Patterns of cognitive change in elderly patients during and 6 months after hospitalisation: A prospective cohort study

Chen, Chia‐Hui; Chiu, Ming‐Jang; Chen, Sui Pi; Cheng, Chia Min; Huang, Guan‐Hua

doi:10.1016/j.ijnurstu.2010.03.011

Cited by 35 publications

(31 citation statements)

References 28 publications

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“…Recently, a population-based study among older adults without cognitive impairment prior to hospitalization reported cognitive reduction after hospitalization associated with baseline comorbidity [24]. Furthermore, hospi- talized patients within the normal range of MMSE who had increased their cognitive function 6 months after hospitalization had lower baseline morbidity than those who had reduced cognitive functioning at T2 [22]. However, none of these studies had explored participants in strata by degree of baseline cognitive function.…”

Section: Discussionmentioning

confidence: 99%

“…Some of the decline and dysfunction may be reversible if due to delirium, and improvement may be reported over the ensuing year after hospitalization [17]. Over the last few years there is, however, a growing amount of literature reporting that cognitive functioning in many elderly patients tends to decline after hospitalization due to specific disorders like stroke [18], heart failure [19], lung disorders [20] and surgery of various kinds [21,22]. There are few studies of the change in cognitive functioning after hospitalization in samples of elderly patients with a wide variety of medical diagnoses and treatments and normal cognitive functioning on admission to hospital [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Decline One Year after Hospitalization in Older Adults without Dementia

Helvik¹,

Selbæk

Engedal

2012

Dement Geriatr Cogn Disord

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Background/Aims: We studied cognitive functioning 1 year after hospitalization (T2) in patients at least 65 years old without cognitive impairment at baseline (T1). Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at both time points. We included 211 (114 women) patients with a mean age of 78.3 (SD 7.0) years and an MMSE score of 24 and above. Results: At T2, 69 (32.7%) patients had an MMSE score below 24. In participants with MMSE 24–26 at T1, cognitive decline was related to impaired physical self-maintenance, a decline in the performance of the instrumental activities of daily living, impaired hearing and less reading ability. In participants with MMSE 27–30, cognitive decline was associated with higher comorbidity (Charlson Index) and impaired physical self-maintenance and hearing. Conclusion: A reduced functioning level and increased comorbidity predicted a decline in cognitive functioning.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cognitive Decline One Year after Hospitalization in Older Adults without Dementia

Helvik¹,

Selbæk

Engedal

2012

Dement Geriatr Cogn Disord

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“…In a sample of 291 medical and surgical patients aged 65 or older without “profound cognitive impairment” at hospital admission based upon a Mini Mental State Examination (MMSE) greater than or equal to 20, 8 cognitive status was assessed at admission and discharge and at 3 and 6 months post-discharge. The investigators distinguished several patterns of cognitive change.…”

Section: Cognitive Impairment After Hospitalizationmentioning

confidence: 99%

“…5 Recent research shows that patients may additionally be at risk for cognitive decline after hospitalization. 6–8 This is a significant public health issue, as those over the age of 65 are the most frequently hospitalized and have the longest length of stay. In the United States alone, the number of adults over 65 is expected to reach 79 million by 2030, making up 19% of the population.…”

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confidence: 99%

Hospitalization and Cognitive Decline: Can the Nature of the Relationship Be Deciphered?

Mathews¹,

Arnold²,

Epperson³

2014

The American Journal of Geriatric Psychiatry

112

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Background Evidence for a relationship between hospitalization and incident cognitive decline exists mainly in the literature focusing on critical care hospitalization. Recent studies, however, have also found an association between noncritical care hospitalization and the development of cognitive decline. Objective This article will review the literature pertaining to hospitalization and cognitive decline, including hospitalizations for both critical and noncritical care, and in medical and surgical patients. The article will also explore the various factors that have been implicated in the development of cognitive decline and dementia. Methods Review of the literature was completed using PubMed and Medline search programs. Results Several articles supporting evidence for the association between hospitalization and cognitive decline are available. Evidence for potential mediating factors also does exist. Conclusions There is evidence to support an association between hospitalization and development of cognitive decline. Factors that could mediate this association include, but may not be limited to, delirium, medications, stress, and depression. There is a need for further research in this area in order to better understand the underlying pathophysiology involved in the development of cognitive decline and dementia and to determine if preventive measures might be beneficial in decreasing risk for cognitive decline for patients who are hospitalized.

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“…In one prospective cohort study (13), elderly people who were admitted to the surgical-medical wards of a hospital showed a high prevalence of cognitive decline during their hospital stay and after discharge. Trajectory analyses showed persistent and accelerated decline of cognitive function in some patient groups (13). These findings suggested that even a common surgical or medical hospitalization, with its concomitant tissue damage or infection, could be detrimental to the cognitive function of elderly people.…”

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confidence: 99%

Systemic Infections May Cause Cognitive Deterioration and Neurodegeneration*

Chiu¹

2014

Critical Care Medicine

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Patterns of cognitive change in elderly patients during and 6 months after hospitalisation: A prospective cohort study

Cited by 35 publications

References 28 publications

Cognitive Decline One Year after Hospitalization in Older Adults without Dementia

Cognitive Decline One Year after Hospitalization in Older Adults without Dementia

Hospitalization and Cognitive Decline: Can the Nature of the Relationship Be Deciphered?

Systemic Infections May Cause Cognitive Deterioration and Neurodegeneration*

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