Patterns of dyslipidemia amongst hypertensive patients in Abuja, North Central Nigeria

Onyegbutulem, H C; Dogo, D; Alu, Francis E.; Dankyau, Musa; Olorunfemi, David Samuel; Abdullahi, Faruk; Akerele, Isaac O; Bala, Nafisah Ja ́afar; Ibeabuchi, Ugo Nnenna; Mohammed, Maimuna Onyi

doi:10.11604/pamj.2021.39.11.28807

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…We found that group I had 40 males and 36 females and group II had 38 males and 38 females. Henry et al [12] found that the most frequent dyslipidaemic form was reduced HDL, seen in 96.1% and 94% of new and old respectively; followed by elevated LDL, 86% and 48.2% in new and old respectively. The female gender related significantly, p<0.05, with elevated total cholesterol and elevated LDL in the new group, and reduced HDL in the old group.…”

Section: Discussionmentioning

confidence: 99%

Assessment of patterns of dyslipidaemia amongst hypertensive patients

Khan¹,

Chavan²,

Upreti³

et al. 2022

Int. J. Adv. Community Med.

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Background: Abnormalities in serum lipid and lipoprotein levels (Dyslipidaemia) are recognized as major modifiable cardiovascular disease (CVD) risk factors and have been identified as independent risk factors for essential hypertension giving rise to the term dyslipidemic hypertension. The present study was conducted to assess patterns of dyslipidaemia amongst hypertensive patients. Materials and Methods: 76 hypertensive patients of both genders were recruited. Group I consisted of hypertensive patients and group II had healthy control. Systolic (SBP) and diastolic (DBP) blood pressures, Body mass index (BMI), Fasting blood glucose and fasting serum lipid profile was recorded. Results: Group I had 40 males and 36 females and group II had 38 males and 38 females. In group I and group II, SBP (mm Hg) was 162.4 and 116.4, DBP (mm Hg) was 98.4 and 70.2, BMI (kg/m 2 ) was 28.6 and 26.2, WC (cm) was 96.4 and 90.4, WHR was 0.98 and 0.94, FBS (mmol/L) was 5.1 and 4.6, TG was 1.24 and 1.10, HDL-c was 1.26 and 1.24, LDL-c was 3.01 and 2.42 and TC was 4.82 and 4.15 respectively. Elevated TC (≥5.2 mmol/L) was seen in 34% and 7.5%, elevated TG (≥1.7 mmol/L) in 7% and 1%, elevated LDL-C (≥3.4 mmol/L) in 29% and 6.2%, low HDL-C (<1.04 mmol/L) in 22% and 15%, no lipid abnormality in 46% and 72%, one lipid abnormality in 20% and 16% and >2 lipid abnormality in 24% and 12% in group I and II respectively. Conclusion: There was high patterns of dyslipidemia amongst hypertensive patients as compared to healthy subjects.

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Section: Discussionmentioning

confidence: 99%

Assessment of patterns of dyslipidaemia amongst hypertensive patients

Khan¹,

Chavan²,

Upreti³

et al. 2022

Int. J. Adv. Community Med.

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“…Onyegbutulem, H. C. et al reported the commonest dyslipidaemic type to be reduced High-density lipoprotein, HDL (96.1%), followed by elevated low-density lipoprotein, LDL (78.6%), then, elevated total cholesterol, (62.3%) TCHOL and elevated triglycerides, TG 43.5%. [14] Pokharel, D.R. et al reported most prevalent single lipid disorder was increased non-HDL-C (75.5%) while the least prevalent was hypercholesterolemia (43.7%).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Diabetes and Dyslipidemia Patterns amongst Hypertensive Patients in a Tertiary Cardiac Centre in Kathmandu, Nepal

Roka¹,

Neupane²,

Simkhada³

et al. 2023

WJCD

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Background: Dyslipidemia and hypertension are independent cardiovascular risk factors that are linked by insulin resistance and they require follow-up and more aggressive therapeutic strategies. Hence, the present study was done to study the prevalence of Diabetes and Dyslipidemia patterns in hypertensive patients. Methods: A cross-sectional observational study was done on patients with hypertension for duration of one year, i.e. from Feb 2022 to January 2023. A total of 726 hypertensive Patients were included. All calculations and statistical analyses were processed by SPSS 25.0. Results: A Total of 726 patients with a history of hypertension were included; the average age was 55, with 24.2% of patients belonging to the age group 51 -60; 55.8% were males and 44.2% were females. In the present study, the prevalence of diabetes was 29.06% and 35.5% of patients in the prediabetic stage. The most frequent dyslipidaemic form was reduced HDL, seen in 96.1% and 94% of new and old respectively; followed by elevated LDL, 86% and 48.2% in new and old respectively. It was followed by elevated TG level and Total cholesterol levels. Conclusion: There was a high prevalence of diabetes, pre-diabetes as well as dyslipidemia in hypertensive patients.

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High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

Katundu

Mukhula

Phiri

et al. 2022

BMC Cardiovasc Disord

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Background Dyslipidaemia drives the process of atherosclerosis, and hence a significant modifiable risk factor complicating hypertension and diabetes. In Malawi, the prevalence, screening and management of dyslipidaemia among persons with diabetes mellitus have not been reported. This study aimed to investigate the prevalence, biochemical characteristics, screening and management practices for dyslipidaemia among persons with diabetes mellitus, hypertension, and diabetes mellitus and hypertension comorbidity at Queen Elizabeth Central hospital in Blantyre, Malawi. Methods This was a cross-sectional study conducted in 2021. A total of 256 adult participants (diabetes mellitus = 100); hypertension = 100; both conditions = 56) were included. Medical data and anthropometric measurements were recorded. Blood samples were analysed for HbA1C and serum lipids. Associated risk factors for dyslipidaemia were also assessed. Results Dyslipidaemia was prevalent in 58%, 55%, and 70% of participants with diabetes mellitus, hypertension, and both conditions. Low-density lipoprotein cholesterol (LDL-C) dyslipidaemia was the most common in all participant groups. Participants with both diabetes and hypertension had 2.4 times (95% CI 1.2–4.6) increased risk of LDL-C dyslipidaemia than those with diabetes alone (p < 0.02). Being overweight or obese and age over 30 years were risk factors for dyslipidaemia in participants with diabetes mellitus alone (OR 1.3 (95% CI 1.1–1.6), p < 0.04, and OR 2.2 (95% CI 1.2–4.7) (p < 0.01), respectively. Overweight and obesity predicted LDL-C dyslipidaemia in hypertensive patients (OR 3.5 (95% CI 1.2–9.9) p < 0.001). Poorly controlled hypertension and the use of beta-blockers and thiazide diuretics predicted dyslipidaemia among patients with both diabetes mellitus and hypertension (OR 6.50 CI 1.45–29.19; and OR 5.20 CI 1.16–23.36 respectively). None of the participants had a lipogram performed before the study or were on lipid-lowering therapy. Conclusions Dyslipidaemia with LDL-C derangement was highly prevalent, especially in individuals with both diabetes mellitus and hypertension, and there was absent use of lipid-lowering therapy. Screening and managing dyslipidaemia should be reinforced to reduce the risk of cardiovascular complications in this population at increased risk.

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Patterns of dyslipidemia amongst hypertensive patients in Abuja, North Central Nigeria

Cited by 4 publications

References 34 publications

Assessment of patterns of dyslipidaemia amongst hypertensive patients

Assessment of patterns of dyslipidaemia amongst hypertensive patients

Prevalence of Diabetes and Dyslipidemia Patterns amongst Hypertensive Patients in a Tertiary Cardiac Centre in Kathmandu, Nepal

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

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