Pandemic fatigue has threatened the efforts to contain the coronavirus disease 2019 (COVID-19) worldwide; thus, government-mandated preventive measures have declined. The Japanese government has implemented several methods to address COVID-19′s spread, including hand hygiene, mask requirements, and social distancing. This study is the first to examine the socioeconomic factors affecting Japan’s decline in COVID-19 prevention measures. It utilized the Preference Parameters Study of the Osaka University Institute of Social and Economic Research data of the 2021 and 2022 waves. With approximately 1580 observations, we detected a 10%, 4%, and 13% decline in hand hygiene practice, mask-wearing, and social distancing, respectively, between January 2021 and January 2022. Men were more likely to dislike the hand hygiene practice and mask-wearing and were also more reluctant to maintain social distancing. Moreover, financially satisfied individuals were positively associated with a decrease in the hand hygiene practice, while those with greater assets were more likely to dislike maintaining social distancing. People who exercised regularly were less likely to abandon the hand hygiene practices. Our results highlighted the significance of selective prevention programs targeting specific groups to promote compliance and lead to more effective pandemic management and less fatigue or discontentment.