Patterns of Care in High Risk Radical Prostatectomy Patients: The SEER Cohort

The need for, and utilization of prostate-bed radiotherapy after radical prostatectomy for patients with prostate cancer in British Columbia

“…A large population-based series from the Surveillance, Epidemiology and End Results (SEER) registry reported an overall margin positive rate of 21%. 39 The positive margin rate for pT2 patients in our series (of 30 %) exceeded the 20% threshold held by most Ontario urologists. 11 However, the positive margin rates for pathologic T2 patients in British Columbia are generally comparable to the range of regional rates seen in Ontario (16%-42%), 11 although they are higher than those seen in other jurisdictions ( Table 2).…”

“…The perioperative mortality rate in British Columbia is well within the accepted target described by Cancer Care Ontario (CCO) (< 1 %) and those reported in the literature (0-0.5%). 39 There are a few caveats and potential limitations in our analysis. Pre-treatment stage and risk groupings were not available for many of the prostatectomy cases, and this limited our ability to estimate the extent to which higher risk patients received RP.…”

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] In comparison to the recent large SEER series, need for, and use of, post prostatectomy radiotherapy our margin positive rates exceed those reported for SEER (18% for pT2, and 44% for pT3). 39 Unlike the SEER study, which was also population-based, our study detailed patient data on postoperative PSA, which allowed us to distinguish adjuvant and early salvage radiotherapy. The perioperative mortality rate in British Columbia is well within the accepted target described by Cancer Care Ontario (CCO) (< 1 %) and those reported in the literature (0-0.5%).…”

The need for, and utilization of prostate-bed radiotherapy after radical prostatectomy for patients with prostate cancer in British Columbia

“…A large population-based series from the Surveillance, Epidemiology and End Results (SEER) registry reported an overall margin positive rate of 21%. 39 The positive margin rate for pT2 patients in our series (of 30 %) exceeded the 20% threshold held by most Ontario urologists. 11 However, the positive margin rates for pathologic T2 patients in British Columbia are generally comparable to the range of regional rates seen in Ontario (16%-42%), 11 although they are higher than those seen in other jurisdictions ( Table 2).…”

“…RP Positive surgical margins by pathological stage pT2 overall (%) pT2a (%) pT2b (%) pT3 overall (%) pT3a (%) pT3b (%) pT4 (%) need for, and use of, post prostatectomy radiotherapy our margin positive rates exceed those reported for SEER (18% for pT2, and 44% for pT3). 39 Unlike the SEER study, which was also population-based, our study detailed patient data on postoperative PSA, which allowed us to distinguish adjuvant and early salvage radiotherapy. The perioperative mortality rate in British Columbia is well within the accepted target described by Cancer Care Ontario (CCO) (< 1 %) and those reported in the literature (0-0.5%).…”