distribution with a peak of activity in motor research between 1980 and 1990 and a decline thereafter (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Normal fetal motility: an overview

Vries

Fong

2006

Ultrasound in Obstet & Gyne

184

141

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Section: Resultsmentioning

confidence: 99%

Normal fetal motility: an overview

Vries

Fong

2006

Ultrasound in Obstet & Gyne

184

141

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“…Despite some debate as to whether a period of quiet waking in fetuses exists that is comparable to alertness in neonates (Pillai & James, 1990a), the original definitions remain widely used. There is a large literature articulating the development of state parameters around this framework (Arabin & Riedewald, 1992; Arduini et al, 1986; Mulder et al, 1994; Nijhuis et al, 1999; Nijhuis & van de Pas, 1992; Swartjes, van Geijn, Mantel, & van Woerden, 1990; Timor-Tritsch et al, 1978; van de Pas et al, 1994; Visser, Poelmann-Weesjes, Cohen, & Bekedam, 1987), some based solely on motor activity and heart rate and some including eye movement.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, most studies occur during daytime hours when investigators are at work but those findings may not generalize to other times. For example, there is evidence that fetal heart rate patterns consistent with REM sleep occur more often in the afternoon, and that the fetus is more awake and active in the early evening (Mulder et al, 1994). …”

Section: Chapter 13 Fetal Neurobehavioral Research Reimaginedmentioning

confidence: 99%

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DiPietro¹,

Costigan²,

Voegtline³

2015

Monographs Society Res Child

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Among the earliest volumes of this Monograph series was a report by Lester Sontag and colleagues, of the esteemed Fels Institute, on the heart rate of the human fetus as an expression of the developing nervous system. Here, some 75 years later, we commemorate this work and provide historical and contemporary context on knowledge regarding fetal development, as well as results from our own research. These are based on synchronized monitoring of maternal and fetal parameters assessed between 24 and 36 weeks gestation on 740 maternal-fetal pairs compiled from eight separate longitudinal studies, which commenced in the early 1990s. Data include maternal heart rate, respiratory sinus arrhythmia, and electrodermal activity and fetal heart rate, motor activity, and their integration. Hierarchical linear modeling of developmental trajectories reveals that the fetus develops in predictable ways consistent with advancing parasympathetic regulation. Findings also include: within-fetus stability (i.e., preservation of rank ordering over time) for heart rate, motor, and coupling measures; a transitional period of decelerating development near 30 weeks gestation; sex differences in fetal heart rate measures but not in most fetal motor activity measures; modest correspondence in fetal neurodevelopment among siblings as compared to unrelated fetuses; and deviations from normative fetal development in fetuses affected by intrauterine growth restriction and other conditions. Maternal parameters also change during this period of gestation and there is evidence that fetal sex and individual variation in fetal neurobehavior influence maternal physiological processes and the local intrauterine context. Results are discussed within the framework of neuromaturation, the emergence of individual differences, and the bidirectional nature of the maternal-fetal relationship. We pose a number of open questions for future research. Although the human fetus remains just out of reach, new technologies portend an era of accelerated discovery of the earliest period of development.

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“…Reports of periods of quiet wakefulness (3F), even at term, are rare [van Vliet et al, 1985a;van Woerden et al, 1989;Pillai and James, 1990a;Arabin and Riedewald, 1992;Groome et al, 1995], prompting some to question as to whether a state consistent with alertness actually exists in the fetus [Pillai and James, 1990a]. However, circadian effects on fetal state have been noted, and the incidence of 3F has been reported to be higher in the evening than earlier in the day [Mulder et al, 1994].…”

Section: Fetal Behavioral Statementioning

confidence: 97%

Neurobehavioral assessment before birth

DiPietro

2005

Ment. Retard. Dev. Disabil. Res. Rev.

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The complexities of neurobehavioral assessment of the fetus, which can be neither directly viewed nor manipulated, cannot be understated. Impetus to develop methods for measuring fetal neurobehavioral development has been provided by the recognition that individual differences in neurobehavioral functioning do not originate with birth and acceptance of the key contribution of the antenatal period to postnatal life. Research has centered around four aspects of fetal functioning: heart rate, motor activity, behavioral state, and responsivity to stimulation. Longitudinal studies have revealed that the developmental trajectories of these characteristics parallel the developing nervous system, detected a transitional period between 28 and 32 weeks gestation, and established within-fetal stability during the second half of gestation. Despite the promise of fetal stimulation and habituation paradigms as measures of neural functioning, significant safety and ethical concerns exist. Construction of a unified fetal neurobehavioral scale is premature until a sufficient degree of normative data is available and the predictive validity of specific aspects of fetal neurobehavior to child developmental outcomes is better established.

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Patterns of breathing movements in the near-term human fetus: relationship to behavioural states

Cited by 29 publications

References 14 publications

Normal fetal motility: an overview

Normal fetal motility: an overview

Untitled

Neurobehavioral assessment before birth

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