Patterns of Childhood Trauma and Psychological Distress among Injecting Heroin Users in China

Wang, Zhen; Du, Jing; Sun, Huiling; Wu, Helen; Xiao, Zeping; Zhao, Min

doi:10.1371/journal.pone.0015882

Cited by 23 publications

(19 citation statements)

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“…Because each of these variables was measured at the same time, the findings might reflect a recall bias, i.e., people who feel less stressed may not report as many negative events as those who feel more stressed. However, the observed relationship between childhood adversity and perceived stress was analogous to findings of prior research showing associations between ACEs and psychological distress and/or reactivity to acute laboratory stressors in both healthy adults (Cagampang et al 2011; Edwards et al 2003; Glaser et al 2006; Kendler et al 2004; McFarlane et al 2005; Pierrehumbert et al 2009; Sesar et al 2010; Tyrka et al 2008) and substance abusers (Back et al 2008; Medrano et al 2002; Wang et al 2010). A vast body of findings from preclinical, human laboratory, and clinical observational studies has shown that stress may contribute to the pathogenesis and progression of substance use disorders (Back et al 2010; Breese et al 2011; Erb et al 1996; Karlsgodt et al 2003; Kreek et al 2005; Laudet et al 2004; Lu et al 2003; Sinha.…”

Section: Discussionsupporting

confidence: 83%

“…The ETI “total score” is derived by summing the number of items positively endorsed in each domain, which gives an index of the total extent of abuse. The ETI-SF was adapted from the earlier 62-item self-report version of the measure (ETI-SR) through factor analysis and other correlational methods and has been shown to have similarly acceptable psychometric properties of validity and internal consistency in healthy and clinical populations (Bremner et al 2007; Plaza et al 2011; Tonmyr et al 2011; Wang et al 2010). …”

Section: Methodsmentioning

confidence: 99%

“…Numerous studies have documented associations between childhood adversity and the development of substance use disorders in adults (Carswell et al 2008; Kendler et al 2000; Pilowsky et al 2009; Rothman et al 2008). Although no single pathway can be expected to entirely explain this complex relationship, findings showing that substance abusers with a history of ACEs report greater psychological distress than those without this history suggest that alcohol and/or drugs may be used as a form of self-medication by these groups (Medrano et al 2002; Wang et al 2010). There is also a large body of research showing that perceived stress and current daily hassles are also positively associated with substance use and related problems (Back et al 2008; Cole et al 1990; Corbin et al 2013; Kaplan.…”

Section: Introductionmentioning

confidence: 99%

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History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

et al. 2014

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Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, persons with a history of significant childhood adversity seem to experience greater psychological distress than those without this history. Evidence from rodent studies suggests that early life stress may impair dopamine function in ways that increase risks for drug abuse. However, the degree to which these findings translate to other species remains unclear. This study was conducted to examine associations between childhood adversity and dopamine and subjective responses to amphetamine in humans. Following intake assessment, 28 healthy male and female adults, ages 18–29 years, underwent two consecutive 90-minute positron emission tomography (PET) studies with high specific activity [11C]raclopride. The first scan was preceded by intravenous saline; the second by amphetamine (AMPH 0.3 mg/kg). Consistent with prior literature, findings showed positive associations between childhood trauma and current levels of perceived stress. Moreover, greater number of traumatic events and higher levels of perceived stress were each associated with higher ventral striatal dopamine responses to AMPH. Findings of mediation analyses further showed that a portion of the relationship between childhood trauma and dopamine release may be mediated by perceived stress. Overall, results are consistent with preclinical findings suggesting that early trauma may lead to enhanced sensitivity to psychostimulants and that this mechanism may underlie increased vulnerability for drug abuse.

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Section: Discussionsupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

et al. 2014

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“…While evidence suggests that experiences of childhood trauma are strong predictors of depression and suicide in IDU (Marshall, Galea, Wood, & Kerr, 2013; Walton et al, 2011), childhood trauma has received little attention as a risk factor for non-fatal overdose, despite being reported at a high rate within IDU and at-risk (i.e. substance abusing) populations (Kerr et al, 2009; Marshall et al, 2013; Medrano, Zule, Hatch, & Desmond, 1999; Stoltz et al, 2007; Walton et al, 2011; Wang et al, 2010). For example, in a cohort of drug using youth in Vancouver, Canada, 26.8%, 40.7%, 49.6%, 45.7%, and 35.7% reported having experienced sexual abuse, physical abuse, emotional abuse, physical neglect, and emotional neglect, respectively (Kerr et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Associations between childhood trauma and non-fatal overdose among people who inject drugs

Lake

Hayashi

Milloy

et al. 2015

Addictive Behaviors

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Introduction Although people who inject drugs (IDU) remain at a high risk of accidental overdose, interventions that address overdose remain limited. Accordingly there is a continuing need to identify psychological and social factors that shape overdose risk. Despite being reported frequently among IDU, childhood trauma has received little attention as a potential risk factor for overdose. This study aims to evaluate relationships between non-fatal overdose and five forms of childhood maltreatment among a cohort of IDU in Vancouver, Canada. Methods Data was obtained from two prospective cohorts of IDU between December 2005 and May 2013. Multivariate generalized estimating equations (GEE) were used to explore relationships between five forms of childhood trauma and non-fatal overdose, adjusting for potential confounders. Results During the study period, 1697 IDU, including 552 (32.5%) women, were followed. At baseline, 1136 (67.0%) participants reported at least one form of childhood trauma, while 4–9% reported a non-fatal overdose at each semi-annual follow-up. In multivariate analyses, physical [adjusted odds ratio (AOR): 1.36, 95% confidence interval (CI): 1.08–1.71], sexual (AOR: 1.48, CI: 1.17–1.87), and emotional abuse (AOR: 1.54, CI: 1.22–1.93) and physical neglect (AOR: 1.28, CI: 1.01–1.62) were independently associated with non-fatal overdose (all p < 0.05). Conclusions Childhood trauma was common among participants, and reporting an experience of trauma was positively associated with non-fatal overdose. These findings highlight the need to provide intensive overdose prevention to trauma survivors and to incorporate screening for childhood trauma into health and social programs tailored to IDU.

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“…Cette tendance à prédomi-nance masculine est conforme aux conclusions d'études antérieures, qui démontrent que les garçons sont souvent soumis à plusieurs types de victimisation tels l'agression, l'intimidation et les crimes contre la propriété (Finkelhor et al, 2007a(Finkelhor et al, , 2009Finkelhor et al, 2009a ;Wang et al, 2010). Tel que proposé dans un récent article (Chan et al, 2012), deux mécanismes pourraient expliquer la prédominance masculine.…”

Section: Discussionunclassified

Polyvictimisation et comportements à risque chez des élèves chinois du High School1

Chan¹

2014

crimino

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L’étude vise à évaluer la prévalence et les facteurs associés à la polyvictimisation chez l’enfant, ainsi qu’à fournir une estimation fiable du problème dans le contexte chinois. En utilisant une procédure d’échantillonnage stratifiée à deux niveaux, 18 341 élèves chinois ont été recrutés dans six villes de Chine. Ils ont été invités à remplir un questionnaire autoadministré contenant des questions sur leurs victimisations dans l’enfance, leurs comportements de dépendance et leurs comportements sexuels à l’adolescence. La version chinoise validée du questionnaire sur la victimisation juvénile (JVQ pour l’acronyme anglophone) a été utilisée. Les taux de prévalence obtenus, portant sur l’année précédente, sont de 23,2 % pour tout type de victimisation des enfants et 9,2 % pour la polyvictimisation. Vivre en Chine continentale, être parmi les plus jeunes et avoir des frères et soeurs, sont les facteurs associés à l’augmentation du rapport de cote (« odds ratio ») de polyvictimisation. Certains comportements de dépendance et sexuels des adolescents, incluant les jeux de hasard, le tabagisme, l’alcoolisme, les relations sexuelles précoces, les multiples partenaires sexuels, et la grossesse chez les adolescentes, sont également significativement associés à une probabilité accrue de polyvictimisation. Les résultats de cette étude révèlent de fortes associations entre la victimisation des enfants et les comportements à risque, ce qui souligne la nécessité d’une intervention prioritaire en cas de polyvictimisation.The study aims to investigate the prevalence of and factors associated with child poly-victimization, in order to provide a reliable estimate of the problem in the Chinese context. Using a 2-stage stratified sampling procedure, 18,341 high schools students were recruited from 6 cities in China. Students were asked to complete a self-administered questionnaire containing items about child victimization, addictive behaviors and adolescent sexual behaviors. In particular, the validated Chinese version of Juvenile Victimization Questionnaire (JVQ) was employed in this study. Preceding-year prevalence rates were 23.2 % for any type of child victimization and 9.2 % for poly-victimization. Living in Mainland China, being younger in age, and having siblings were associated with increased odds ratios of poly-victimization. Some adolescent addictive and sexual behaviors, including gambling, smoking, alcohol abuse, early sexual intercourse, multiple sex partners and teenage pregnancy, were also significantly associated with increased likelihood of poly-victimization. The findings of this study provide evidence of strong associations between child victimization and risky behaviors, which warrant prioritized intervention in cases of poly-victimization.Este estudio apunta a evaluar la prevalencia y los factores asociados a la poli-victimización del niño así como también a proporcionar una estimación fiable del problema en el contexto chino. Utilizando un procedimiento de muestreo estratificado en dos niveles, 18.341 alumnos c...

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Patterns of Childhood Trauma and Psychological Distress among Injecting Heroin Users in China

Cited by 23 publications

References 39 publications

History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

Associations between childhood trauma and non-fatal overdose among people who inject drugs

Polyvictimisation et comportements à risque chez des élèves chinois du High School1

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