Patterns of co-evolution between trypanosomes and their hosts deduced from ribosomal RNA and protein-coding gene phylogenies

Hamilton, Patrick B.; Gibson, Wendy; Stevens, Jamie R.

doi:10.1016/j.ympev.2007.03.023

Cited by 196 publications

(353 citation statements)

References 65 publications

Supporting

Mentioning

226

Contrasting

Unclassified

Order By: Relevance

“…Our observations support a current model for wider trypanosome evolution where ecological host fitting has been proposed to define major parasite clades (Hamilton et al . 2007; Lukes et al . 2014).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

et al. 2015

View full text Add to dashboard Cite

An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes. Trypanosoma cruzi, a genetically heterogeneous, multi‐host zoonosis, provides an ideal system to examine the sylvatic diversification of parasitic protozoa. In Bolivia, T. cruzi I, the oldest and most widespread genetic lineage, is pervasive across a range of ecological clines. High‐resolution nuclear (26 loci) and mitochondrial (10 loci) genotyping of 199 contemporaneous sylvatic TcI clones was undertaken to provide insights into the biogeographical basis of T. cruzi evolution. Three distinct sylvatic parasite transmission cycles were identified: one highland population among terrestrial rodent and triatomine species, composed of genetically homogenous strains (A r = 2.95; PA/L = 0.61; DAS = 0.151), and two highly diverse, parasite assemblages circulating among predominantly arboreal mammals and vectors in the lowlands (A r = 3.40 and 3.93; PA/L = 1.12 and 0.60; DAS = 0.425 and 0.311, respectively). Very limited gene flow between neighbouring terrestrial highland and arboreal lowland areas (distance ~220 km; FST = 0.42 and 0.35) but strong connectivity between ecologically similar but geographically disparate terrestrial highland ecotopes (distance >465 km; FST = 0.016–0.084) strongly supports ecological host fitting as the predominant mechanism of parasite diversification. Dissimilar heterozygosity estimates (excess in highlands, deficit in lowlands) and mitochondrial introgression among lowland strains may indicate fundamental differences in mating strategies between populations. Finally, accelerated parasite dissemination between densely populated, highland areas, compared to uninhabited lowland foci, likely reflects passive, long‐range anthroponotic dispersal. The impact of humans on the risk of epizootic Chagas disease transmission in Bolivia is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

“…2005), while others favour ecological fitting as a more parsimonious explanation for contemporary host associations (Hamilton et al . 2007; Agosta & Klemens 2008; Llewellyn et al . 2009a).…”

Section: Introductionmentioning

confidence: 99%

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

et al. 2015

View full text Add to dashboard Cite

show abstract

“…It is thus plausible that the trypanosome species found in this primitive mammal has been acquired from aquatic leeches carrying fish trypanosomes (Stevens et al, 2001). Thus trypanosomes have not strictly coevolved with their vertebrate hosts; instead, a key factor in the evolutionary radiation of trypanosomes appears to have been transmission between vertebrates in shared environments (Stevens et al, 2001;Hamilton et al, 2007).…”

Section: The Origin Of Trypanosomesmentioning

confidence: 99%

Kinetoplastid phylogenetics, with special reference to the evolution of parasitic trypanosomes

Stevens

2008

Parasite

View full text Add to dashboard Cite

Summary :To fully understand the evolutionary history of parasitic kinetoplastids and to understand the context within which the evolution of each parasite group has developed, an understanding not just of the parasites, but of all kinetoplastids is required. Accordingly, this paper provides an overview of kinetoplastid evolution and systematics, including coverage of the proposal by Moreira et al. (2004) to divide kinetoplasts into Prokinetoplastina (Ichthyobodo and Perkinsiella) and Metakinetoplastina (other bodonids and trypanosomatids). The implications of such a revision, with regard to correctly identifying outgroup taxa for studies of evolution within taxa of medical importance, are addressed, together with a more detailed review of the evolution and origins of the trypanosomes in the light of new phylogenies, new approaches and revisions in kinetoplastid systematics.KEY WORDS : kinetoplastid, trypanosome, Trypanosomatidae, Bodonidae, Prokinetoplastina, Metakinetoplastina, evolution.* School of Biosciences, University of Exeter, Exeter EX4 4PS, UK. E-mail: j.r.stevens@ex.ac.uk 2000) and even in those parasites of medical importance, it is little more than a decade since the widespread introduction of DNA sequencing technologies has allowed the evolution of parasitic trypanosomatids (and kinetoplastids in general) to be evaluated by formal phylogenetic analysis (Fernandes et al., 1993;Alvarez et al., 1996;Maslov et al., 1996;Lukes et al., 1997;Haag et al., 1998;Hannaert et al., 1998;Stevens et al., 1999Stevens et al., , 2001Wright et al., 1999;Hamilton et al., 2004;Moreira et al., 2004). To fully understand the evolutionary history of parasitic kinetoplastids and to understand the context within which the evolution of each parasite group has unfolded, an understanding not just of the parasites, but also of broader kinetoplastid phylogenetics is required. Accordingly, this paper provides an overview of kinetoplastid phylogenetics and evolution, together with a more detailed review of the evolution of the trypanosomes in the light of recent revisions in kinetoplastid systematics. For more comprehensive details of these topics, in addition to the references given above, readers are referred to reviews by Maslov et al. (2001), Stevens et al. (2001) and, most recently, Simpson et al. (2006). KINTEOPLASTID PHYLOGENETICST he order Kinetoplastida comprises a group of protozoa defined by the presence of a characteristic organelle, the kinetoplast (Vickerman, 1976), a large modified mitochondrion. Traditionally, the taxonomy of kinetoplastids has been based on morphological characters and lifecycles, with the group being subdivided into two suborders: Bodonina and Trypanosomatina (Vickerman, 1976; Lom, 1976 (Castellani, 1903;Bruce & Nabarro, 1903;Lyons, 1992), haemoflagellate parasites of humans and domestic animals, including trypanosomes and Leishmania spp. are among some of the most wellstudied agents of parasitic diseases known today. In consequence, some of these organisms have long been the subject of invest...

show abstract

“…Os morfotipos eram determinados pela posição do cinetoplasto e do flagelo, a forma celular, entre outros caracteres. A maioria dos gêneros mostra um subconjunto de diversos morfotipos, porém só um deles é considerado típico, servindo como um critério taxonômico importante para a definição do gênero (Maslov et al, 2013 (Hoare, 1972;Simpson et al, 2006;Hamilton et al, 2007;Stevens, 2008).…”

Section: Família Trypanosomatidaeunclassified

“…A transmissão dos tripanossomas por vetores hematófagos determina que pelo menos uma parte do ciclo de vida ocorra no hospedeiro vertebrado, com a invasão de tecidos (por exemplo, o Sistema Nervoso Central por T. brucei) e células (células musculares por T. cruzi) (Hamilton et al, 2007). O desenvolvimento no hospedeiro invertebrado é complexo e variado, envolvendo frequentemente ciclos de diferenciação e multiplicação no trato digestório, assim como migrações a diferentes locais de desenvolvimento.…”

Section: Família Trypanosomatidaeunclassified

Spliced Leader (SL) RNA: análises de genes e regiões intergênicas com aportes na filogenia, taxonomia e genotipagem de <i>Trypanosoma</i> spp. de todas as classes de vertebrados.

Alvarez¹

View full text Add to dashboard Cite

Patterns of co-evolution between trypanosomes and their hosts deduced from ribosomal RNA and protein-coding gene phylogenies

Cited by 196 publications

References 65 publications

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

Kinetoplastid phylogenetics, with special reference to the evolution of parasitic trypanosomes

Spliced Leader (SL) RNA: análises de genes e regiões intergênicas com aportes na filogenia, taxonomia e genotipagem de <i>Trypanosoma</i> spp. de todas as classes de vertebrados.

Contact Info

Product

Resources

About