Patterns of circadian activity rhythms and their relationships with fatigue and anxiety/depression in women treated with breast cancer adjuvant chemotherapy

Berger, Ann M.; Wielgus, Kimberly K.; Hertzog, Melody; Fischer, Pamela J.; Farr, Lynne

doi:10.1007/s00520-009-0636-0

Cited by 121 publications

(118 citation statements)

References 35 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…56.61 In the remaining 11 studies, performed in patients with different types of cancer, using different actigraphy devices and different fatigue scales, the degree of fatigue was found to be associated with circadian disruption, poor sleep, or lower daytime physical activity. 13,14,[49][50][51][52][53][54][55][57][58][59][60] Current data thus support the hypothesis that a disturbance in circadian function, as estimated by a locomotor activity biomarker, is associated with increased fatigue. The heterogeneity of the methodological approaches and reporting procedures used worldwide calls for collaborative efforts, as has been pointed out by other authors.…”

Section: Correlations Between Objective Circadian Disruption and Subjmentioning

confidence: 67%

“…Table 1 summarizes the data for 1129 cancer patients for whom actigraphy data were correlated with data from fatigue questionnaires. 13,14,[49][50][51][52][53][54][55][56][57][58][59][60][61] In 2 out of 13 studies, no significant correlation between actigraphy parameters and fatigue was described. 56.61 In the remaining 11 studies, performed in patients with different types of cancer, using different actigraphy devices and different fatigue scales, the degree of fatigue was found to be associated with circadian disruption, poor sleep, or lower daytime physical activity.…”

Section: Correlations Between Objective Circadian Disruption and Subjmentioning

confidence: 99%

See 1 more Smart Citation

Circadian Disruption, Fatigue, and Anorexia Clustering in Advanced Cancer Patients: Implications for Innovative Therapeutic Approaches

et al. 2009

View full text Add to dashboard Cite

A disruption of the circadian timing system, as identified by monitoring of marker biorhythms, is common in cancer patients. The recording of the rest-activity rhythm with a wrist actigraph has been commonly used. This noninvasive monitoring allows a robust estimation of circadian disruption. The authors have previously found that altered patterns of circadian rest-activity rhythms are significantly and independently associated with the severity of fatigue and anorexia in patients with metastatic colorectal cancer. Elevated proinflammatory cytokines could partly account for this circadian disruption and its associated constitutional symptoms. Here, the authors present and discuss the data supporting the hypothesis that circadian disruption is often associated with fatigue and anorexia, which in turn further alter and dampen circadian synchronization, thus, creating a vicious cycle. This body of evidence paves the path for innovative therapeutic approaches targeting the circadian timing system in an effort to diminish constitutional symptoms induced by cancer and some anticancer treatments.

show abstract

Section: Correlations Between Objective Circadian Disruption and Subjmentioning

confidence: 67%

Section: Correlations Between Objective Circadian Disruption and Subjmentioning

confidence: 99%

Circadian Disruption, Fatigue, and Anorexia Clustering in Advanced Cancer Patients: Implications for Innovative Therapeutic Approaches

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In fact, a growing number of recent studies support that fatigue may co-occur with depression and sleep disturbances as part of a symptom cluster in breast cancer patients [30][31][32][33]. Berger et al examined patterns of circadian rhythms and their relationship with fatigue, anxiety, and depression and concluded that disrupted patterns of circadian rhythms were associated with distressing fatigue and depressive symptoms during chemotherapy [30].…”

Section: Discussionmentioning

confidence: 99%

“…The median time [percentile 25, percentile 75 (P25, P75)] between diagnosis (date of the first histological confirmation) and the baseline evaluation was 25 days (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32).…”

Section: Data Collectionmentioning

confidence: 99%

The impact of breast cancer treatments on sleep quality 1 year after cancer diagnosis

Fontes

Pereira

Costa

et al. 2017

Support Care Cancer

View full text Add to dashboard Cite

Purpose The increasing number of women living longer with potential side effects of breast cancer treatment highlights the need of a comprehensive assessment of its burden. Therefore, we aimed to quantify the relation between different breast cancer treatments and sleep quality 1 year after diagnosis. Methods A cohort of 502 newly diagnosed breast cancer patients was prospectively followed. Sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI), at baseline and at the 1-year follow-up. Odds ratios (OR) were computed to quantify the association between patient characteristics and poor sleep quality (PSQI score >5) at baseline, and relative risks (RR) were computed for the association between treatments and the occurrence of poor sleep quality at 1 year. Results A total of 60.2% of the patients had poor sleep quality before breast cancer treatments, especially those with anxiety [OR = 2.86, 95% confidence interval (95%CI) 1.92 to 4.27] or depression (OR = 5.25, 95%CI 2.01 to 13.67). Radiotherapy increased the risk of poor sleep quality at 1 year (RR = 3.71, 95%CI 1.15 to 11.96, for a cumulative dose >50 Gy) and there was a tendency for a higher risk in those submitted to chemotherapy, although not statistically significant.Conclusions Our study shows that sleep disturbances are frequent before cancer treatment and confirms their cooccurrence with other medical conditions, such as anxiety and depression. Different breast cancer treatments increase the risk of impaired sleep quality, therefore contributing to the global disability associated with cancer treatments.

show abstract

“…2 The ability to achieve sufficient restorative sleep is important in the maintenance of physical and psychological well-being. Telomere length (TL) is increasingly being examined as a biomarker of accumulated cellular damage and human aging.…”

mentioning

confidence: 99%

A Nested Case-Controlled Comparison of Telomere Length and Psychological Functioning in Breast Cancer Survivors with and without Insomnia Symptoms

Garland

Palmer²,

Donelson³

et al. 2014

Rejuvenation Research

View full text Add to dashboard Cite

The ability to achieve sufficient restorative sleep is important in the maintenance of physical and mental health; however, disturbed sleep and insomnia symptoms are a common experience among women with breast cancer. In non-cancer populations, insufficient sleep quantity and quality has been associated with shortened telomere length (TL), a measure of accumulated cellular damage and human aging. This feasibility study compared TL in women previously diagnosed with breast cancer with clinically significant insomnia symptoms (n = 70) to an age-and body mass index (BMI)-matched comparison group (n = 70) of breast cancer survivors. Women with significant insomnia symptoms had higher levels of unemployment compared to women without insomnia. TL was positively skewed and shorter in the insomnia group (Median = 6.000, S = 1.000, standard error [SE] = 0.287) than the control group (Median = 6.195, S = -0.269, SE = 0.287); however, this was not significant ( p = 0.29). Women with insomnia also reported significantly higher levels of depression ( p < 0.001), anxiety ( p < 0.001), and fatigue ( p < 0.001). This study provides the first measure of effect size and variability of TL in women with breast cancer and highlights the need for larger sample sizes to investigate the impact of insomnia and co-morbid symptom distress on cellular aging.

show abstract

Patterns of circadian activity rhythms and their relationships with fatigue and anxiety/depression in women treated with breast cancer adjuvant chemotherapy

Abstract: Disrupted patterns of circadian activity rhythms were prevalent and associated with distressing fatigue and depressive symptoms during chemotherapy and at recovery. The intervention resulted in more robust rhythms.

Cited by 121 publications

References 35 publications

Circadian Disruption, Fatigue, and Anorexia Clustering in Advanced Cancer Patients: Implications for Innovative Therapeutic Approaches

Circadian Disruption, Fatigue, and Anorexia Clustering in Advanced Cancer Patients: Implications for Innovative Therapeutic Approaches

The impact of breast cancer treatments on sleep quality 1 year after cancer diagnosis

A Nested Case-Controlled Comparison of Telomere Length and Psychological Functioning in Breast Cancer Survivors with and without Insomnia Symptoms

Contact Info

Product

Resources

About